Prok2
Gene Detail

Symbol Name ID

Prok2 prokineticin 2 MGI:1354178

Synonyms

Bombina variegata 8kDa protein, Bv8, PK2

Feature Type

protein coding gene

Genetic Map

Chromosome 6

46.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:99711299-99726392 bp, - strand From NCBI annotation of GRCm38   15094 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9268  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Prok2

Human homologs

Human Homolog		PROK2, prokineticin 2
NCBI Gene ID		60675
neXtProt AC		NX_Q9HC23
Human Synonyms		BV8, HH4, KAL4, MIT1, PK2
Human Chr (Location)		3p13; chr3:71820806-71834357 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PROK2

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele have a significantly reduced olfactory bulb displaying abnormal architecture and accumulation of neuronal progenitors in the rostral migratory stream.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	angiogenesis, cell proliferation, ...
Component	extracellular region
Function	G-protein coupled receptor binding

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (11)    Tissues (11)   
Theiler Stages: 10, 18, 23, 28

Assay Type	Results
RT-PCR	11

cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(6) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000030069 (Evidence)
Entrez Gene	50501 (Evidence)
UniGene	87365
DFCI	TC1587148, TC1592436
DoTS	DT.50315195, DT.87036015, DT.91335737, DT.97382366
NIA Mouse Gene Index	U027683
Consensus CDS Project	CCDS20388.1, CCDS20389.1, CCDS51864.1
International Mouse Knockout Project Status	Prok2

Sequences

Length	Strain/Species
genomic	50501	NCBI Gene Model | MGI Sequence Detail	15094	C57BL/6J
transcript	NM_015768	RefSeq | MGI Sequence Detail	1513	C57BL/6
polypeptide	Q9QXU7	UniProt | EBI | MGI Sequence Detail	128	Not Applicable

All sequences(35) RefSeq(6) UniProt(3)

Polymorphisms

PCR(1) : SNPs(80 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009523	Prokineticin
InterPro	IPR023569	Prokineticin domain
Protein Ontology	PR:000013265	prokineticin-2

Graphical View of Protein Domain Structure

References

(Earliest) J:58759 Wechselberger C, et al., The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes. FEBS Lett. 1999 Nov 26;462(1-2):177-81
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(40)