About   Help   FAQ
Foxe3 Gene Detail
Summary
  • Symbol
    Foxe3
  • Name
    forkhead box E3
  • Synonyms
    FREAC8, rct
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353569
    NCBI Gene: 30923
  • Gene Overview
    MyGene.info: FOXE3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:114925147-114926013 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      867 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 52.73 cM, cytoband C7
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    FOXE3, forkhead box E3
  • Vertebrate Orthologs
    5
  • Human Ortholog
    FOXE3, forkhead box E3
    Orthology source: HGNC
  • Synonyms
    AAT11, ASGD2, CTRCT34, FKHL12, FREAC8
  • Links
    NCBI Gene ID: 2301
    neXtProt AC: NX_Q13461
    UniProt: Q13461

  • Chr Location
    1p33; chr1:47416072-47418052 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Foxe3 mouse models; 4 with human FOXE3 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 4 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    2 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous or null mutation display microphthalmia, fusion of the lens and cornea, and other corneal and lens abnormalities. Null mice have reduced smooth muscle cell density in the ascending aorta and show aortic remodeling and rupture of the aorta after TAC.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000008588 VEGA Gene Model | MGI Sequence Detail 867 C57BL/6J ±  kb
    transcript OTTMUST00000019473 VEGA | MGI Sequence Detail 867 Not Applicable  
    polypeptide OTTMUSP00000008935 VEGA | MGI Sequence Detail 288 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      19 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 2
      cDNA 5
      Primer pair 3
      Other 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-9263, MGI:1890502, MGI:95261
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 49
      Diseases 2
      Gene Ontology 11
      Phenotypes 20
    • Earliest
      J:6131 Sanyal S, et al., Dysgenetic lens (dyl)--a new gene in the mouse. Invest Ophthalmol Vis Sci. 1979 Jun;18(6):642-5
    • Latest
      J:251150 Aoki H, et al., Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells. PLoS One. 2016;11(9):e0163042

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory