Ttpa
Gene Detail

Symbol Name ID

Ttpa tocopherol (alpha) transfer protein MGI:1354168

Synonyms

alpha TTP, alpha-TTP

Feature Type

protein coding gene

Genetic Map

Chromosome 4

7.76 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:20007938-20030785 bp, + strand From VEGA annotation of GRCm38   22848 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37295  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cellular retinaldehyde-binding protein
Gene Tree: Ttpa

Human homologs

Human Homolog		TTPA, tocopherol (alpha) transfer protein
NCBI Gene ID		7274
neXtProt AC		NX_P49638
Human Synonyms		alphaTTP, ATTP, AVED, TTP1
Human Chr (Location)		8q12.3; chr8:63972047-63998612 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TTPA

Alleles and phenotypes

All alleles(15) : Targeted(4) Gene trapped(11)
 

Homozygotes for targeted null mutations exhibit vitamin E deficiency. Placentas from pregnant females have reduced labyrinthine trophoblasts resulting in midgestational embryonic lethality. Homozygotes for one targeted null allele display late-onset ataxia and retinal degeneration.

 
Human Diseases Modeled Using Mouse Ttpa (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	embryonic placenta development, negative regulation of establishment of blood-brain barrier, ...
Component	cytoplasm, cytosol, ...
Function	transporter activity, vitamin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (107)    Tissues (21)    Images (8)
Theiler Stages: 11, 13, 17, 21, 23, 26, 28

Assay Type	Results
Northern blot	47
Western blot	9
RT-PCR	16
RNase protection	35

cDNA source data(37)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(41) Genomic(1) cDNA(38) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006384 (Evidence)
Ensembl Gene Model	ENSMUSG00000073988 (Evidence)
Entrez Gene	50500 (Evidence)
UniGene	24375
DFCI	TC1581268, TC1594504
DoTS	DT.101261713, DT.91355190
NIA Mouse Gene Index	U004114
Consensus CDS Project	CCDS17995.1
International Mouse Knockout Project Status	Ttpa

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006384	VEGA Gene Model | MGI Sequence Detail	22848	C57BL/6J
transcript	OTTMUST00000014515	VEGA | MGI Sequence Detail	3123	Not Applicable
polypeptide	OTTMUSP00000020367	VEGA | MGI Sequence Detail	262	Not Applicable

All sequences(42) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(59 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001071	Cellular retinaldehyde binding/alpha-tocopherol transport
InterPro	IPR001251	CRAL-TRIO domain
InterPro	IPR011074	CRAL/TRIO, N-terminal domain
Protein Ontology	PR:000016799	alpha-tocopherol transfer protein

References

(Earliest) J:58384 Terasawa Y, et al., Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development. J Lipid Res. 1999 Nov;40(11):1967-77
(Latest) J:183401 Fujita K, et al., Vitamin E decreases bone mass by stimulating osteoclast fusion. Nat Med. 2012 Apr;18(4):589-94
All references(52)