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Ddx25
Gene Detail
 Symbol
Name
ID
Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
MGI:1353582
Synonyms GRTH
Feature Type protein coding gene
Genetic Map
Chromosome 9
20.31 cM, cytoband A3-A5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:35541847-35558528 bp, - strand
From VEGA annotation of GRCm38

  16682 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8310  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: ATP-dependent RNA helicase DHH1
Gene Tree: Ddx25

Human
homologs
Human Homolog DDX25, DEAD (Asp-Glu-Ala-Asp) box helicase 25
NCBI Gene ID 29118
neXtProt AC  NX_Q9UHL0
Human Synonyms  GRTH
Human Chr (Location)  11q24; chr11:125904366-125923110 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display male infertility, arrest of spermatogenesis at step 8, abnormal Leydig cells, and increased germ cell apoptosis in males.
 
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process ATP catabolic process, cell differentiation, ...
Component chromatoid body, cytoplasm, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(45)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(45) cDNA(45)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000044699 (Evidence)
Ensembl Gene ModelENSMUSG00000032101 (Evidence)
Entrez Gene30959 (Evidence)
UniGene291723
DFCITC1579436
DoTSDT.485977
NIA Mouse Gene IndexU030669
EC3.6.4.13
Consensus CDS ProjectCCDS52753.1
International Mouse Knockout Project StatusDdx25
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044699 VEGA Gene Model | MGI Sequence Detail 16682 C57BL/6J ±  kb
transcript OTTMUST00000117539 VEGA | MGI Sequence Detail 1734 Not Applicable 
polypeptide OTTMUSP00000065708 VEGA | MGI Sequence Detail 484 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(130 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR014014 RNA helicase, DEAD-box type, Q motif
Protein Ontology PR:000006361 ATP-dependent RNA helicase DDX25
References (Earliest) J:59130 Tang PZ, et al., A novel gonadotropin-regulated testicular RNA helicase. A new member of the dead-box family. J Biol Chem. 1999 Dec 31;274(53):37932-40
(Latest) J:203322 Hussain S, et al., The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation. Mol Cell Biol. 2013 Apr;33(8):1561-70
All references(36)
Other
accession IDs
MGI:2143278

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory