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Angptl3 Gene Detail
Summary
  • Symbol
    Angptl3
  • Name
    angiopoietin-like 3
  • Synonyms
    hypl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353627
    NCBI Gene: 30924
  • Gene Overview
    MyGene.info: ANGPTL3
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr4:99030954-99046111 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      15158 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 45.60 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    ANGPTL3, angiopoietin like 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANGPTL3, angiopoietin like 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ANG-5, ANGPT5, ANL3, FHBL2
  • Links
    NCBI Gene ID: 27329
    neXtProt AC: NX_Q9Y5C1
    UniProt: Q9Y5C1

  • Chr Location
    1p31.3; chr1:62597487-62606305 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human ANGPTL3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display decreased plasma cholesterol and triglyceride levels. A spontaneous mutation results in a similar phenotype except that there is also a reduction in fat pad weight and decreased free fatty acid levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    12
  • Tissues
    12
  • cDNA Data
    50
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000008051 VEGA Gene Model | MGI Sequence Detail 15158 C57BL/6J ±  kb
    transcript OTTMUST00000019815 VEGA | MGI Sequence Detail 1482 Not Applicable  
    polypeptide OTTMUSP00000009086 VEGA | MGI Sequence Detail 455 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      143 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 1
      cDNA 50

      Microarray probesets 3
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:60238 Conklin D, et al., Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics. 1999 Dec 15;62(3):477-82
    • Latest
      J:242697 Haller JF, et al., ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance. J Lipid Res. 2017 Jun;58(6):1166-1173
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/10/2018
    MGI 6.12     		The Jackson Laboratory