About   Help   FAQ
Gpr31b Gene Detail
Summary
  • Symbol
    Gpr31b
  • Name
    G protein-coupled receptor 31, D17Leh66b region
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354372
    NCBI Gene: 436440
  • Member of
    Gpr31 cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr17:13270208-13271167 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354372
 protein coding gene Chr17:13269901-13271183 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0023127
 protein coding gene Chr17:10682721-10683457 (-)
C3H/HeJ MGP_C3HHeJ_G0022889
 protein coding gene Chr17:10938247-10939193 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0021071
 protein coding gene Chr17:9048374-9049390 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0022862
 protein coding gene Chr17:11874506-11875452 (-)
DBA/2J MGP_DBA2J_G0022963
 protein coding gene Chr17:4652319-4653345 (-)
FVB/NJ MGP_FVBNJ_G0022930
 protein coding gene Chr17:4431290-4435556 (-)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0023596
 protein coding gene Chr17:10691547-10692323 (-)
PWK/PhJ MGP_PWKPhJ_G0022114
 protein coding gene Chr17:4198357-4199683 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021946
 protein coding gene Chr17:4483392-4493414 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GPR31, G protein-coupled receptor 31
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR31, G protein-coupled receptor 31
  • Synonyms
    12-HETER, HETER, HETER1
  • Links
    NCBI Gene ID: 2853
    neXtProt AC: NX_O00270
    UniProt: O00270

  • Chr Location
    6q27; chr6:167155247-167157980 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a reduced response to enteric bacteria, showing defective dendrite protrusions of CX3CR1+ cells in the small intestine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 436440 NCBI Gene Model | MGI Sequence Detail 960 C57BL/6J ±  kb
transcript NM_001013832 RefSeq | MGI Sequence Detail 960 Not Specified  
polypeptide F8VQN3 UniProt | EBI | MGI Sequence Detail 319 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1
References
more
  • Summaries
    All 17
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:57788 Schimenti JC, ORFless, intronless, and mutant transcription units in the mouse t complex responder (Tcr) locus. Mamm Genome. 1999 Oct;10(10):969-76
  • Latest
    J:345511 Liu Q, et al., Pyruvate enhances oral tolerance via GPR31. Int Immunol. 2022 Jul 4;34(7):343-352
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory