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Ttpa Gene Detail
Summary
  • Symbol
    Ttpa
  • Name
    tocopherol (alpha) transfer protein
  • Synonyms
    alpha TTP, alpha-TTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354168
    NCBI Gene: 50500
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:20007938-20030785 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 7.76 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354168
protein coding gene Chr4:20007909-20030822 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028086
protein coding gene Chr4:17011849-17038885 (+)
A/J MGP_AJ_G0028044
protein coding gene Chr4:16561751-16585620 (+)
AKR/J MGP_AKRJ_G0028009
protein coding gene Chr4:16925373-16949475 (+)
BALB/cJ MGP_BALBcJ_G0028055
protein coding gene Chr4:16539935-16562870 (+)
C3H/HeJ MGP_C3HHeJ_G0027785
protein coding gene Chr4:17034040-17055130 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028498
protein coding gene Chr4:17714887-17738668 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025840
protein coding gene Chr4:15336730-15360449 (+)
CAST/EiJ MGP_CASTEiJ_G0027240
protein coding gene Chr4:16853819-16879972 (+)
CBA/J MGP_CBAJ_G0027758
protein coding gene Chr4:18224774-18250866 (+)
DBA/2J MGP_DBA2J_G0027901
protein coding gene Chr4:16377314-16402600 (+)
FVB/NJ MGP_FVBNJ_G0027867
protein coding gene Chr4:16105472-16126008 (+)
LP/J MGP_LPJ_G0028010
protein coding gene Chr4:17071966-17094957 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027900
protein coding gene Chr4:19282509-19305724 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028557
protein coding gene Chr4:16817869-16848026 (+)
PWK/PhJ MGP_PWKPhJ_G0026960
protein coding gene Chr4:16276948-16305337 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026789
protein coding gene Chr4:16694491-16719846 (+)
WSB/EiJ MGP_WSBEiJ_G0027317
protein coding gene Chr4:16860063-16881815 (+)



Homology
more
  • Human Ortholog
    TTPA, alpha tocopherol transfer protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TTPA, alpha tocopherol transfer protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    alphaTTP, ATTP, AVED, TTP1
  • Links
    NCBI Gene ID: 7274
    neXtProt AC: NX_P49638
    UniProt: P49638

  • Chr Location
    8q12.3; chr8:63058409-63086523 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ttpa mouse models; 1 with human TTPA associations

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    4 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit vitamin E deficiency. Placentas from pregnant females have reduced labyrinthine trophoblasts resulting in midgestational embryonic lethality. Homozygotes for one targeted null allele display late-onset ataxia and retinal degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000073988 Ensembl Gene Model | MGI Sequence Detail 22848 C57BL/6J ±  kb
    transcript ENSMUST00000098244 Ensembl | MGI Sequence Detail 3053 Not Applicable  
    polypeptide ENSMUSP00000095845 Ensembl | MGI Sequence Detail 278 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 2
      cDNA 38
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 9
      Phenotypes 24
    • Earliest
      J:58384 Terasawa Y, et al., Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development. J Lipid Res. 1999 Nov;40(11):1967-77
    • Latest
      J:243822 Yui D, et al., Enhanced Phospholipase A2 Group 3 Expression by Oxidative Stress Decreases the Insulin-Degrading Enzyme. PLoS One. 2015;10(12):e0143518

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory