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Foxe3 Gene Detail
Summary
  • Symbol
    Foxe3
  • Name
    forkhead box E3
  • Synonyms
    FREAC8, rct
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353569
    NCBI Gene: 30923
  • Gene Overview
    MyGene.info: FOXE3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:114925147-114926013 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 52.73 cM, cytoband C7
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    19 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353569
protein coding gene Chr4:114925147-114926013 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028591
protein coding gene Chr4:115684386-115685252 (-)
A/J MGP_AJ_G0028553
protein coding gene Chr4:111268939-111269805 (-)
AKR/J MGP_AKRJ_G0028501
protein coding gene Chr4:113572938-113573804 (-)
BALB/cJ MGP_BALBcJ_G0028573
protein coding gene Chr4:111910699-111911565 (-)
C3H/HeJ MGP_C3HHeJ_G0028287
protein coding gene Chr4:115187737-115188603 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029017
protein coding gene Chr4:120160574-120161440 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026301
protein coding gene Chr4:105369285-105370151 (-)
CAST/EiJ MGP_CASTEiJ_G0027724
protein coding gene Chr4:112606873-112607739 (-)
CBA/J MGP_CBAJ_G0028255
protein coding gene Chr4:123265473-123266339 (-)
DBA/2J MGP_DBA2J_G0028404
protein coding gene Chr4:111916651-111917523 (-)
FVB/NJ MGP_FVBNJ_G0028372
protein coding gene Chr4:110386846-110387712 (-)
LP/J MGP_LPJ_G0028505
protein coding gene Chr4:115888099-115888965 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028397
protein coding gene Chr4:128417428-128418294 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029053
protein coding gene Chr4:114819299-114820165 (-)
PWK/PhJ MGP_PWKPhJ_G0027449
protein coding gene Chr4:108702615-108703481 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027273
protein coding gene Chr4:111206857-111207720 (-)
WSB/EiJ MGP_WSBEiJ_G0027802
protein coding gene Chr4:114603477-114604343 (-)



Homology
more
  • Human Ortholog
    FOXE3, forkhead box E3
  • Vertebrate Orthologs
    5
  • Human Ortholog
    FOXE3, forkhead box E3
    Orthology source: HGNC
  • Synonyms
    AAT11, ASGD2, CTRCT34, FKHL12, FREAC8
  • Links
    NCBI Gene ID: 2301
    neXtProt AC: NX_Q13461
    UniProt: Q13461

  • Chr Location
    1p33; chr1:47416072-47418052 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Foxe3 mouse models; 3 with human FOXE3 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 4 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    2 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous or null mutation display microphthalmia, fusion of the lens and cornea, and other corneal and lens abnormalities. Null mice have reduced smooth muscle cell density in the ascending aorta and show aortic remodeling and rupture of the aorta after TAC.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30923 NCBI Gene Model | MGI Sequence Detail 867 C57BL/6J ±  kb
    transcript NM_015758 RefSeq | MGI Sequence Detail 867 C57BL/6  
    polypeptide Q9QY14 UniProt | EBI | MGI Sequence Detail 288 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 2
      cDNA 5
      Primer pair 3
      Other 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-9263, MGI:1890502, MGI:95261
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 50
      Diseases 2
      Gene Ontology 12
      Phenotypes 20
    • Earliest
      J:6131 Sanyal S, et al., Dysgenetic lens (dyl)--a new gene in the mouse. Invest Ophthalmol Vis Sci. 1979 Jun;18(6):642-5
    • Latest
      J:264269 Azimi M, et al., Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens. Differentiation. 2018 Jul - Aug;102:40-52

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory