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Txnrd1 Gene Detail
Summary
  • Symbol
    Txnrd1
  • Name
    thioredoxin reductase 1
  • Synonyms
    TR, TR1, TR alpha, TrxR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354175
    NCBI Gene: 50493
  • Gene Overview
    MyGene.info: TXNRD1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:82833951-82897712 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63762 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 40.66 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TXNRD1, thioredoxin reductase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TXNRD1, thioredoxin reductase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GRIM-12, TR, TR1, TRXR1, TXNR
  • Links
    NCBI Gene ID: 7296
    neXtProt AC: NX_Q16881
    UniProt: Q16881

  • Chr Location
    12q23.3; chr12:104215779-104350307 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 4 alleles in 5 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit early embryonic lethality (by E10.5) and display severe growth retardation and fail to turn. Embryos also exhibit decreased cell proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020250 Ensembl Gene Model | MGI Sequence Detail 63762 C57BL/6J ±  kb
    transcript ENSMUST00000219368 Ensembl | MGI Sequence Detail 3622 Not Applicable  
    polypeptide ENSMUSP00000151629 Ensembl | MGI Sequence Detail 613 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      560 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016871 thioredoxin reductase 1, cytoplasmic
    • EC
    • InterPro Domains
      IPR016156 FAD/NAD-linked reductase, dimerisation domain superfamily
      IPR023753 FAD/NAD(P)-binding domain
      IPR036188 FAD/NAD(P)-binding domain superfamily
      IPR001100 Pyridine nucleotide-disulphide oxidoreductase, class I
      IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site
      IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
      IPR006338 Thioredoxin/glutathione reductase selenoprotein
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 16
      Primer pair 3

      Microarray probesets 5
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 27
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:254576 Prigge JR, et al., Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase. Cell Rep. 2017 Jun 27;19(13):2771-2781

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory