Angptl3 MGI Mouse Gene Detail - MGI:1353627

Angptl3 Gene Detail

Symbol

Angptl3
Name

angiopoietin-like 3
Synonyms

hypl

Feature Type

protein coding gene
IDs

MGI:1353627
NCBI Gene: 30924
Gene Overview

MyGene.info: ANGPTL3

Sequence Map

Chr4:99030954-99046111 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

15158 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 45.60 cM
Mapping Data

6 experiments

Human Ortholog

ANGPTL3, angiopoietin like 3

Vertebrate Orthologs

10

Human Ortholog

ANGPTL3, angiopoietin like 3
Orthology source: HomoloGene, HGNC
Synonyms

ANG-5, ANGPT5, ANL3, FHBL2
Links

HGNC:491

NCBI Gene ID: 27329

neXtProt AC: NX_Q9Y5C1
Chr Location

1p31.3; chr1:62597487-62606305 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 8499
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: ANGPTL3
Gene Tree

Angptl3

Diseases

1 with human ANGPTL3 associations

				Human Disease	Mouse Models
				Hypobetalipoproteinemia, Familial, 2; FHBL2 OMIM: 605019

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 4 alleles in 4 genetic backgrounds
5 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Radiation induced

1
Spontaneous

1
Targeted

8
Genomic Mutations

4 involving Angptl3
Incidental Mutations

Mutagenetix , APF , CvDC

Mice homozygous for a disruption in this gene display decreased plasma cholesterol and triglyceride levels. A spontaneous mutation results in a similar phenotype except that there is also a reduction in fat pad weight and decreased free fatty acid levels.

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All GO Annotations

41
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

12
Tissues

12
cDNA Data

48
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase angptl3

ZFIN angptl3

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Angptl3 interacts with 31 markers (Mir22, Mir26a-2, Mir26b, ...) View All

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All Sequences

24
RefSeq

2
UniProt

2
CCDS

CCDS38817.1
UniGene

28341

			Length	Strain/Species	Flank
genomic	OTTMUSG00000008051	VEGA Gene Model \| MGI Sequence Detail	15158	C57BL/6J	± kb
transcript	OTTMUST00000019815	VEGA \| MGI Sequence Detail	1482	Not Applicable
polypeptide	OTTMUSP00000009086	VEGA \| MGI Sequence Detail	455	Not Applicable

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SNPs within 2kb

143 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000004028 angiopoietin-related protein 3
InterPro Domains

IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain

IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1

IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2

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All nucleic 49

Genomic 1

cDNA 48

Microarray probesets 3

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 16
Earliest

J:60238 Conklin D, et al., Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics. 1999 Dec 15;62(3):477-82
Latest

J:226803 Wang Y, et al., Hepatic ANGPTL3 regulates adipose tissue energy homeostasis. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11630-5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/13/2016 MGI 6.05