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Lats2
Gene Detail
Symbol

Name
ID
Lats2
large tumor suppressor 2
MGI:1354386
Feature Type
protein coding gene
Genetic Map
Chromosome 14
30.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:57642077-57758388 bp, - strand
From VEGA annotation of GRCm38

  116312 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56678  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: serine/threonine protein kinase LATS
Gene Tree: Lats2

Human
homologs
Human Homolog LATS2, large tumor suppressor kinase 2
NCBI Gene ID 26524
neXtProt AC  NX_Q9NRM7
Human Synonyms  KPM
Human Chr (Location)  13q11-q12; chr13:20973036-21061583 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality with decreased cell proliferation, chromosomal instability, atrial hyperplasia, ventricular hypoplasia, delayed embryonic development, an irregular kinked neural tube, and hemorrhages.
 
Phenotype Images(2)
Interactions
Lats2 interacts with 393 markers (Mir1a-2, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (167)    Tissues (108)    Images (101)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
In situ reporter (knock in) 127
RT-PCR 38
cDNA source data(71)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(72) cDNA(71) Primer pair(1)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000037614 (Evidence)
Ensembl Gene ModelENSMUSG00000021959 (Evidence)
Entrez Gene50523 (Evidence)
UniGene347899
DFCITC1574031, TC1592620, TC1627466, TC1670321
DoTSDT.110748342, DT.110748382, DT.110748388, DT.529103, DT.91374478, DT.94268663, DT.94387707, DT.94410456, DT.97386210
EC2.7.11.1
PDB2COS
Consensus CDS ProjectCCDS27158.1, CCDS49508.1
International Mouse Knockout Project StatusLats2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037614 VEGA Gene Model | MGI Sequence Detail 116312 C57BL/6J ±  kb
transcript OTTMUST00000097026 VEGA | MGI Sequence Detail 5191 Not Applicable 
polypeptide OTTMUSP00000054318 VEGA | MGI Sequence Detail 1042 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(10) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(273 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR009060 UBA-like
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
Protein Ontology PR:000009687 serine/threonine-protein kinase LATS2
References
(Earliest) J:60693 Yabuta N, et al., Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Genomics. 2000 Jan 15;63(2):263-70
(Latest) J:206812 Shao D, et al., A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat Commun. 2014 Feb 14;5:3315
All references(50)
Other
accession IDs
MGI:2145781, MGI:2145807, MGI:2443802

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory