Angptl3 MGI Mouse Gene Detail - MGI:1353627

Symbol

Angptl3
Name

angiopoietin-like 3
Synonyms

hypl

Feature Type

protein coding gene
IDs

MGI:1353627
NCBI Gene: 30924
Gene Overview

MyGene.info: ANGPTL3
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr4:99030954-99038192 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 45.60 cM
Mapping Data

6 experiments

SNPs within 2kb

70 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353627	protein coding gene	Chr4:99030954-99046111 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0028478	protein coding gene	Chr4:99239763-99254863 (+)
A/J	MGP_AJ_G0028441	protein coding gene	Chr4:95792629-95807791 (+)
AKR/J	MGP_AKRJ_G0028388	protein coding gene	Chr4:98117628-98132811 (+)
BALB/cJ	MGP_BALBcJ_G0028459	protein coding gene	Chr4:96040662-96058984 (+)
C3H/HeJ	MGP_C3HHeJ_G0028172	protein coding gene	Chr4:98913725-98928884 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028898	protein coding gene	Chr4:103011924-103027081 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026190	protein coding gene	Chr4:91180656-91187750 (+)
CAST/EiJ	MGP_CASTEiJ_G0027612	protein coding gene	Chr4:96702599-96718771 (+)
CBA/J	MGP_CBAJ_G0028141	protein coding gene	Chr4:106162051-106177156 (+)
DBA/2J	MGP_DBA2J_G0028291	protein coding gene	Chr4:95528597-95543651 (+)
FVB/NJ	MGP_FVBNJ_G0028258	protein coding gene	Chr4:94370101-94385169 (+)
LP/J	MGP_LPJ_G0028391	protein coding gene	Chr4:99559367-99575590 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028286	protein coding gene	Chr4:111898290-111916289 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028936	protein coding gene	Chr4:98358644-98374053 (+)
PWK/PhJ	MGP_PWKPhJ_G0027337	protein coding gene	Chr4:93669401-93684799 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027158	protein coding gene	Chr4:95803104-95819744 (+)
WSB/EiJ	MGP_WSBEiJ_G0027690	protein coding gene	Chr4:98494513-98510773 (+)

Human Ortholog

ANGPTL3, angiopoietin like 3

Vertebrate Orthologs

10

Human Ortholog

ANGPTL3, angiopoietin like 3
Orthology source: HGNC, HomoloGene
Synonyms

ANG-5, ANGPT5, ANL3, FHBL2
Links

HGNC:491

NCBI Gene ID: 27329

neXtProt AC: NX_Q9Y5C1

UniProt: Q9Y5C1
Chr Location

1p31.3; chr1:62597487-62606305 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8499
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ANGPTL3
Gene Tree

Angptl3

Diseases

1 with human ANGPTL3 associations

				Human Disease	Mouse Models
				familial hypobetalipoproteinemia 2 IDs familial hypobetalipoproteinemia 2 DOID:0111061 OMIM:605019

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 4 alleles in 4 genetic backgrounds
5 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

2
Radiation induced

1
Spontaneous

1
Targeted

9
Genomic Mutations

4 involving Angptl3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a disruption in this gene display decreased plasma cholesterol and triglyceride levels. A spontaneous mutation results in a similar phenotype except that there is also a reduction in fat pad weight and decreased free fatty acid levels.

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All GO Annotations

41
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

19
Tissues

16
cDNA Data

50
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase angptl3

ZFIN angptl3

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Angptl3 interacts with 31 markers (Mir22, Mir26a-2, Mir26b, ...) View All

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS38817.1
UniGene

28341

Ensembl

ENSMUSG00000028553 (Evidence)
NCBI Gene

30924

			Length	Strain/Species	Flank
genomic	30924	NCBI Gene Model \| MGI Sequence Detail	7239	C57BL/6J	± kb
transcript	NM_013913	RefSeq \| MGI Sequence Detail	1609	C57BL/6
polypeptide	Q9R182	UniProt \| EBI \| MGI Sequence Detail	455	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004028 angiopoietin-related protein 3

(term hierarchy)
InterPro Domains

IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain

IPR036056 Fibrinogen-like, C-terminal

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All nucleic 51

Genomic 1

cDNA 50

Microarray probesets 3

Summaries

All 56

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 20
Earliest

J:60238 Conklin D, et al., Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics. 1999 Dec 15;62(3):477-82
Latest

J:242697 Haller JF, et al., ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance. J Lipid Res. 2017 Jun;58(6):1166-1173

TSS for Angptl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37909	Chr4:99030878-99030883 (+)	-73 bp
Tssr37910	Chr4:99030907-99030944 (+)	-28 bp
Tssr37911	Chr4:99030946-99030961 (+)	0 bp
Tssr37912	Chr4:99031161-99031172 (+)	213 bp
Tssr37913	Chr4:99031196-99031208 (+)	248 bp
Tssr37914	Chr4:99031286-99031303 (+)	341 bp
Tssr37915	Chr4:99031336-99031347 (+)	388 bp
Tssr37916	Chr4:99031417-99031437 (+)	473 bp
Tssr37917	Chr4:99031462-99031474 (+)	514 bp
Tssr37918	Chr4:99033231-99033243 (+)	2,283 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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