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Ttpa
Gene Detail
Symbol

Name
ID
Ttpa
tocopherol (alpha) transfer protein
MGI:1354168
Synonyms
alpha TTP, alpha-TTP
Feature Type
protein coding gene
Genetic Map
Chromosome 4
7.76 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:20007938-20030785 bp, + strand
From VEGA annotation of GRCm38

  22848 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37295  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cellular retinaldehyde-binding protein
Gene Tree: Ttpa

Human
homologs
Human Homolog TTPA, tocopherol (alpha) transfer protein
NCBI Gene ID 7274
neXtProt AC  NX_P49638
Human Synonyms  alphaTTP, ATTP, AVED, TTP1
Human Chr (Location)  8q12.3; chr8:63059488-63086098 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TTPA
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit vitamin E deficiency. Placentas from pregnant females have reduced labyrinthine trophoblasts resulting in midgestational embryonic lethality. Homozygotes for one targeted null allele display late-onset ataxia and retinal degeneration.
 
Human Diseases Modeled Using Mouse Ttpa (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(4)
Interactions
Ttpa interacts with 280 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process embryonic placenta development, intermembrane transport, ...
Component cytoplasm, cytosol, ...
Function lipid binding, phosphatidylinositol-3,4-bisphosphate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (105)    Tissues (20)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 47
Western blot 9
RT-PCR 15
RNase protection 34
cDNA source data(37)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) Genomic(1) cDNA(38) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006384 (Evidence)
Ensembl Gene ModelENSMUSG00000073988 (Evidence)
Entrez Gene50500 (Evidence)
UniGene24375
DFCITC1581268, TC1594504
DoTSDT.91355190, DT.101261713
NIA Mouse Gene IndexU004114
PDB3W68, 3W67
Consensus CDS ProjectCCDS17995.1
International Mouse Knockout Project StatusTtpa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006384 VEGA Gene Model | MGI Sequence Detail 22848 C57BL/6J ±  kb
transcript OTTMUST00000014515 VEGA | MGI Sequence Detail 3123 Not Applicable 
polypeptide OTTMUSP00000020367 VEGA | MGI Sequence Detail 262 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(13)
Polymorphisms
SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001071 Cellular retinaldehyde binding/alpha-tocopherol transport
InterPro IPR001251 CRAL-TRIO domain
InterPro IPR011074 CRAL/TRIO, N-terminal domain
Protein Ontology PR:000016799 alpha-tocopherol transfer protein
References
(Earliest) J:58384 Terasawa Y, et al., Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development. J Lipid Res. 1999 Nov;40(11):1967-77
(Latest) J:208020 Ulatowski L, et al., Vitamin E is essential for Purkinje neuron integrity. Neuroscience. 2014 Feb 28;260:120-9
All references(54)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory