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Sirt6 Gene Detail
Summary
  • Symbol
    Sirt6
  • Name
    sirtuin 6
  • Synonyms
    2810449N18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354161
    NCBI Gene: 50721
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:81457621-81463631 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354161
 protein coding gene Chr10:81457619-81463631 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017569
 protein coding gene Chr10:82359552-82365554 (-)
A/J MGP_AJ_G0017547
 protein coding gene Chr10:79428609-79434386 (-)
AKR/J MGP_AKRJ_G0017508
 protein coding gene Chr10:81607100-81612866 (-)
BALB/cJ MGP_BALBcJ_G0017509
 protein coding gene Chr10:79657096-79663257 (-)
C3H/HeJ MGP_C3HHeJ_G0017332
 protein coding gene Chr10:81715167-81720936 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017963
 protein coding gene Chr10:85177628-85183638 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015652
 protein coding gene Chr10:75624208-75629866 (-)
CAST/EiJ MGP_CASTEiJ_G0016899
 protein coding gene Chr10:81965834-81971845 (-)
CBA/J MGP_CBAJ_G0017304
 protein coding gene Chr10:88528703-88534476 (-)
DBA/2J MGP_DBA2J_G0017410
 protein coding gene Chr10:78632786-78638561 (-)
FVB/NJ MGP_FVBNJ_G0017404
 protein coding gene Chr10:77903622-77911147 (-)
LP/J MGP_LPJ_G0017481
 protein coding gene Chr10:82811872-82817881 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017430
 protein coding gene Chr10:90344463-90350474 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018004
 protein coding gene Chr10:81625617-81631621 (-)
PWK/PhJ MGP_PWKPhJ_G0016680
 protein coding gene Chr10:78544033-78550012 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016470
 protein coding gene Chr10:80574677-80580359 (-)
WSB/EiJ MGP_WSBEiJ_G0016959
 protein coding gene Chr10:81675269-81681279 (-)



Homology
more
  • Human Ortholog
    SIRT6, sirtuin 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIRT6, sirtuin 6
  • Synonyms
    hSIRT6, SIR2L6
  • Links
    NCBI Gene ID: 51548
    neXtProt AC: NX_Q8N6T7
    UniProt: Q8N6T7

  • Chr Location
    19p13.3; chr19:4174109-4182566 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sirt6 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 5 alleles in 6 genetic backgrounds
    7 phenotypes from multigenic genotypes
    2 images
    108 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display late postnatal lethality with lordokyphosis, progressive lymphopenia, loss of subcutaneous fat, reduced bone density, decreased serum glucose, increased chromosomal instability, and increased sensitivity to ionizing radiation. Some KO alleles cause retinal and corneal degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    143
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    147
  • cDNA Data
    10
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50721 NCBI Gene Model | MGI Sequence Detail 6011 C57BL/6J ±  kb
    transcript NM_001378945 RefSeq | MGI Sequence Detail 1756 ZRU/MplStud  
    polypeptide P59941 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 11
      Primer pair 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1920019, MGI:2143519
    References
    more
    • Summaries
      All 189
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 31
      Phenotypes 108
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:346094 Li L, et al., Sirt6 ablation in the liver causes fatty liver that increases cancer risky by upregulating Serpina12. EMBO Rep. 2024 Mar;25(3):1361-1386
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory