Foxe3
Gene Detail

Symbol Name ID

Foxe3 forkhead box E3 MGI:1353569

Synonyms

FREAC8, rct

Feature Type

protein coding gene

Genetic Map

Chromosome 4

52.73 cM, cytoband C7
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr4:114925147-114926013 bp, - strand From VEGA annotation of GRCm38   867 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32145  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle

Gene Tree: Foxe3

Human homologs

Human Homolog		FOXE3, forkhead box E3
NCBI Gene ID		2301
neXtProt AC		NX_Q13461
Human Synonyms		FKHL12, FREAC8
Human Chr (Location)		1p32; chr1:47881744-47883724 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human FOXE3

Alleles and phenotypes

All alleles(4) : Targeted(2) Spontaneous(2)
 

Homozygotes for a spontaneous mutation exhibit microphthalmia, fusion of the lens and cornea, and other lens abnormalities. Homozygotes for a null mutation display microphthalmia, fusion of the lens and cornea, other corneal and lens abnormalities, and may fail to open their eyes.

 
Human Diseases Modeled Using Mouse Foxe3 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	camera-type eye development, cell development, ...
Component	nucleus, transcription factor complex
Function	DNA binding, DNA binding, bending, ...

External Resources: FuncBase

Expression

Literature Summary: (32 records)
Data Summary: Results (95)    Tissues (95)    Images (13)
Theiler Stages: 17, 22

Assay Type	Results
RNA in situ	95

cDNA source data(3)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(6) Genomic(2) cDNA(3) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000008588 (Evidence)
Ensembl Gene Model	ENSMUSG00000044518 (Evidence)
Entrez Gene	30923 (Evidence)
UniGene	377122
DoTS	DT.91439242
Consensus CDS Project	CCDS18483.1
International Mouse Knockout Project Status	Foxe3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008588	VEGA Gene Model | MGI Sequence Detail	867	C57BL/6J
transcript	OTTMUST00000019473	VEGA | MGI Sequence Detail	867	Not Applicable
polypeptide	OTTMUSP00000008935	VEGA | MGI Sequence Detail	288	Not Applicable

All sequences(14) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(14 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000007620	forkhead box protein E3

References

(Earliest) J:6131 Sanyal S, et al., Dysgenetic lens (dyl)--a new gene in the mouse. Invest Ophthalmol Vis Sci. 1979 Jun;18(6):642-5
(Latest) J:184697 Zhao J, et al., Loss of Msx2 Function Down-Regulates the FoxE3 Expression and Results in Anterior Segment Dysgenesis Resembling Peters Anomaly. Am J Pathol. 2012 Jun;180(6):2230-9
All references(59)

Other accession IDs

MGD-MRK-9263, MGI:1890502, MGI:95261