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Cbx8 Gene Detail
Summary
  • Symbol
    Cbx8
  • Name
    chromobox 8
  • Synonyms
    Pc3, polycomb 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353589
    NCBI Gene: 30951
  • Gene Overview
    MyGene.info: CBX8
Location & Maps
more
  • Sequence Map
    Chr11:119036305-119040969 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4665 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.33 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CBX8, chromobox 8
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CBX8, chromobox 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PC3, RC1
  • Links
    NCBI Gene ID: 57332
    neXtProt AC: NX_Q9HC52

  • Chr Location
    17q25.3; chr17:79794377-79797116 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit impaired MLL-AF9 transformation but are otherwise viable with normal hematopoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003999 VEGA Gene Model | MGI Sequence Detail 4665 C57BL/6J ±  kb
transcript OTTMUST00000008885 VEGA | MGI Sequence Detail 3580 Not Applicable  
polypeptide OTTMUSP00000004337 VEGA | MGI Sequence Detail 362 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    2 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 27
    Genomic 1
    cDNA 26

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 4
  • Earliest
    J:60239 Hemenway CS, et al., Identification and analysis of a third mouse Polycomb gene, MPc3. Gene. 2000 Jan 25;242(1-2):31-40
  • Latest
    J:222656 Creppe C, et al., A Cbx8-containing polycomb complex facilitates the transition to gene activation during ES cell differentiation. PLoS Genet. 2014 Dec;10(12):e1004851

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory