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Zfp503 Gene Detail
Summary
  • Symbol
    Zfp503
  • Name
    zinc finger protein 503
  • Synonyms
    B830002A16Rik, Nolz-1, Nolz1, ZNF503, Zpo2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353644
    NCBI Gene: 218820
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:22034030-22039669 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 12.00 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353644
 protein coding gene Chr14:22034027-22039669 (-)
129S1/SvImJ ENSMUSG00200014148
 protein coding gene Chr14:13825633-13831259 (-)
A/J ENSMUSG00195021720
 protein coding gene Chr14:14906779-14912422 (-)
AKR/J ENSMUSG00220025024
 protein coding gene Chr14:14037384-14043026 (-)
BALB/cJ ENSMUSG00180037263
 protein coding gene Chr14:14005516-14011161 (-)
C3H/HeJ ENSMUSG00175020309
 protein coding gene Chr14:14062435-14068062 (-)
C57BL/6NJ ENSMUSG00215019204
 protein coding gene Chr14:14252292-14257936 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019011
 protein coding gene Chr14:14761379-14767023 (-)
CAST/EiJ ENSTCUG00005029267
 protein coding gene Chr14:14183472-14189097 (-)
CBA/J ENSMUSG00210025379
 protein coding gene Chr14:14298675-14304301 (-)
DBA/2J ENSMUSG00185036237
 protein coding gene Chr14:18583722-18589348 (-)
FVB/NJ ENSMUSG00205025933
 protein coding gene Chr14:14139099-14144726 (-)
JF1/MsJ ENSUMUG00000018927
 protein coding gene Chr14:25802515-25808147 (-)
LP/J ENSMUSG00230038943
 protein coding gene Chr14:25865445-25871071 (-)
NOD/ShiLtJ ENSMUSG00190031814
 protein coding gene Chr14:14297501-14303128 (-)
NZO/HlLtJ ENSMUSG00225035192
 protein coding gene Chr14:20085784-20091412 (-)
PWK/PhJ ENSLUMG00010020094
 protein coding gene Chr14:2442090-2447714 (-)
SPRET/EiJ ENSMSPG00010026610
 protein coding gene Chr14:15937308-15941642 (-)
WSB/EiJ ENSIUOG00005028560
 protein coding gene Chr14:14126637-14132273 (-)



Homology
more
  • Human Ortholog
    ZNF503, zinc finger protein 503
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF503, zinc finger protein 503
  • Synonyms
    Nlz2, NOLZ-1, NOLZ1, ZEPPO2, ZPO2
  • Links
    NCBI Gene ID: 84858
    UniProt: Q96F45

  • Chr Location
    10q22.2; chr10:75279725-75401916 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display neonatal lethality with abnormalities in the development of the striatum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1035
  • Tissues
    264
  • cDNA Data
    46
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 218820 NCBI Gene Model | MGI Sequence Detail 5640 C57BL/6J ±  kb
    transcript NM_145459 RefSeq | MGI Sequence Detail 4251 ZRU/MplStud  
    polypeptide Q7TMA2 UniProt | EBI | MGI Sequence Detail 652 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 47
      Primer pair 2
      Other 7
      Antibodies 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 32
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:384237 Wong-Fortunato J, et al., Zfp503 haploinsufficiency causes optic nerve coloboma in mice. Exp Eye Res. 2026 Mar 24;267:110985
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory