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Foxe3 Gene Detail
Summary
  • Symbol
    Foxe3
  • Name
    forkhead box E3
  • Synonyms
    FREAC8, rct
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353569
    NCBI Gene: 30923
  • Gene Overview
    MyGene.info: FOXE3
Location & Maps
more
  • Sequence Map
    Chr4:114925147-114926013 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      867 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FOXE3, forkhead box E3
  • Vertebrate Orthologs
    5
  • Human Ortholog
    FOXE3, forkhead box E3
    Orthology source: HGNC
  • Synonyms
    FKHL12, FREAC8
  • Links
    NCBI Gene ID: 2301
    neXtProt AC: NX_Q13461

  • Chr Location
    1p32; chr1:47416072-47418052 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Foxe3 mouse models; 2 with human FOXE3 associations

Human Disease Mouse Models
       Anterior Segment Mesenchymal Dysgenesis; ASMD   OMIM: 107250 View 1 model
       Peters Anomaly   OMIM: 604229 View 1 model
       Aphakia, Congenital Primary   OMIM: 610256
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 4 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    2 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    2
  • Targeted
    3
  • Genomic Mutations
    4 involving Foxe3
  • Incidental Mutations
Homozygotes for a spontaneous mutation exhibit microphthalmia, fusion of the lens and cornea, and other lens abnormalities. Homozygotes for a null mutation display microphthalmia, fusion of the lens and cornea, other corneal and lens abnormalities, and may fail to open their eyes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008588 VEGA Gene Model | MGI Sequence Detail 867 C57BL/6J ±  kb
transcript OTTMUST00000019473 VEGA | MGI Sequence Detail 867 Not Applicable  
polypeptide OTTMUSP00000008935 VEGA | MGI Sequence Detail 288 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    19 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007620 forkhead box protein E3
  • InterPro Domains
    IPR001766 Fork head domain
    IPR018122 Fork head domain conserved site1
    IPR030456 Fork head domain conserved site 2
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 8
    Genomic 2
    cDNA 3
    Primer pair 2
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-9263, MGI:1890502, MGI:95261
References
more
  • Summaries
    All 71
    Developmental Gene Expression 43
    Diseases 3
    Gene Ontology 12
    Phenotypes 19
  • Earliest
    J:6131 Sanyal S, et al., Dysgenetic lens (dyl)--a new gene in the mouse. Invest Ophthalmol Vis Sci. 1979 Jun;18(6):642-5
  • Latest
    J:225905 Dash S, et al., Deficiency of the RNA binding protein caprin2 causes lens defects and features of peters anomaly. Dev Dyn. 2015 Oct;244(10):1313-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory