Lats2
Gene Detail

Symbol Name ID

Lats2 large tumor suppressor 2 MGI:1354386

Feature Type

protein coding gene

Genetic Map

Chromosome 14

30.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr14:57642077-57758388 bp, - strand From VEGA annotation of GRCm38   116312 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Lats2 ± 2 cM)

Protein SuperFamily: serine/threonine protein kinase LATS
Gene Tree: Lats2

Human ortholog

LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) NCBI Gene ID 26524
Human Synonyms: KPM
Human Chr13:21547175-21635722 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(7) : Targeted(5) Gene trapped(2)
 

Homozygous null mice display embryonic lethality with decreased cell proliferation, chromosomal instability, atrial hyperplasia, ventricular hypoplasia, delayed embryonic development, an irregular kinked neural tube, and hemorrhages.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	cell cycle, cell division, ...
Component	cytoplasm, cytoskeleton, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (167)    Tissues (108)    Images (101)
Theiler Stages: 11, 13, 28

Assay Type	Results
RNA in situ	2
In situ reporter (knock in)	127
RT-PCR	38

cDNA source data(72)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(73) cDNA(72) Primer pair(1)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000037614 (Evidence)
Ensembl Gene Model	ENSMUSG00000021959 (Evidence)
Entrez Gene	50523 (Evidence)
UniGene	347899
DFCI	TC1574031, TC1592620, TC1627466, TC1670321
DoTS	DT.110748342, DT.110748382, DT.110748388, DT.529103, DT.91374478, DT.94268663, DT.94387707, DT.94410456, DT.97386210
EC	2.7.11.1
PDB	2COS
Consensus CDS Project	CCDS27158.1, CCDS49508.1
International Mouse Knockout Project Status	Lats2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037614	VEGA Gene Model | MGI Sequence Detail	116312	C57BL/6J
transcript	OTTMUST00000097026	VEGA | MGI Sequence Detail	5191	Not Applicable
polypeptide	OTTMUSP00000054318	VEGA | MGI Sequence Detail	1042	Not Applicable

All sequences(102) RefSeq(4) UniProt(9)

Polymorphisms

RFLP(1) : SNPs(151 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR017892	Protein kinase, C-terminal
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
InterPro	IPR009060	UBA-like
InterPro	IPR015940	Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
Protein Ontology	PR:000009687	serine/threonine-protein kinase LATS2

References

(Earliest) J:60693 Yabuta N, et al., Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Genomics. 2000 Jan 15;63(2):263-70
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(43)

Other accession IDs

MGI:2145781, MGI:2145807, MGI:2443802