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Usp25 Gene Detail
Summary
  • Symbol
    Usp25
  • Name
    ubiquitin specific peptidase 25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353655
    NCBI Gene: 30940
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:77014069-77116779 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      102711 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 44.40 cM, cytoband C3.1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    USP25, ubiquitin specific peptidase 25
  • Vertebrate Orthologs
    10
  • Human Ortholog
    USP25, ubiquitin specific peptidase 25
    Orthology source: HomoloGene, HGNC
  • Synonyms
    USP21
  • Links
    NCBI Gene ID: 29761
    neXtProt AC: NX_Q9UHP3
    UniProt: Q9UHP3

  • Chr Location
    21q21.1; chr21:15729947-15880072 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8374
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: USP25
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit increased severity of IL17-induced pulmonary inflammation and MOG-induced experimental autoimmune encephalomyelitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022867 Ensembl Gene Model | MGI Sequence Detail 102711 C57BL/6J ±  kb
    transcript ENSMUST00000023580 Ensembl | MGI Sequence Detail 4412 Not Applicable  
    polypeptide ENSMUSP00000023580 Ensembl | MGI Sequence Detail 1055 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      474 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 5
      Phenotypes 17
    • Earliest
      J:60249 Valero R, et al., USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2. Genomics. 1999 Dec 15;62(3):395-405
    • Latest
      J:242664 Gupta M, et al., Mouse models of Down syndrome: gene content and consequences. Mamm Genome. 2016 Dec;27(11-12):538-555

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/05/2018
    MGI 6.12
    The Jackson Laboratory