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Usp21 Gene Detail
Summary
  • Symbol
    Usp21
  • Name
    ubiquitin specific peptidase 21
  • Synonyms
    ESTM28, Usp16, Usp23, W53272
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353665
    NCBI Gene: 30941
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:171281945-171287991 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6047 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.30 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    USP21, ubiquitin specific peptidase 21
  • Vertebrate Orthologs
    9
  • Human Ortholog
    USP21, ubiquitin specific peptidase 21
    Orthology source: HomoloGene, HGNC
  • Synonyms
    USP16, USP23
  • Links
    NCBI Gene ID: 27005
    neXtProt AC: NX_Q9UK80
    UniProt: Q9UK80

  • Chr Location
    1q23.3; chr1:161159458-161165726 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable and fertile but develop splenomegaly, show an increased percentage of macrophages and neutrophils in spleen, and are more resistant to vesicular stomatitis virus (VSV) infection with elevated interferon production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021702 VEGA Gene Model | MGI Sequence Detail 6047 C57BL/6J ±  kb
    transcript OTTMUST00000051489 VEGA | MGI Sequence Detail 2185 Not Applicable  
    polypeptide OTTMUSP00000024248 VEGA | MGI Sequence Detail 569 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      73 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
    • InterPro Domains
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease domain
    Molecular
    Reagents
    less
    • All nucleic 78
      Genomic 2
      cDNA 75
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1334424
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
    • Latest
      J:241585 Chen Y, et al., p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation. J Exp Med. 2017 Apr 03;214(4):991-1010

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory