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Prok2
Gene Detail
 Symbol
Name
ID
Prok2
prokineticin 2
MGI:1354178
Synonyms Bombina variegata 8kDa protein, Bv8, PK2
Feature Type protein coding gene
Genetic Map
Chromosome 6
46.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:99711299-99726392 bp, - strand
From NCBI annotation of GRCm38

  15094 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9268  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Prok2

Human
homologs
Human Homolog PROK2, prokineticin 2
NCBI Gene ID 60675
neXtProt AC  NX_Q9HC23
Human Synonyms  BV8, HH4, KAL4, MIT1, PK2
Human Chr (Location)  3p13; chr3:71771655-71785206 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PROK2
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
 
Mice homozygous for a knock-out allele have a significantly reduced olfactory bulb displaying abnormal architecture and accumulation of neuronal progenitors in the rostral migratory stream.
 
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process angiogenesis, cell proliferation, ...
Component extracellular region
Function G-protein coupled receptor binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (11)    Tissues (11)   
Theiler Stages: 10, 18, 23, 28
Assay TypeResults
RT-PCR 11
cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(8) cDNA(6) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000030069 (Evidence)
Entrez Gene50501 (Evidence)
UniGene87365
DFCITC1587148, TC1592436
DoTSDT.50315195, DT.87036015, DT.91335737, DT.97382366
NIA Mouse Gene IndexU027683
Consensus CDS ProjectCCDS20388.1, CCDS20389.1, CCDS51864.1
International Mouse Knockout Project StatusProk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 50501 NCBI Gene Model | MGI Sequence Detail 15094 C57BL/6J ±  kb
transcript NM_015768 RefSeq | MGI Sequence Detail 1513 C57BL/6 
polypeptide Q9QXU7 UniProt | EBI | MGI Sequence Detail 128 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(81 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009523 Prokineticin
InterPro IPR023569 Prokineticin domain
Protein Ontology PR:000013265 prokineticin-2
Graphical View of Protein Domain Structure
References (Earliest) J:58759 Wechselberger C, et al., The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes. FEBS Lett. 1999 Nov 26;462(1-2):177-81
(Latest) J:198587 Xin H, et al., G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells. J Biol Chem. 2013 May 10;288(19):13842-9
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory