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Apln
Gene Detail
Symbol

Name
ID
Apln
apelin
MGI:1353624
Synonyms
6030430G11Rik
Feature Type
protein coding gene
Genetic Map
Chromosome X
25.48 cM, cytoband A3.2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:48025146-48034853 bp, - strand
From VEGA annotation of GRCm38

  9708 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8498  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

Gene Tree: Apln

Human
homologs
Human Homolog APLN, apelin
NCBI Gene ID 8862
neXtProt AC  NX_Q9ULZ1
Human Synonyms  APEL, XNPEP2
Human Chr (Location)  Xq25; chrX:129645259-129654956 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
 
Mice homozygous for one null allele display narrower small vessels and a reduction in the density of vessels in some capillary beds. Mice homozygous or hemizygous for a second null allele display impaired cardiac function with age.
 
Interactions
Apln interacts with 329 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process drinking behavior, feeding behavior, ...
Component extracellular space, perinuclear region of cytoplasm
Function apelin receptor binding, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (187)    Tissues (38)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 187
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017506 (Evidence)
Ensembl Gene ModelENSMUSG00000037010 (Evidence)
Entrez Gene30878 (Evidence)
UniGene29262
DFCITC1583233, TC1651342
DoTSDT.101202997, DT.50316975
NIA Mouse Gene IndexU039348
Consensus CDS ProjectCCDS40958.1
International Mouse Knockout Project StatusApln
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017506 VEGA Gene Model | MGI Sequence Detail 9708 C57BL/6J ±  kb
transcript OTTMUST00000042500 VEGA | MGI Sequence Detail 3149 Not Applicable 
polypeptide OTTMUSP00000019097 VEGA | MGI Sequence Detail 77 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026155 Apelin
Protein Ontology PR:000004135 apelin
References
(Earliest) J:50460 Tatemoto K, et al., Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998 Oct 20;251(2):471-6
(Latest) J:212075 Tian X, et al., Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart. Science. 2014 Jul 4;345(6192):90-4
All references(71)
Other
accession IDs
MGI:1925124

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory