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Cngb3
Gene Detail
Symbol

Name
ID
Cngb3
cyclic nucleotide gated channel beta 3
MGI:1353562
Synonyms
CCNC2, CNG6, Cngbeta2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
7.42 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:19280850-19510623 bp, + strand
From VEGA annotation of GRCm38

  229774 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40908  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CNGB3
Protein SuperFamily: cyclic nucleotide-gated cation channel, beta subunit
Gene Tree: Cngb3

Human
homologs
CNGB3, cyclic nucleotide gated channel beta 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 54714
neXtProt AC: NX_Q9NQW8

Human Synonyms: ACHM1

Human Chr (Location): 8q21.3; chr8:86573843-86743675 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CNGB3

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit cone degeneration and decreased photopic response.
 
Interactions
Cngb3 interacts with 324 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (1)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000004614 (Evidence)
Ensembl Gene Model ENSMUSG00000056494 (Evidence)
Entrez Gene 30952 (Evidence)
UniGene 445778
DFCI TC1590629
DoTS DT.101348301, DT.91335298
NIA Mouse Gene Index U004105
Consensus CDS Project CCDS17990.1
International Mouse Phenotyping Consortium Status Cngb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004614 VEGA Gene Model | MGI Sequence Detail 229774 C57BL/6J ±  kb
transcript OTTMUST00000010430 VEGA | MGI Sequence Detail 4708 Not Applicable 
polypeptide OTTMUSP00000004949 VEGA | MGI Sequence Detail 694 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(945 from dbSNP Build 137)    SNPs within 2kb including multiple locations(951)
Protein-related
information
ResourceIDDescription
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000697 cyclic nucleotide-gated cation channel beta-3
References
(Earliest) J:60247 Gerstner A, et al., Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. J Neurosci. 2000 Feb 15;20(4):1324-32
(Latest) J:207409 Ma H, et al., Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3602-7
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory