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Ttpa
Gene Detail
Symbol

Name
ID
Ttpa
tocopherol (alpha) transfer protein
MGI:1354168
Synonyms
alpha TTP, alpha-TTP
Feature Type
protein coding gene
Genetic Map
Chromosome 4
7.76 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:20007938-20030785 bp, + strand
From VEGA annotation of GRCm38

  22848 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37295  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: TTPA
Protein SuperFamily: cellular retinaldehyde-binding protein
Gene Tree: Ttpa

Human
homologs
TTPA, tocopherol (alpha) transfer protein
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7274
neXtProt AC: NX_P49638

Human Synonyms: alphaTTP, ATTP, AVED, TTP1

Human Chr (Location): 8q12.3; chr8:63059488-63086100 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TTPA

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit vitamin E deficiency. Placentas from pregnant females have reduced labyrinthine trophoblasts resulting in midgestational embryonic lethality. Homozygotes for one targeted null allele display late-onset ataxia and retinal degeneration.
 
Human Diseases Modeled in Mice Using Ttpa (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(4)
Interactions
Ttpa interacts with 280 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process embryonic placenta development, intermembrane transport, ...
Component cytoplasm, cytosol, ...
Function lipid binding, phosphatidylinositol-3,4-bisphosphate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (105)    Tissues (20)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 47
Western blot 9
RT-PCR 15
RNase protection 34
cDNA source data(37)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ttpa ; ZFIN ttpa    NEW 
Molecular
reagents
All nucleic(41) Genomic(1) cDNA(38) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006384 (Evidence)
Ensembl Gene Model ENSMUSG00000073988 (Evidence)
Entrez Gene 50500 (Evidence)
UniGene 24375
DFCI TC1594504, TC1581268
DoTS DT.101261713, DT.91355190
NIA Mouse Gene Index U004114
PDB 3W68, 3W67
Consensus CDS Project CCDS17995.1
International Mouse Phenotyping Consortium Status Ttpa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006384 VEGA Gene Model | MGI Sequence Detail 22848 C57BL/6J ±  kb
transcript OTTMUST00000014515 VEGA | MGI Sequence Detail 3123 Not Applicable 
polypeptide OTTMUSP00000020367 VEGA | MGI Sequence Detail 262 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001071 Cellular retinaldehyde binding/alpha-tocopherol transport
InterPro IPR001251 CRAL-TRIO domain
InterPro IPR011074 CRAL/TRIO, N-terminal domain
Protein Ontology PR:000016799 alpha-tocopherol transfer protein
References
(Earliest) J:58384 Terasawa Y, et al., Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development. J Lipid Res. 1999 Nov;40(11):1967-77
(Latest) J:208020 Ulatowski L, et al., Vitamin E is essential for Purkinje neuron integrity. Neuroscience. 2014 Feb 28;260:120-9
All references(52)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory