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Cngb3 Gene Detail
Summary
  • Symbol
    Cngb3
  • Name
    cyclic nucleotide gated channel beta 3
  • Synonyms
    CCNC2, CNG6, Cngbeta2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353562
    NCBI Gene: 30952
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:19280850-19510623 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      229774 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 7.42 cM, cytoband A3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CNGB3, cyclic nucleotide gated channel beta 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CNGB3, cyclic nucleotide gated channel beta 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACHM1
  • Links
    NCBI Gene ID: 54714
    neXtProt AC: NX_Q9NQW8
    UniProt: Q9NQW8

  • Chr Location
    8q21.3; chr8:86573608-86743675 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Cngb3 mouse models; 2 with human CNGB3 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit cone degeneration and decreased photopic response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000004614 VEGA Gene Model | MGI Sequence Detail 229774 C57BL/6J ±  kb
    transcript OTTMUST00000010430 VEGA | MGI Sequence Detail 4708 Not Applicable  
    polypeptide OTTMUSP00000004949 VEGA | MGI Sequence Detail 694 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      926 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 2
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:60247 Gerstner A, et al., Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. J Neurosci. 2000 Feb 15;20(4):1324-32
    • Latest
      J:250132 Ma H, et al., Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration. FASEB J. 2017 Aug;31(8):3425-3438

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory