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Ttpa Gene Detail
Summary
  • Symbol
    Ttpa
  • Name
    tocopherol (alpha) transfer protein
  • Synonyms
    alpha TTP, alpha-TTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354168
    NCBI Gene: 50500
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:20007938-20030785 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22848 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 7.76 cM, cytoband A3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TTPA, alpha tocopherol transfer protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TTPA, alpha tocopherol transfer protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    alphaTTP, ATTP, AVED, TTP1
  • Links
    NCBI Gene ID: 7274
    neXtProt AC: NX_P49638
    UniProt: P49638

  • Chr Location
    8q12.3; chr8:63058409-63086523 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ttpa mouse models; 1 with human TTPA associations

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    4 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit vitamin E deficiency. Placentas from pregnant females have reduced labyrinthine trophoblasts resulting in midgestational embryonic lethality. Homozygotes for one targeted null allele display late-onset ataxia and retinal degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000006384 VEGA Gene Model | MGI Sequence Detail 22848 C57BL/6J ±  kb
    transcript OTTMUST00000014515 VEGA | MGI Sequence Detail 3123 Not Applicable  
    polypeptide OTTMUSP00000020367 VEGA | MGI Sequence Detail 262 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      101 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 1
      cDNA 38
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:58384 Terasawa Y, et al., Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development. J Lipid Res. 1999 Nov;40(11):1967-77
    • Latest
      J:208020 Ulatowski L, et al., Vitamin E is essential for Purkinje neuron integrity. Neuroscience. 2014 Feb 28;260:120-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory