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Slc46a2 Gene Detail
Summary
  • Symbol
    Slc46a2
  • Name
    solute carrier family 46, member 2
  • Synonyms
    5430429N04Rik, Ly110, Tscot, TSO-1C12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353616
    NCBI Gene: 30936
Location & Maps
more
  • Sequence Map
    Chr4:59905126-59915056 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9931 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 32.81 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC46A2, solute carrier family 46 member 2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    SLC46A2, solute carrier family 46 member 2
    Orthology source: HomoloGene
  • Synonyms
    Ly110, TSCOT
  • Links
    NCBI Gene ID: 57864
    neXtProt AC: NX_Q9BY10

  • Chr Location
    9q32; chr9:112878920-112890942 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
About one-third of homozygotes carrying a reporter allele that results in a small deletion within exon 1 display a slight reduction in total thymocyte yield at 6 weeks of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007404 VEGA Gene Model | MGI Sequence Detail 9931 C57BL/6J ±  kb
transcript OTTMUST00000017134 VEGA | MGI Sequence Detail 2833 Not Applicable  
polypeptide OTTMUSP00000007912 VEGA | MGI Sequence Detail 479 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    101 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015151 thymic stromal cotransporter
  • InterPro Domains
    IPR011701 Major facilitator superfamily
    IPR020846 Major facilitator superfamily domain
    IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG
Molecular
Reagents
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  • All nucleic 19
    cDNA 16
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1914810
References
more
  • Summaries
    All 27
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:60551 Kim MG, et al., A putative 12 transmembrane domain cotransporter expressed in thymic cortical epithelial cells. J Immunol. 2000 Mar 15;164(6):3185-92
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory