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Hnf4g Gene Detail
Summary
  • Symbol
    Hnf4g
  • Name
    hepatocyte nuclear factor 4, gamma
  • Synonyms
    NR2A2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353604
    NCBI Gene: 30942
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:3508030-3658052 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      150023 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 1.82 cM, cytoband A
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    HNF4G, hepatocyte nuclear factor 4 gamma
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HNF4G, hepatocyte nuclear factor 4 gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NR2A2, NR2A3
  • Links
    NCBI Gene ID: 3174
    neXtProt AC: NX_Q14541
    UniProt: Q14541

  • Chr Location
    8q21.13; chr8:75407567-75566834 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are less inclined to build nests, spend more time in a passive state during the forced swim test, and display a reduction in energy expenditure and night time activity that results in increased body weight despite adecreased intake of food and water.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020282 VEGA Gene Model | MGI Sequence Detail 150023 C57BL/6J ±  kb
    transcript OTTMUST00000048142 VEGA | MGI Sequence Detail 2327 Not Applicable  
    polypeptide OTTMUSP00000021982 VEGA | MGI Sequence Detail 462 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1171 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR003068 Transcription factor COUP
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 1
      cDNA 9

      Microarray probesets 4
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 10
      Gene Ontology 4
      Phenotypes 3
    • Earliest
      J:60242 Taraviras S, et al., Primary structure, chromosomal mapping, expression and transcriptional activity of murine hepatocyte nuclear factor 4gamma. Biochim Biophys Acta. 2000 Jan 31;1490(1-2):21-32
    • Latest
      J:246317 Baraille F, et al., Glucose Tolerance Is Improved in Mice Invalidated for the Nuclear Receptor HNF-4gamma: A Critical Role for Enteroendocrine Cell Lineage. Diabetes. 2015 Aug;64(8):2744-56

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory