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Gnl3
Gene Detail
Symbol

Name
ID
Gnl3
guanine nucleotide binding protein-like 3 (nucleolar)
MGI:1353651
Synonyms
NS, nucleostemin
Feature Type
protein coding gene
Genetic Map
Chromosome 14
19.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:31012434-31019089 bp, - strand
From Ensembl annotation of GRCm38

  6656 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56670  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GNL3
Gene Tree: Gnl3

Human
homologs
GNL3, guanine nucleotide binding protein-like 3 (nucleolar)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 26354
neXtProt AC: NX_Q9BVP2

Human Synonyms: C77032, E2IG3, NNP47, NS

Human Chr (Location): 3p21.1; chr3:52685920-52694497 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(187) : Gene trapped(183) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous disruption of this gene leads to early embryonic loss as blastocysts fail to enter the S phase. MEFs heterozygous for a gene trap allele have reduced proliferative capacity while MEFs heterozygous for a null allele show reduced doubling rates, increased apoptosis and premature senescence.
 
Phenotype Images(2)
Interactions
Gnl3 interacts with 64 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell proliferation, positive regulation of pri-miRNA transcription from RNA polymerase II promoter, ...
Component extracellular space, membrane, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (230)    Tissues (30)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 226
Northern blot 4
cDNA source data(134)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gnl3 ; ZFIN gnl3    NEW 
Molecular
reagents
All nucleic(135) cDNA(134) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000042354 (Evidence)
Entrez Gene 30877 (Evidence)
UniGene 88512
DFCI TC1715900, TC1596694, TC1574586, TC1612641, TC1614198
DoTS DT.101242927, DT.94262224, DT.493779, DT.94377892
NIA Mouse Gene Index U035363
Consensus CDS Project CCDS26905.1
International Mouse Phenotyping Consortium Status Gnl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042354 Ensembl Gene Model | MGI Sequence Detail 6656 C57BL/6J ±  kb
transcript ENSMUST00000037739 Ensembl | MGI Sequence Detail 1883 Not Applicable 
polypeptide ENSMUSP00000047119 Ensembl | MGI Sequence Detail 538 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006073 GTP binding domain
InterPro IPR014813 Guanine nucleotide-binding protein-like 3, N-terminal domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008117 guanine nucleotide-binding protein-like 3
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:198698 Meng L, et al., Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11415-20
All references(46)
Other
accession IDs
MGI:2387185

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory