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Angptl3
Gene Detail
 Symbol
Name
ID
Angptl3
angiopoietin-like 3
MGI:1353627
Synonyms hypl
Feature Type protein coding gene
Genetic Map
Chromosome 4
45.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:99030954-99046111 bp, + strand
From VEGA annotation of GRCm38

  15158 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8499  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Angptl3

Human
homologs
Human Homolog ANGPTL3, angiopoietin-like 3
NCBI Gene ID 27329
neXtProt AC  NX_Q9Y5C1
Human Synonyms  ANG-5, ANGPT5, ANL3, FHBL2
Human Chr (Location)  1p31.3; chr1:62597487-62606305 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ANGPTL3
Alleles
and
phenotypes
All alleles(7) : Targeted(6) Spontaneous(1)
 
Mice homozygous for a disruption in this gene display decreased plasma cholesterol and triglyceride levels. A spontaneous mutation results in a similar phenotype except that there is also a reduction in fat pad weight and decreased free fatty acid levels.
 
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process acylglycerol homeostasis, artery morphogenesis, ...
Component cell surface, extracellular region, ...
Function enzyme inhibitor activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (12)    Tissues (12)   
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
Northern blot 12
cDNA source data(48)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(49) Genomic(1) cDNA(48)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008051 (Evidence)
Ensembl Gene ModelENSMUSG00000028553 (Evidence)
Entrez Gene30924 (Evidence)
UniGene28341
DFCITC1579994, TC1606714
DoTSDT.533722, DT.91326172, DT.94214108
NIA Mouse Gene IndexU004527
Consensus CDS ProjectCCDS38817.1
International Mouse Knockout Project StatusAngptl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008051 VEGA Gene Model | MGI Sequence Detail 15158 C57BL/6J ±  kb
transcript OTTMUST00000019815 VEGA | MGI Sequence Detail 1482 Not Applicable 
polypeptide OTTMUSP00000009086 VEGA | MGI Sequence Detail 455 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
Protein Ontology PR:000004028 angiopoietin-related protein 3
References (Earliest) J:60238 Conklin D, et al., Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics. 1999 Dec 15;62(3):477-82
(Latest) J:192349 Quagliarini F, et al., Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19751-6
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory