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Ddx25
Gene Detail
Symbol

Name
ID
Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
MGI:1353582
Synonyms
GRTH
Feature Type
protein coding gene
Genetic Map
Chromosome 9
20.31 cM, cytoband A3-A5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:35536647-35558528 bp, - strand
From VEGA annotation of GRCm38

  21882 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8310  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: DDX25
Protein SuperFamily: ATP-dependent RNA helicase DHH1
Gene Tree: Ddx25

Human
homologs
DDX25, DEAD (Asp-Glu-Ala-Asp) box helicase 25
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 29118
neXtProt AC: NX_Q9UHL0

Human Synonyms: GRTH

Human Chr (Location): 11q24; chr11:125904366-125923110 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display male infertility, arrest of spermatogenesis at step 8, abnormal Leydig cells, and increased germ cell apoptosis in males.
 
Interactions
Ddx25 interacts with 24 markers (Mir93, Mir96, Mir146, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell differentiation, mRNA export from nucleus, ...
Component chromatoid body, cytoplasm, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(45)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ddx25    NEW 
Molecular
reagents
All nucleic(45) cDNA(45)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000044699 (Evidence)
Ensembl Gene Model ENSMUSG00000032101 (Evidence)
Entrez Gene 30959 (Evidence)
UniGene 291723
DFCI TC1579436
DoTS DT.485977
NIA Mouse Gene Index U030669
EC 3.6.4.13
Consensus CDS Project CCDS52753.1
International Mouse Phenotyping Consortium Status Ddx25
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044699 VEGA Gene Model | MGI Sequence Detail 21882 C57BL/6J ±  kb
transcript OTTMUST00000117539 VEGA | MGI Sequence Detail 6934 Not Applicable 
polypeptide OTTMUSP00000065708 VEGA | MGI Sequence Detail 484 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(205 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011545 DEAD/DEAH box helicase domain
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR014014 RNA helicase, DEAD-box type, Q motif
Protein Ontology PR:000006361 ATP-dependent RNA helicase DDX25
References
(Earliest) J:59130 Tang PZ, et al., A novel gonadotropin-regulated testicular RNA helicase. A new member of the dead-box family. J Biol Chem. 1999 Dec 31;274(53):37932-40
(Latest) J:203322 Hussain S, et al., The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation. Mol Cell Biol. 2013 Apr;33(8):1561-70
All references(36)
Other
accession IDs
MGI:2143278

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory