About   Help   FAQ
Usp21 Gene Detail
Summary
  • Symbol
    Usp21
  • Name
    ubiquitin specific peptidase 21
  • Synonyms
    ESTM28, Usp16, Usp23, W53272
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353665
    NCBI Gene: 30941
Location & Maps
more
  • Sequence Map
    Chr1:171281945-171287991 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6047 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.30 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    USP21, ubiquitin specific peptidase 21
  • Vertebrate Orthologs
    9
  • Human Ortholog
    USP21, ubiquitin specific peptidase 21
    Orthology source: HomoloGene
  • Synonyms
    USP16, USP23
  • Links
    NCBI Gene ID: 27005
    neXtProt AC: NX_Q9UK80

  • Chr Location
    1q22; chr1:161159464-161165726 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    2
  • Gene trapped
    4
  • Targeted
    5
  • Genomic Mutations
    2 involving Usp21
  • Incidental Mutations
Mice homozygous for a null allele are viable and fertile but develop splenomegaly, show an increased percentage of macrophages and neutrophils in spleen, and are more resistant to vesicular stomatitis virus (VSV) infection with elevated interferon production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021702 VEGA Gene Model | MGI Sequence Detail 6047 C57BL/6J ±  kb
transcript OTTMUST00000051489 VEGA | MGI Sequence Detail 2185 Not Applicable  
polypeptide OTTMUSP00000024248 VEGA | MGI Sequence Detail 569 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    73 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • EC
  • InterPro Domains
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease domain
Molecular
Reagents
less
  • All nucleic 78
    Genomic 2
    cDNA 75
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1334424
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
  • Latest
    J:220984 Pannu J, et al., Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation. PLoS One. 2015;10(2):e0117304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory