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Vapa Gene Detail
Summary
  • Symbol
    Vapa
  • Name
    vesicle-associated membrane protein, associated protein A
  • Synonyms
    synaptobrevin-associated protein of 33kDa, VAP33
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353561
    NCBI Gene: 30960
  • Gene Overview
    MyGene.info: VAPA
Location & Maps
more
  • Sequence Map
    Chr17:65580056-65613555 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33500 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 34.90 cM, cytoband E1.2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    VAPA, VAMP associated protein A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    VAPA, VAMP associated protein A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hVAP-33, VAP33, VAP-33, VAP-A
  • Links
    NCBI Gene ID: 9218
    neXtProt AC: NX_Q9P0L0

  • Chr Location
    18p11.22; chr18:9913958-9960021 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    20
  • Gene trapped
    18
  • Targeted
    2
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024091 Ensembl Gene Model | MGI Sequence Detail 33500 C57BL/6J ±  kb
transcript ENSMUST00000024897 Ensembl | MGI Sequence Detail 1640 Not Applicable  
polypeptide ENSMUSP00000024897 Ensembl | MGI Sequence Detail 249 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    97 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000017257 vesicle-associated membrane protein-associated protein A
  • PDB
  • InterPro Domains
    IPR000535 Major sperm protein (MSP) domain
    IPR008962 PapD-like
    IPR016763 Vesicle-associated membrane-protein-associated protein
    IPR030229 Vesicle-associated membrane protein-associated protein A
Molecular
Reagents
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  • All nucleic 9
    cDNA 9

    Microarray probesets 6
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:60136 Skehel PA, et al., Mouse VAP33 is associated with the endoplasmic reticulum and microtubules. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1101-6
  • Latest
    J:228212 Cinque L, et al., FGF signalling regulates bone growth through autophagy. Nature. 2015 Dec 10;528(7581):272-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory