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Ebi3
Gene Detail
Symbol

Name
ID
Ebi3
Epstein-Barr virus induced gene 3
MGI:1354171
Synonyms
EBI-3, IL-27
Feature Type
protein coding gene
Genetic Map
Chromosome 17
29.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:55952623-55957021 bp, + strand
From Ensembl annotation of GRCm38

  4399 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4207  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Ebi3

Human
homologs
Human Homolog EBI3, Epstein-Barr virus induced 3
NCBI Gene ID 10148
neXtProt AC  NX_Q14213
Human Synonyms  IL27B, IL-27B
Human Chr (Location)  19p13.3; chr19:4229318-4237546 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(6) Targeted(2)
 
Mice homozygous for a knock-out allele exhibit significantly reduced numbers of invariant natural killer (NK) T cells, show impaired Th2 responses, are resistant to the induction of oxazolone-induced colitis, and display impaired early Th1 immunity against Leishmania parasitic infections.
 
Interactions
Ebi3 interacts with 24 markers (Mir16-1, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cytokine-mediated signaling pathway
Component extracellular region, extracellular space, ...
Function cytokine activity, cytokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (178)    Tissues (26)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 162
RT-PCR 16
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000003206 (Evidence)
Entrez Gene50498 (Evidence)
UniGene256798
DFCITC1579478
DoTSDT.490077
NIA Mouse Gene IndexU018119
Consensus CDS ProjectCCDS28888.1
International Mouse Knockout Project StatusEbi3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003206 Ensembl Gene Model | MGI Sequence Detail 4399 C57BL/6J ±  kb
transcript ENSMUST00000003274 Ensembl | MGI Sequence Detail 1170 Not Applicable 
polypeptide ENSMUSP00000003274 Ensembl | MGI Sequence Detail 228 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015373 Interferon alpha/beta receptor, beta chain
InterPro IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved site
Protein Ontology PR:000001386 interleukin-27 subunit beta
References
(Earliest) J:64475 Puttagunta R, et al., Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. Genome Res. 2000 Sep;10(9):1369-80
(Latest) J:213242 Wang RX, et al., Interleukin-35 induces regulatory B cells that suppress autoimmune disease. Nat Med. 2014 Jun;20(6):633-41
All references(61)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory