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Fgd3
Gene Detail
Symbol

Name
ID
Fgd3
FYVE, RhoGEF and PH domain containing 3
MGI:1353657
Synonyms
5830461L01Rik, ZFYVE5
Feature Type
protein coding gene
Genetic Map
Chromosome 13
25.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:49261554-49320311 bp, - strand
From VEGA annotation of GRCm38

  58758 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22925  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: FYVE, RhoGEF and PH domain containing protein(1-4)
Gene Tree: Fgd3

Human
homologs
Human Homolog FGD3, FYVE, RhoGEF and PH domain containing 3
NCBI Gene ID 89846
neXtProt AC  NX_Q5JSP0
Human Synonyms  ZFYVE5
Human Chr (Location)  9q22; chr9:92947319-93036236 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Fgd3 interacts with 227 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process filopodium assembly, regulation of Rho protein signal transduction
Component cytoplasm, cytoskeleton
Function guanyl-nucleotide exchange factor activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (53)    Tissues (18)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
Northern blot 12
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000020966 (Evidence)
Ensembl Gene ModelENSMUSG00000037946 (Evidence)
Entrez Gene30938 (Evidence)
DFCITC1724685, TC1703084, TC1590329
DoTSDT.97347135, DT.94233496, DT.94233494, DT.91336548
NIA Mouse Gene IndexU034760
Consensus CDS ProjectCCDS26499.1
International Mouse Knockout Project StatusFgd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020966 VEGA Gene Model | MGI Sequence Detail 58758 C57BL/6J ±  kb
transcript OTTMUST00000049566 VEGA | MGI Sequence Detail 4698 Not Applicable 
polypeptide OTTMUSP00000022987 VEGA | MGI Sequence Detail 733 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(8) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(153 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR017455 Zinc finger, FYVE-related
InterPro IPR000306 Zinc finger, FYVE-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000007475 FYVE, RhoGEF and PH domain-containing protein 3
References
(Earliest) J:60236 Pasteris NG, et al., Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue. Gene. 2000 Jan 25;242(1-2):237-47
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(33)
Other
accession IDs
MGI:1923341

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory