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Lats2
Gene Detail
Symbol

Name
ID
Lats2
large tumor suppressor 2
MGI:1354386
Feature Type
protein coding gene
Genetic Map
Chromosome 14
30.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:57642077-57758388 bp, - strand
From VEGA annotation of GRCm38

  116312 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56678  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LATS2
Protein SuperFamily: serine/threonine protein kinase LATS
Gene Tree: Lats2

Human
homologs
LATS2, large tumor suppressor kinase 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 26524
neXtProt AC: NX_Q9NRM7

Human Synonyms: KPM

Human Chr (Location): 13q12.11; chr13:20973036-21061583 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display embryonic lethality with decreased cell proliferation, chromosomal instability, atrial hyperplasia, ventricular hypoplasia, delayed embryonic development, an irregular kinked neural tube, and hemorrhages.
 
Phenotype Images(2)
Interactions
Lats2 interacts with 392 markers (Mir1a-2, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (167)    Tissues (107)    Images (101)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
In situ reporter (knock in) 127
RT-PCR 38
cDNA source data(71)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lats2 ; ZFIN lats2    NEW 
Molecular
reagents
All nucleic(72) cDNA(71) Primer pair(1)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000037614 (Evidence)
Ensembl Gene Model ENSMUSG00000021959 (Evidence)
Entrez Gene 50523 (Evidence)
UniGene 347899
DFCI TC1574031, TC1592620, TC1627466, TC1670321
DoTS DT.110748342, DT.110748382, DT.110748388, DT.529103, DT.91374478, DT.94268663, DT.94387707, DT.94410456, DT.97386210
EC 2.7.11.1
PDB 2COS
Consensus CDS Project CCDS27158.1, CCDS49508.1
International Mouse Phenotyping Consortium Status Lats2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037614 VEGA Gene Model | MGI Sequence Detail 116312 C57BL/6J ±  kb
transcript OTTMUST00000097026 VEGA | MGI Sequence Detail 5191 Not Applicable 
polypeptide OTTMUSP00000054318 VEGA | MGI Sequence Detail 1042 Not Applicable 

For the selected sequences
All sequences(110) RefSeq(10) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(273 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR028742 Serine/threonine-protein kinase LATS2
InterPro IPR009060 UBA-like
InterPro IPR015940 Ubiquitin-associated domain
Protein Ontology PR:000009687 serine/threonine-protein kinase LATS2
References
(Earliest) J:60693 Yabuta N, et al., Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Genomics. 2000 Jan 15;63(2):263-70
(Latest) J:223215 Chen Q, et al., Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP. Genes Dev. 2015 Jun 15;29(12):1285-97
All references(50)
Other
accession IDs
MGI:2145781, MGI:2145807, MGI:2443802

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory