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Prok2
Gene Detail
Symbol

Name
ID
Prok2
prokineticin 2
MGI:1354178
Synonyms
Bombina variegata 8kDa protein, Bv8, PK2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
46.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:99711299-99726392 bp, - strand
From NCBI annotation of GRCm38

  15094 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9268  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PROK2
Gene Tree: Prok2

Human
homologs
PROK2, prokineticin 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 60675
neXtProt AC: NX_Q9HC23

Human Synonyms: BV8, HH4, KAL4, MIT1, PK2

Human Chr (Location): 3p13; chr3:71771655-71785206 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PROK2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Spontaneous(1) Targeted(4)
Genomic Mutations involving Prok2 (1)
 
Mice homozygous for a knock-out allele have a significantly reduced olfactory bulb displaying abnormal architecture and accumulation of neuronal progenitors in the rostral migratory stream.
 
Interactions
Prok2 interacts with 122 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process activation of MAPK activity, angiogenesis, ...
Component extracellular region
Function G-protein coupled receptor binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (11)    Tissues (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 11
cDNA source data(6)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase prok2 ; ZFIN prok2    NEW 
Molecular
reagents
All nucleic(8) cDNA(6) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000030069 (Evidence)
Entrez Gene 50501 (Evidence)
UniGene 87365
DFCI TC1587148, TC1592436
DoTS DT.50315195, DT.87036015, DT.91335737, DT.97382366
NIA Mouse Gene Index U027683
Consensus CDS Project CCDS20388.1, CCDS20389.1, CCDS51864.1
International Mouse Phenotyping Consortium Status Prok2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 50501 NCBI Gene Model | MGI Sequence Detail 15094 C57BL/6J ±  kb
transcript NM_015768 RefSeq | MGI Sequence Detail 1513 C57BL/6 
polypeptide Q9QXU7 UniProt | EBI | MGI Sequence Detail 128 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(81 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009523 Prokineticin
InterPro IPR023569 Prokineticin domain
Protein Ontology PR:000013265 prokineticin-2
Graphical View of Protein Domain Structure
References
(Earliest) J:58759 Wechselberger C, et al., The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes. FEBS Lett. 1999 Nov 26;462(1-2):177-81
(Latest) J:215112 Xiao L, et al., Signaling role of prokineticin 2 on the estrous cycle of female mice. PLoS One. 2014;9(3):e90860
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory