Homozygous disruption of this gene leads to early embryonic loss as blastocysts fail to enter the S phase. MEFs heterozygous for a gene trap allele have reduced proliferative capacity while MEFs heterozygous for a null allele show reduced doubling rates, increased apoptosis and premature senescence.
|Ensembl Gene Model||ENSMUSG00000042354 (Evidence)|
|Entrez Gene||30877 (Evidence)|
|DFCI||TC1614198, TC1574586, TC1612641, TC1596694, TC1715900|
|DoTS||DT.101242927, DT.94377892, DT.94262224, DT.493779|
|NIA Mouse Gene Index||U035363|
|Consensus CDS Project||CCDS26905.1|
|International Mouse Knockout Project Status||Gnl3|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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