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Angptl3
Gene Detail
Symbol

Name
ID
Angptl3
angiopoietin-like 3
MGI:1353627
Synonyms
hypl
Feature Type
protein coding gene
Genetic Map
Chromosome 4
45.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:99030954-99046111 bp, + strand
From VEGA annotation of GRCm38

  15158 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8499  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ANGPTL3
Gene Tree: Angptl3

Human
homologs
ANGPTL3, angiopoietin-like 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 27329
neXtProt AC: NX_Q9Y5C1

Human Synonyms: ANG-5, ANGPT5, ANL3, FHBL2

Human Chr (Location): 1p31.3; chr1:62597487-62606305 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ANGPTL3

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Spontaneous(1) Targeted(7)
Genomic Mutations involving Angptl3 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a disruption in this gene display decreased plasma cholesterol and triglyceride levels. A spontaneous mutation results in a similar phenotype except that there is also a reduction in fat pad weight and decreased free fatty acid levels.
 
Interactions
Angptl3 interacts with 31 markers (Mir22, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process acylglycerol homeostasis, artery morphogenesis, ...
Component cell surface, early endosome, ...
Function enzyme inhibitor activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (12)    Tissues (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 12
cDNA source data(48)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase angptl3 ; ZFIN angptl3    NEW 
Molecular
reagents
All nucleic(49) Genomic(1) cDNA(48)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000008051 (Evidence)
Ensembl Gene Model ENSMUSG00000028553 (Evidence)
Entrez Gene 30924 (Evidence)
UniGene 28341
DFCI TC1606714, TC1579994
DoTS DT.533722, DT.94214108, DT.91326172
NIA Mouse Gene Index U004527
Consensus CDS Project CCDS38817.1
International Mouse Phenotyping Consortium Status Angptl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008051 VEGA Gene Model | MGI Sequence Detail 15158 C57BL/6J ±  kb
transcript OTTMUST00000019815 VEGA | MGI Sequence Detail 1482 Not Applicable 
polypeptide OTTMUSP00000009086 VEGA | MGI Sequence Detail 455 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
Protein Ontology PR:000004028 angiopoietin-related protein 3
References
(Earliest) J:60238 Conklin D, et al., Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics. 1999 Dec 15;62(3):477-82
(Latest) J:203527 Essalmani R, et al., Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. J Biol Chem. 2013 Sep 13;288(37):26410-8
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory