Cngb3
Gene Detail

Symbol Name ID

Cngb3 cyclic nucleotide gated channel beta 3 MGI:1353562

Synonyms

CCNC2, CNG6, Cngbeta2

Feature Type

protein coding gene

Genetic Map

Chromosome 4

7.42 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:19280850-19510623 bp, + strand From VEGA annotation of GRCm38   229774 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Cngb3 ± 2 cM)

Protein SuperFamily: cyclic nucleotide-gated cation channel, beta subunit
Gene Tree: Cngb3

Human ortholog

CNGB3 cyclic nucleotide gated channel beta 3 NCBI Gene ID 54714
Human Synonyms: ACHM1
Human Chr8:87586163-87755903 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human CNGB3 (2)

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele exhibit cone degeneration and decreased photopic response.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cation transport, cyclic nucleotide metabolic process, ...
Component	integral to membrane, membrane, ...
Function	cGMP binding, intracellular cGMP activated cation channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (1)    Images (2)
Theiler Stages: 28

Assay Type	Results
RNA in situ	2

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(8)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000004614 (Evidence)
Ensembl Gene Model	ENSMUSG00000056494 (Evidence)
Entrez Gene	30952 (Evidence)
UniGene	445778
DFCI	TC1590629
DoTS	DT.101348301, DT.91335298
NIA Mouse Gene Index	U004105
Consensus CDS Project	CCDS17990.1
International Mouse Knockout Project Status	Cngb3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004614	VEGA Gene Model | MGI Sequence Detail	229774	C57BL/6J
transcript	OTTMUST00000010430	VEGA | MGI Sequence Detail	4708	Not Applicable
polypeptide	OTTMUSP00000004949	VEGA | MGI Sequence Detail	694	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(761 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018488	Cyclic nucleotide-binding, conserved site
InterPro	IPR000595	Cyclic nucleotide-binding domain
InterPro	IPR018490	Cyclic nucleotide-binding-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR014710	RmlC-like jelly roll fold
Protein Ontology	PR:000000697	cyclic nucleotide-gated cation channel beta-3

References

(Earliest) J:60247 Gerstner A, et al., Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. J Neurosci. 2000 Feb 15;20(4):1324-32
(Latest) J:185617 Thapa A, et al., Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency. J Biol Chem. 2012 May 25;287(22):18018-29
All references(33)