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Sirt6 Gene Detail
Summary
  • Symbol
    Sirt6
  • Name
    sirtuin 6
  • Synonyms
    2810449N18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354161
    NCBI Gene: 50721
  • Gene Overview
    MyGene.info: SIRT6
Location & Maps
more
  • Sequence Map
    Chr10:81621785-81627797 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6013 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SIRT6, sirtuin 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SIRT6, sirtuin 6
    Orthology source: HomoloGene
  • Synonyms
    SIR2L6
  • Links
    NCBI Gene ID: 51548
    neXtProt AC: NX_Q8N6T7

  • Chr Location
    19p13.3; chr19:4174109-4182599 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 6924
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SIRT6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 5 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    2 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Chemically induced (other)
    1
  • Gene trapped
    16
  • Targeted
    8
  • Transgenic
    1
  • Genomic Mutations
    1 involving Sirt6
  • Incidental Mutations
Mice homozygous for a null allele display late postnatal lethality with lordokyphosis, progressive lymphopenia, loss of subcutaneous fat, reduced bone density, decreased serum glucose, increased chromosomal instability, and increased sensitivity to ionizing radiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030471 VEGA Gene Model | MGI Sequence Detail 6013 C57BL/6J ±  kb
transcript OTTMUST00000075440 VEGA | MGI Sequence Detail 1891 Not Applicable  
polypeptide OTTMUSP00000039548 VEGA | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    35 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014892 NAD-dependent protein deacetylase sirtuin-6
  • EC
  • InterPro Domains
    IPR029035 DHS-like NAD/FAD-binding domain
    IPR003000 Sirtuin family
    IPR026590 Sirtuin family, catalytic core domain
Molecular
Reagents
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  • All nucleic 12
    cDNA 10
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
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MGI:1920019, MGI:2143519
References
more
  • Summaries
    All 67
    Developmental Gene Expression 5
    Gene Ontology 11
    Phenotypes 32
  • Earliest
    J:64475 Puttagunta R, et al., Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. Genome Res. 2000 Sep;10(9):1369-80
  • Latest
    J:232368 Xiong X, et al., Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells. Diabetologia. 2016 Jan;59(1):151-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory