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Foxe3
Gene Detail
Symbol

Name
ID
Foxe3
forkhead box E3
MGI:1353569
Synonyms
FREAC8, rct
Feature Type
protein coding gene
Genetic Map
Chromosome 4
52.73 cM, cytoband C7
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr4:114925147-114926013 bp, - strand
From VEGA annotation of GRCm38

  867 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32145  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken

Gene Tree: Foxe3

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a spontaneous mutation exhibit microphthalmia, fusion of the lens and cornea, and other lens abnormalities. Homozygotes for a null mutation display microphthalmia, fusion of the lens and cornea, other corneal and lens abnormalities, and may fail to open their eyes.
 
Human Diseases Modeled Using Mouse Foxe3 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Foxe3 interacts with 2 markers (Mir99a, Mir99b)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process camera-type eye development, cell development, ...
Component nucleus, transcription factor complex
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (103)    Tissues (96)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 101
cDNA source data(3)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(7) Genomic(2) cDNA(3) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000008588 (Evidence)
Ensembl Gene ModelENSMUSG00000044518 (Evidence)
Entrez Gene30923 (Evidence)
UniGene377122
DoTSDT.91439242
Consensus CDS ProjectCCDS18483.1
International Mouse Knockout Project StatusFoxe3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008588 VEGA Gene Model | MGI Sequence Detail 867 C57BL/6J ±  kb
transcript OTTMUST00000019473 VEGA | MGI Sequence Detail 867 Not Applicable 
polypeptide OTTMUSP00000008935 VEGA | MGI Sequence Detail 288 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007620 forkhead box protein E3
References
(Earliest) J:6131 Sanyal S, et al., Dysgenetic lens (dyl)--a new gene in the mouse. Invest Ophthalmol Vis Sci. 1979 Jun;18(6):642-5
(Latest) J:208421 Klimova L, et al., Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development. 2014 Mar;141(6):1292-302
All references(64)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-9263, MGI:1890502, MGI:95261

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory