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Prok2 Gene Detail
Summary
  • Symbol
    Prok2
  • Name
    prokineticin 2
  • Synonyms
    Bombina variegata 8kDa protein, Bv8, PK2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354178
    NCBI Gene: 50501
Location & Maps
more
  • Sequence Map
    Chr6:99711299-99726392 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15094 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 46.29 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PROK2, prokineticin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PROK2, prokineticin 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BV8, HH4, KAL4, MIT1, PK2
  • Links
    NCBI Gene ID: 60675
    neXtProt AC: NX_Q9HC23

  • Chr Location
    3p13; chr3:71771655-71785206 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9268
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PROK2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PROK2 associations

Human Disease Mouse Models
       Hypogonadotropic Hypogonadism 4 with or without Anosmia; HH4   OMIM: 610628
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Prok2
Mice homozygous for a knock-out allele have a significantly reduced olfactory bulb displaying abnormal architecture and accumulation of neuronal progenitors in the rostral migratory stream.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057660 VEGA Gene Model | MGI Sequence Detail 15094 C57BL/6J ±  kb
transcript OTTMUST00000141689 VEGA | MGI Sequence Detail 1423 Not Applicable  
polypeptide OTTMUSP00000073998 VEGA | MGI Sequence Detail 128 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    81 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
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  • All nucleic 8
    cDNA 6
    Primer pair 2

    Microarray probesets 4
References
more
  • Summaries
    All 42
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:58759 Wechselberger C, et al., The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes. FEBS Lett. 1999 Nov 26;462(1-2):177-81
  • Latest
    J:215112 Xiao L, et al., Signaling role of prokineticin 2 on the estrous cycle of female mice. PLoS One. 2014;9(3):e90860

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory