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Ddx25 Gene Detail
Summary
  • Symbol
    Ddx25
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
  • Synonyms
    GRTH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353582
    NCBI Gene: 30959
Location & Maps
more
  • Sequence Map
    Chr9:35536647-35558528 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21882 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DDX25, DEAD-box helicase 25
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DDX25, DEAD-box helicase 25
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GRTH
  • Links
    NCBI Gene ID: 29118
    neXtProt AC: NX_Q9UHL0

  • Chr Location
    11q24; chr11:125904366-125923110 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    3
  • Incidental Mutations
Homozygous null mice display male infertility, arrest of spermatogenesis at step 8, abnormal Leydig cells, and increased germ cell apoptosis in males.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044699 VEGA Gene Model | MGI Sequence Detail 21882 C57BL/6J ±  kb
transcript OTTMUST00000117539 VEGA | MGI Sequence Detail 6934 Not Applicable  
polypeptide OTTMUSP00000065708 VEGA | MGI Sequence Detail 484 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    205 from dbSNP Build 137
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006361 ATP-dependent RNA helicase DDX25
  • EC
  • InterPro Domains
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
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  • All nucleic 45
    cDNA 45

    Microarray probesets 4
Other
Accession IDs
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MGI:2143278
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:59130 Tang PZ, et al., A novel gonadotropin-regulated testicular RNA helicase. A new member of the dead-box family. J Biol Chem. 1999 Dec 31;274(53):37932-40
  • Latest
    J:203322 Hussain S, et al., The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation. Mol Cell Biol. 2013 Apr;33(8):1561-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory