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Vapa Gene Detail
Summary
  • Symbol
    Vapa
  • Name
    vesicle-associated membrane protein, associated protein A
  • Synonyms
    synaptobrevin-associated protein of 33kDa, VAP33
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353561
    NCBI Gene: 30960
  • Gene Overview
    MyGene.info: VAPA
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:65580056-65613555 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 34.90 cM, cytoband E1.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353561
protein coding gene Chr17:65580053-65613939 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023977
protein coding gene Chr17:67708332-67743061 (-)
A/J MGP_AJ_G0023935
protein coding gene Chr17:65692619-65726250 (-)
AKR/J MGP_AKRJ_G0023904
protein coding gene Chr17:66605224-66638738 (-)
BALB/cJ MGP_BALBcJ_G0023936
protein coding gene Chr17:65626496-65659959 (-)
C3H/HeJ MGP_C3HHeJ_G0023700
protein coding gene Chr17:67494795-67528328 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024382
protein coding gene Chr17:70339150-70374010 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021828
protein coding gene Chr17:61723252-61756195 (-)
CAST/EiJ MGP_CASTEiJ_G0023182
protein coding gene Chr17:67831040-67865459 (-)
CBA/J MGP_CBAJ_G0023676
protein coding gene Chr17:73085476-73118971 (-)
DBA/2J MGP_DBA2J_G0023804
protein coding gene Chr17:64437456-64470843 (-)
FVB/NJ MGP_FVBNJ_G0023770
protein coding gene Chr17:63926079-63959881 (-)
LP/J MGP_LPJ_G0023886
protein coding gene Chr17:68435575-68470617 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023798
protein coding gene Chr17:73192872-73226395 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024426
protein coding gene Chr17:67072981-67106497 (-)
PWK/PhJ MGP_PWKPhJ_G0022928
protein coding gene Chr17:63703351-63737525 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022739
protein coding gene Chr17:63741306-63776231 (-)
WSB/EiJ MGP_WSBEiJ_G0023248
protein coding gene Chr17:67769067-67804938 (-)



Homology
more
  • Human Ortholog
    VAPA, VAMP associated protein A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    VAPA, VAMP associated protein A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hVAP-33, VAP33, VAP-33, VAP-A
  • Links
    NCBI Gene ID: 9218
    neXtProt AC: NX_Q9P0L0
    UniProt: Q9P0L0

  • Chr Location
    18p11.22; chr18:9913958-9960021 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024091 Ensembl Gene Model | MGI Sequence Detail 33500 C57BL/6J ±  kb
transcript ENSMUST00000024897 Ensembl | MGI Sequence Detail 3369 Not Applicable  
polypeptide ENSMUSP00000024897 Ensembl | MGI Sequence Detail 249 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000017257 vesicle-associated membrane protein-associated protein A
  • PDB
  • InterPro Domains
    IPR013783 Immunoglobulin-like fold
    IPR000535 Major sperm protein (MSP) domain
    IPR008962 PapD-like superfamily
    IPR016763 Vesicle-associated membrane-protein-associated protein
    IPR030229 Vesicle-associated membrane protein-associated protein A
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 6
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:60136 Skehel PA, et al., Mouse VAP33 is associated with the endoplasmic reticulum and microtubules. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1101-6
  • Latest
    J:228212 Cinque L, et al., FGF signalling regulates bone growth through autophagy. Nature. 2015 Dec 10;528(7581):272-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory