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Usp25 Gene Detail
Summary
  • Symbol
    Usp25
  • Name
    ubiquitin specific peptidase 25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353655
    NCBI Gene: 30940
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:77013706-77116780 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 44.40 cM, cytoband C3.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    474 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353655
protein coding gene Chr16:77013683-77116783 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022957
protein coding gene Chr16:77119010-77227067 (+)
A/J MGP_AJ_G0022925
protein coding gene Chr16:73719001-73824492 (+)
AKR/J MGP_AKRJ_G0022895
protein coding gene Chr16:75939906-76046265 (+)
BALB/cJ MGP_BALBcJ_G0022927
protein coding gene Chr16:74097100-74201117 (+)
C3H/HeJ MGP_C3HHeJ_G0022689
protein coding gene Chr16:76399446-76505013 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023375
protein coding gene Chr16:79595798-79708844 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020878
protein coding gene Chr16:72192616-72300870 (+)
CAST/EiJ MGP_CASTEiJ_G0022212
protein coding gene Chr16:76771462-76904289 (+)
CBA/J MGP_CBAJ_G0022659
protein coding gene Chr16:83005814-83126918 (+)
DBA/2J MGP_DBA2J_G0022792
protein coding gene Chr16:73552307-73659629 (+)
FVB/NJ MGP_FVBNJ_G0022767
protein coding gene Chr16:72918225-73025368 (+)
LP/J MGP_LPJ_G0022862
protein coding gene Chr16:76872858-76985347 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022786
protein coding gene Chr16:86086497-86208813 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023393
protein coding gene Chr16:76272275-76377165 (+)
PWK/PhJ MGP_PWKPhJ_G0021954
protein coding gene Chr16:73746975-73877862 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021784
protein coding gene Chr16:75872390-76007341 (+)
WSB/EiJ MGP_WSBEiJ_G0022259
protein coding gene Chr16:76467777-76575861 (+)



Homology
more
  • Human Ortholog
    USP25, ubiquitin specific peptidase 25
  • Vertebrate Orthologs
    10
  • Human Ortholog
    USP25, ubiquitin specific peptidase 25
    Orthology source: HomoloGene, HGNC
  • Synonyms
    USP21
  • Links
    NCBI Gene ID: 29761
    neXtProt AC: NX_Q9UHP3
    UniProt: Q9UHP3

  • Chr Location
    21q21.1; chr21:15729947-15880072 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8374
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: USP25
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit increased severity of IL17-induced pulmonary inflammation and MOG-induced experimental autoimmune encephalomyelitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022867 Ensembl Gene Model | MGI Sequence Detail 103075 C57BL/6J ±  kb
    transcript ENSMUST00000023580 Ensembl | MGI Sequence Detail 4776 Not Applicable  
    polypeptide ENSMUSP00000023580 Ensembl | MGI Sequence Detail 1055 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 2
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:60249 Valero R, et al., USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2. Genomics. 1999 Dec 15;62(3):395-405
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory