About   Help   FAQ
Usp25 Gene Detail
Summary
  • Symbol
    Usp25
  • Name
    ubiquitin specific peptidase 25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353655
    NCBI Gene: 30940
Location & Maps
more
  • Sequence Map
    Chr16:77014069-77116779 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      102711 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    USP25, ubiquitin specific peptidase 25
  • Vertebrate Orthologs
    10
  • Human Ortholog
    USP25, ubiquitin specific peptidase 25
    Orthology source: HomoloGene
  • Synonyms
    USP21
  • Links
    NCBI Gene ID: 29761
    neXtProt AC: NX_Q9UHP3

  • Chr Location
    21q11.2; chr21:15729947-15880072 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8374
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: USP25
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Gene trapped
    6
  • Targeted
    9
  • Genomic Mutations
    3 involving Usp25
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit increased severity of IL17-induced pulmonary inflammation and MOG-induced experimental autoimmune encephalomyelitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022867 Ensembl Gene Model | MGI Sequence Detail 102711 C57BL/6J ±  kb
transcript ENSMUST00000023580 Ensembl | MGI Sequence Detail 4412 Not Applicable  
polypeptide ENSMUSP00000023580 Ensembl | MGI Sequence Detail 1055 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    475 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 15
    Primer pair 2

    Microarray probesets 5
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:60249 Valero R, et al., USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2. Genomics. 1999 Dec 15;62(3):395-405
  • Latest
    J:226812 Lin D, et al., Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11324-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory