Angptl3
Gene Detail

Symbol Name ID

Angptl3 angiopoietin-like 3 MGI:1353627

Synonyms

hypl

Feature Type

protein coding gene

Genetic Map

Chromosome 4

45.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr4:99030954-99046111 bp, + strand From VEGA annotation of GRCm38   15158 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8499  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Angptl3

Human homologs

Human Homolog		ANGPTL3, angiopoietin-like 3
NCBI Gene ID		27329
neXtProt AC		NX_Q9Y5C1
Human Synonyms		ANG-5, ANGPT5, ANL3, FHBL2
Human Chr (Location)		1p31.3; chr1:62597487-62606305 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human ANGPTL3

Mutations, alleles, and phenotypes

All mutations/alleles(7) : Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a disruption in this gene display decreased plasma cholesterol and triglyceride levels. A spontaneous mutation results in a similar phenotype except that there is also a reduction in fat pad weight and decreased free fatty acid levels.

 

Interactions

Angptl3 interacts with 31 markers (Mir22, Mir26a-2, Mir26b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	acylglycerol homeostasis, artery morphogenesis, ...
Component	cell surface, extracellular region, ...
Function	enzyme inhibitor activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (12)    Tissues (12)   
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
Northern blot	12

cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(49) Genomic(1) cDNA(48)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000008051 (Evidence)
Ensembl Gene Model	ENSMUSG00000028553 (Evidence)
Entrez Gene	30924 (Evidence)
UniGene	28341
DFCI	TC1579994, TC1606714
DoTS	DT.533722, DT.91326172, DT.94214108
NIA Mouse Gene Index	U004527
Consensus CDS Project	CCDS38817.1
International Mouse Knockout Project Status	Angptl3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008051	VEGA Gene Model | MGI Sequence Detail	15158	C57BL/6J
transcript	OTTMUST00000019815	VEGA | MGI Sequence Detail	1482	Not Applicable
polypeptide	OTTMUSP00000009086	VEGA | MGI Sequence Detail	455	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

SNPs within 2kb(143 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro	IPR014715	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
Protein Ontology	PR:000004028	angiopoietin-related protein 3

References

(Earliest) J:60238 Conklin D, et al., Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics. 1999 Dec 15;62(3):477-82
(Latest) J:192349 Quagliarini F, et al., Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19751-6
All references(44)