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Cngb3 Gene Detail
Summary
  • Symbol
    Cngb3
  • Name
    cyclic nucleotide gated channel beta 3
  • Synonyms
    CCNC2, CNG6, Cngbeta2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353562
    NCBI Gene: 30952
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:19280850-19510623 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 7.42 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    926 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353562
protein coding gene Chr4:19280850-19510623 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028079
protein coding gene Chr4:16289937-16529869 (+)
A/J MGP_AJ_G0028037
protein coding gene Chr4:15831477-16071961 (+)
AKR/J MGP_AKRJ_G0028002
protein coding gene Chr4:16175138-16418733 (+)
BALB/cJ MGP_BALBcJ_G0028048
protein coding gene Chr4:15800409-16043638 (+)
C3H/HeJ MGP_C3HHeJ_G0027778
protein coding gene Chr4:16286312-16526580 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028491
protein coding gene Chr4:16951249-17193576 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025833
protein coding gene Chr4:14668493-14868200 (+)
CAST/EiJ MGP_CASTEiJ_G0027233
protein coding gene Chr4:16080067-16338534 (+)
CBA/J MGP_CBAJ_G0027751
protein coding gene Chr4:17428807-17685311 (+)
DBA/2J MGP_DBA2J_G0027894
protein coding gene Chr4:15623365-15880052 (+)
FVB/NJ MGP_FVBNJ_G0027860
protein coding gene Chr4:15376020-15606153 (+)
LP/J MGP_LPJ_G0028003
protein coding gene Chr4:16329968-16567901 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027893
protein coding gene Chr4:18404078-18722216 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028550
protein coding gene Chr4:16074614-16311791 (+)
PWK/PhJ MGP_PWKPhJ_G0026953
protein coding gene Chr4:15546725-15773942 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026782
protein coding gene Chr4:15943443-16183332 (+)
WSB/EiJ MGP_WSBEiJ_G0027310
protein coding gene Chr4:16139555-16373556 (+)



Homology
more
  • Human Ortholog
    CNGB3, cyclic nucleotide gated channel subunit beta 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNGB3, cyclic nucleotide gated channel subunit beta 3
  • Synonyms
    ACHM1
  • Links
    NCBI Gene ID: 54714
    neXtProt AC: NX_Q9NQW8
    UniProt: Q9NQW8

  • Chr Location
    8q21.3; chr8:86553977-86743675 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Cngb3 mouse models; 2 with human CNGB3 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit cone degeneration and decreased photopic response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30952 NCBI Gene Model | MGI Sequence Detail 229774 C57BL/6J ±  kb
    transcript NM_013927 RefSeq | MGI Sequence Detail 4708 C57BL/6  
    polypeptide Q9JJZ9 UniProt | EBI | MGI Sequence Detail 694 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:60247 Gerstner A, et al., Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. J Neurosci. 2000 Feb 15;20(4):1324-32
    • Latest
      J:316915 Yamada R, et al., MAB21L1 modulates gene expression and DNA metabolic processes in the lens placode. Dis Model Mech. 2021 Dec 1;14(12):dmm049251

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory