Ebi3
Gene Detail

Symbol Name ID

Ebi3 Epstein-Barr virus induced gene 3 MGI:1354171

Synonyms

EBI-3, IL-27

Feature Type

protein coding gene

Genetic Map

Chromosome 17

29.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:55952623-55957021 bp, + strand From Ensembl annotation of GRCm38   4399 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4207  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Ebi3

Human homologs

Human Homolog		EBI3, Epstein-Barr virus induced 3
NCBI Gene ID		10148
neXtProt AC		NX_Q14213
Human Synonyms		IL27B, IL-27B
Human Chr (Location)		19p13.3; chr19:4229540-4237525 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(2) Gene trapped(6)
 

Mice homozygous for a knock-out allele exhibit significantly reduced numbers of invariant natural killer (NK) T cells, show impaired Th2 responses, are resistant to the induction of oxazolone-induced colitis, and display impaired early Th1 immunity against Leishmania parasitic infections.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	cytokine-mediated signaling pathway
Component	extracellular region, extracellular space, ...
Function	cytokine activity, cytokine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (178)    Tissues (26)    Images (23)
Theiler Stages: 6, 8, 23, 28

Assay Type	Results
RNA in situ	162
RT-PCR	16

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000003206 (Evidence)
Entrez Gene	50498 (Evidence)
UniGene	256798
DFCI	TC1579478
DoTS	DT.490077
NIA Mouse Gene Index	U018119
Consensus CDS Project	CCDS28888.1
International Mouse Knockout Project Status	Ebi3

Sequences

Length	Strain/Species
genomic	ENSMUSG00000003206	Ensembl Gene Model | MGI Sequence Detail	4399	C57BL/6J
transcript	ENSMUST00000003274	Ensembl | MGI Sequence Detail	1170	Not Applicable
polypeptide	ENSMUSP00000003274	Ensembl | MGI Sequence Detail	228	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(29 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR015373	Interferon alpha/beta receptor, beta chain
InterPro	IPR003530	Long hematopoietin receptor, soluble alpha chain, conserved site
Protein Ontology	PR:000001386	interleukin-27 subunit beta

References

(Earliest) J:64475 Puttagunta R, et al., Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. Genome Res. 2000 Sep;10(9):1369-80
(Latest) J:193049 Liu Z, et al., IL-27 enhances the survival of tumor antigen-specific CD8(+) T cells and programs them into IL-10-producing, memory precursor-like effector cells. Eur J Immunol. 2013 Feb;43(2):468-79
All references(56)