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Lcmt2 Gene Detail
Summary
  • Symbol
    Lcmt2
  • Name
    leucine carboxyl methyltransferase 2
  • Synonyms
    Tyw4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353659
    NCBI Gene: 329504
  • Gene Overview
    MyGene.info: LCMT2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:121137292-121140698 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 60.37 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353659
protein coding gene Chr2:121128307-121140698 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026381
protein coding gene Chr2:124012253-124024442 (-)
A/J MGP_AJ_G0026342
protein coding gene Chr2:118937399-118949665 (-)
AKR/J MGP_AKRJ_G0026321
protein coding gene Chr2:122280026-122293451 (-)
BALB/cJ MGP_BALBcJ_G0026355
protein coding gene Chr2:119173514-119187204 (-)
C3H/HeJ MGP_C3HHeJ_G0026101
protein coding gene Chr2:122758872-122772210 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026802
protein coding gene Chr2:128074908-128087083 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024182
protein coding gene Chr2:113981280-113994501 (-)
CAST/EiJ MGP_CASTEiJ_G0025563
protein coding gene Chr2:123078545-123091896 (-)
CBA/J MGP_CBAJ_G0026077
protein coding gene Chr2:132538118-132557275 (-)
DBA/2J MGP_DBA2J_G0026216
protein coding gene Chr2:118338433-118350726 (-)
FVB/NJ MGP_FVBNJ_G0026178
protein coding gene Chr2:117157073-117169814 (-)
LP/J MGP_LPJ_G0026317
protein coding gene Chr2:124269514-124282113 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026197
protein coding gene Chr2:136835137-136847245 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026857
protein coding gene Chr2:122393658-122407918 (-)
PWK/PhJ MGP_PWKPhJ_G0025299
protein coding gene Chr2:117940756-117953273 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025098
protein coding gene Chr2:121612211-121625221 (-)
WSB/EiJ MGP_WSBEiJ_G0025632
protein coding gene Chr2:123222798-123235983 (-)



Homology
more
  • Human Ortholog
    LCMT2, leucine carboxyl methyltransferase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LCMT2, leucine carboxyl methyltransferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PPM2, TYW4
  • Links
    NCBI Gene ID: 9836
    neXtProt AC: NX_O60294
    UniProt: O60294

  • Chr Location
    15q15.3; chr15:43327776-43330622 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 329504 NCBI Gene Model | MGI Sequence Detail 3407 C57BL/6J ±  kb
transcript NM_177846 RefSeq | MGI Sequence Detail 3407 C57BL/6  
polypeptide Q8BYR1 UniProt | EBI | MGI Sequence Detail 686 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 32

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory