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Hnf4g
Gene Detail
 Symbol
Name
ID
Hnf4g
hepatocyte nuclear factor 4, gamma
MGI:1353604
Synonyms NR2A2
Feature Type protein coding gene
Genetic Map
Chromosome 3
1.82 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:3508030-3658052 bp, + strand
From VEGA annotation of GRCm38

  150023 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37886  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: retinoic X receptor-like nuclear receptor
Gene Tree: Hnf4g

Human
homologs
Human Homolog HNF4G, hepatocyte nuclear factor 4, gamma
NCBI Gene ID 3174
neXtProt AC  NX_Q14541
Human Synonyms  NR2A2, NR2A3
Human Chr (Location)  8q21.11; chr8:75539968-75566843 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are less inclined to build nests, spend more time in a passive state during the forced swim test, and display a reduction in energy expenditure and night time activity that results in increased body weight despite a decreased intake of food and water.
 
Interactions
Hnf4g interacts with 353 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process positive regulation of transcription, DNA-templated, regulation of transcription, DNA-templated, ...
Component nucleus, transcription factor complex
Function DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (111)    Tissues (63)    Images (21)
Theiler Stages: 17, 18, 21, 22, 23, 24, 27, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 108
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) Genomic(1) cDNA(9)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000020282 (Evidence)
Ensembl Gene ModelENSMUSG00000017688 (Evidence)
Entrez Gene30942 (Evidence)
UniGene330897
DFCITC1596865
DoTSDT.91328257
NIA Mouse Gene IndexU003003
Consensus CDS ProjectCCDS17226.1
International Mouse Knockout Project StatusHnf4g
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020282 VEGA Gene Model | MGI Sequence Detail 150023 C57BL/6J ±  kb
transcript OTTMUST00000048142 VEGA | MGI Sequence Detail 2327 Not Applicable 
polypeptide OTTMUSP00000021982 VEGA | MGI Sequence Detail 462 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(1214 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1228)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR003068 Transcription factor COUP
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000008655 hepatocyte nuclear factor 4-gamma
References (Earliest) J:60242 Taraviras S, et al., Primary structure, chromosomal mapping, expression and transcriptional activity of murine hepatocyte nuclear factor 4gamma. Biochim Biophys Acta. 2000 Jan 31;1490(1-2):21-32
(Latest) J:192058 Jonckheere N, et al., GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells. Biochim Biophys Acta. 2012 Aug;1819(8):869-76
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory