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Mfap5 Gene Detail
Summary
  • Symbol
    Mfap5
  • Name
    microfibrillar associated protein 5
  • Synonyms
    MAGP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354387
    NCBI Gene: 50530
  • Gene Overview
    MyGene.info: MFAP5
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:122513383-122529290 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 57.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354387
protein coding gene Chr6:122505845-122529290 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031227
protein coding gene Chr6:125597289-125619950 (+)
A/J MGP_AJ_G0031196
protein coding gene Chr6:120843980-120867146 (+)
AKR/J MGP_AKRJ_G0031125
protein coding gene Chr6:124183295-124207367 (+)
BALB/cJ MGP_BALBcJ_G0031205
protein coding gene Chr6:120527810-120551642 (+)
C3H/HeJ MGP_C3HHeJ_G0030924
protein coding gene Chr6:124130245-124154480 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031664
protein coding gene Chr6:128879881-128902934 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028823
protein coding gene Chr6:117453979-117477095 (+)
CAST/EiJ MGP_CASTEiJ_G0030314
protein coding gene Chr6:124397262-124422728 (+)
CBA/J MGP_CBAJ_G0030888
protein coding gene Chr6:133914075-133940834 (+)
DBA/2J MGP_DBA2J_G0031044
protein coding gene Chr6:119757683-119782607 (+)
FVB/NJ MGP_FVBNJ_G0030996
protein coding gene Chr6:118706289-118730736 (+)
LP/J MGP_LPJ_G0031124
protein coding gene Chr6:125749279-125771992 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031031
protein coding gene Chr6:137888447-137912816 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031694
protein coding gene Chr6:124076029-124099767 (+)
PWK/PhJ MGP_PWKPhJ_G0030028
protein coding gene Chr6:118593004-118616291 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029855
protein coding gene Chr6:122204999-122228546 (+)
WSB/EiJ MGP_WSBEiJ_G0030396
protein coding gene Chr6:124382067-124406132 (+)



Homology
more
  • Human Ortholog
    MFAP5, microfibril associated protein 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MFAP5, microfibril associated protein 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAT9, MAGP2, MAGP-2, MFAP-5, MP25
  • Links
    NCBI Gene ID: 8076
    neXtProt AC: NX_Q13361
    UniProt: Q13361

  • Chr Location
    12p13.31; chr12:8645943-8662888 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased circulating neutrophils.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 50530 NCBI Gene Model | MGI Sequence Detail 15908 C57BL/6J ±  kb
transcript NM_015776 RefSeq | MGI Sequence Detail 1505 C57BL/6  
polypeptide Q9QZJ6 UniProt | EBI | MGI Sequence Detail 164 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 52
    cDNA 52

    Microarray probesets 6
References
more
  • Summaries
    All 36
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:60689 Frankfater C, et al., Organization of the mouse microfibril-associated glycoprotein-2 (MAGP-2) gene. Mamm Genome. 2000 Mar;11(3):191-5
  • Latest
    J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory