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Usp25
Gene Detail
Symbol

Name
ID
Usp25
ubiquitin specific peptidase 25
MGI:1353655
Feature Type
protein coding gene
Genetic Map
Chromosome 16
44.40 cM, cytoband C3.1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:77014069-77116779 bp, + strand
From Ensembl annotation of GRCm38

  102711 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8374  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Usp25

Human
homologs
Human Homolog USP25, ubiquitin specific peptidase 25
NCBI Gene ID 29761
neXtProt AC  NX_Q9UHP3
Human Synonyms  USP21
Human Chr (Location)  21q11.2; chr21:15730008-15880072 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(6) Targeted(8)
Genomic Mutations involving Usp25 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit increased severity of IL17-induced pulmonary inflammation and MOG-induced experimental autoimmune encephalomyelitis.
 
Interactions
Usp25 interacts with 289 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (218)    Tissues (72)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 200
RT-PCR 18
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022867 (Evidence)
Entrez Gene30940 (Evidence)
DFCITC1600907, TC1777861, TC1576055
DoTSDT.94246280, DT.94177663, DT.489437
NIA Mouse Gene IndexU017295
EC3.4.19.12
PDB1VDL
Consensus CDS ProjectCCDS28275.1
International Mouse Knockout Project StatusUsp25
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022867 Ensembl Gene Model | MGI Sequence Detail 102711 C57BL/6J ±  kb
transcript ENSMUST00000023580 Ensembl | MGI Sequence Detail 4412 Not Applicable 
polypeptide ENSMUSP00000023580 Ensembl | MGI Sequence Detail 1055 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(8) UniProt(9)
Polymorphisms
SNPs within 2kb(475 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
InterPro IPR009060 UBA-like
InterPro IPR003903 Ubiquitin interacting motif
Protein Ontology PR:000017163 ubiquitin carboxyl-terminal hydrolase 25
References
(Earliest) J:60249 Valero R, et al., USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2. Genomics. 1999 Dec 15;62(3):395-405
(Latest) J:188557 Zhong B, et al., Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. Nat Immunol. 2012 Nov;13(11):1110-7
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory