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Ebi3
Gene Detail
Symbol

Name
ID
Ebi3
Epstein-Barr virus induced gene 3
MGI:1354171
Synonyms
EBI-3, IL-27
Feature Type
protein coding gene
Genetic Map
Chromosome 17
29.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:55952623-55957021 bp, + strand
From Ensembl annotation of GRCm38

  4399 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4207  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EBI3
Gene Tree: Ebi3

Human
homologs
EBI3, Epstein-Barr virus induced 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10148
neXtProt AC: NX_Q14213

Human Synonyms: IL27B, IL-27B

Human Chr (Location): 19p13.3; chr19:4229302-4237542 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(6) Targeted(2)
 
Mice homozygous for a knock-out allele exhibit significantly reduced numbers of invariant natural killer (NK) T cells, show impaired Th2 responses, are resistant to the induction of oxazolone-induced colitis, and display impaired early Th1 immunity against Leishmania parasitic infections.
 
Interactions
Ebi3 interacts with 24 markers (Mir16-1, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cytokine-mediated signaling pathway
Component extracellular region, extracellular space, ...
Function cytokine activity, cytokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (178)    Tissues (26)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 162
RT-PCR 16
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN ebi3    NEW 
Molecular
reagents
All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000003206 (Evidence)
Entrez Gene 50498 (Evidence)
UniGene 256798
DFCI TC1579478
DoTS DT.490077
NIA Mouse Gene Index U018119
Consensus CDS Project CCDS28888.1
International Mouse Phenotyping Consortium Status Ebi3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003206 Ensembl Gene Model | MGI Sequence Detail 4399 C57BL/6J ±  kb
transcript ENSMUST00000003274 Ensembl | MGI Sequence Detail 1170 Not Applicable 
polypeptide ENSMUSP00000003274 Ensembl | MGI Sequence Detail 228 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015373 Interferon alpha/beta receptor, beta chain
InterPro IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved site
Protein Ontology PR:000001386 interleukin-27 subunit beta
References
(Earliest) J:64475 Puttagunta R, et al., Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. Genome Res. 2000 Sep;10(9):1369-80
(Latest) J:213242 Wang RX, et al., Interleukin-35 induces regulatory B cells that suppress autoimmune disease. Nat Med. 2014 Jun;20(6):633-41
All references(61)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory