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Angptl3 Gene Detail
Summary
  • Symbol
    Angptl3
  • Name
    angiopoietin-like 3
  • Synonyms
    hypl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353627
    NCBI Gene: 30924
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:98919191-98926429 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 45.60 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353627
 protein coding gene Chr4:98919191-98934348 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028478
 protein coding gene Chr4:99239763-99254863 (+)
A/J MGP_AJ_G0028441
 protein coding gene Chr4:95792629-95807791 (+)
AKR/J MGP_AKRJ_G0028388
 protein coding gene Chr4:98117628-98132811 (+)
BALB/cJ MGP_BALBcJ_G0028459
 protein coding gene Chr4:96040662-96058984 (+)
C3H/HeJ MGP_C3HHeJ_G0028172
 protein coding gene Chr4:98913725-98928884 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028898
 protein coding gene Chr4:103011924-103027081 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026190
 protein coding gene Chr4:91180656-91187750 (+)
CAST/EiJ MGP_CASTEiJ_G0027612
 protein coding gene Chr4:96702599-96718771 (+)
CBA/J MGP_CBAJ_G0028141
 protein coding gene Chr4:106162051-106177156 (+)
DBA/2J MGP_DBA2J_G0028291
 protein coding gene Chr4:95528597-95543651 (+)
FVB/NJ MGP_FVBNJ_G0028258
 protein coding gene Chr4:94370101-94385169 (+)
LP/J MGP_LPJ_G0028391
 protein coding gene Chr4:99559367-99575590 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028286
 protein coding gene Chr4:111898290-111916289 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028936
 protein coding gene Chr4:98358644-98374053 (+)
PWK/PhJ MGP_PWKPhJ_G0027337
 protein coding gene Chr4:93669401-93684799 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027158
 protein coding gene Chr4:95803104-95819744 (+)
WSB/EiJ MGP_WSBEiJ_G0027690
 protein coding gene Chr4:98494513-98510773 (+)



Homology
more
  • Human Ortholog
    ANGPTL3, angiopoietin like 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANGPTL3, angiopoietin like 3
  • Synonyms
    ANG-5, ANGPT5, ANL3, FHBL2
  • Links
    NCBI Gene ID: 27329
    neXtProt AC: NX_Q9Y5C1
    UniProt: Q9Y5C1

  • Chr Location
    1p31.3; chr1:62597487-62606305 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human ANGPTL3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display decreased plasma cholesterol and triglyceride levels. A spontaneous mutation results in a similar phenotype except that there is also a reduction in fat pad weight and decreased free fatty acid levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    76
  • cDNA Data
    50
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30924 NCBI Gene Model | MGI Sequence Detail 7239 C57BL/6J ±  kb
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004028 angiopoietin-related protein 3
      (term hierarchy)
    • InterPro Domains
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR036056 Fibrinogen-like, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 1
      cDNA 50
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 24
    • Earliest
      J:60238 Conklin D, et al., Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics. 1999 Dec 15;62(3):477-82
    • Latest
      J:323142 Ma Y, et al., Podocyte protection by Angptl3 knockout via inhibiting ROS/GRP78 pathway in LPS-induced acute kidney injury. Int Immunopharmacol. 2022 Apr;105:108549
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/10/2022
    MGI 6.19     		The Jackson Laboratory