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Abt1 Gene Detail
Summary
  • Symbol
    Abt1
  • Name
    activator of basal transcription 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353636
    NCBI Gene: 30946
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:23602531-23608036 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 9.65 cM, cytoband A3.2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353636
 protein coding gene Chr13:23602531-23608036 (-)
129S1/SvImJ ENSMUSG00200029720
 protein coding gene Chr13:20733274-20738775 (-)
A/J ENSMUSG00195037433
 protein coding gene Chr13:19882404-19887905 (-)
AKR/J ENSMUSG00220029485
 protein coding gene Chr13:19703591-19709092 (-)
BALB/cJ ENSMUSG00180020460
 protein coding gene Chr13:20200915-20206416 (-)
C3H/HeJ ENSMUSG00175030143
 protein coding gene Chr13:20207195-20212696 (-)
C57BL/6NJ ENSMUSG00215012536
 protein coding gene Chr13:20359552-20365057 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018313
 protein coding gene Chr13:19258840-19261156 (-)
CAST/EiJ ENSTCUG00005010323
 protein coding gene Chr13:20385591-20391092 (-)
CBA/J ENSMUSG00210025580
 protein coding gene Chr13:20162482-20167983 (-)
DBA/2J ENSMUSG00185018834
 protein coding gene Chr13:21012191-21017692 (-)
FVB/NJ ENSMUSG00205042075
 protein coding gene Chr13:20002881-20008382 (-)
JF1/MsJ ENSUMUG00000010073
 protein coding gene Chr13:20633563-20639062 (-)
LP/J ENSMUSG00230018209
 protein coding gene Chr13:30309870-30315369 (-)
NOD/ShiLtJ ENSMUSG00190018718
 protein coding gene Chr13:19981115-19986614 (-)
NZO/HlLtJ ENSMUSG00225044192
 protein coding gene Chr13:24096885-24102386 (-)
PWK/PhJ ENSLUMG00010027727
 protein coding gene Chr13:19532979-19538486 (-)
SPRET/EiJ ENSMSPG00010016380
 protein coding gene Chr13:19311497-19315132 (-)
WSB/EiJ ENSIUOG00005030524
 protein coding gene Chr13:19492218-19497719 (-)



Homology
more
  • Human Ortholog
    ABT1, activator of basal transcription 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABT1, activator of basal transcription 1
  • Synonyms
    Esf2, hABT1
  • Links
    NCBI Gene ID: 29777
    UniProt: Q9ULW3

  • Chr Location
    6p22.2; chr6:26596953-26600739 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    840
  • Tissues
    168
  • cDNA Data
    62
  • Literature Summary
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 30946 NCBI Gene Model | MGI Sequence Detail 5506 C57BL/6J ±  kb
transcript NM_013924 RefSeq | MGI Sequence Detail 4456 C57BL/6  
polypeptide Q9QYL7 UniProt | EBI | MGI Sequence Detail 269 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000003591 activator of basal transcription 1
    (term hierarchy)
  • InterPro Domains
    IPR039119 ABT1/Esf2
    IPR034353 ABT1/ESF2, RNA recognition motif
    IPR060368 Activator of basal transcription 1, C-terminal region
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR060369 Pre-rRNA-processing protein ESF2-like coiled-coil region
    IPR035979 RNA-binding domain superfamily
Molecular
Reagents
less
  • All nucleic 64
    cDNA 62
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 47
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:368729 Wu M, et al., VIRMA-mediated m(6)A modification regulates forebrain formation through modulating ribosome biogenesis. Sci Adv. 2025 Jun 27;11(26):eadq9643
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory