About   Help   FAQ
Take the Alliance for Genomic Resources User Survey
Schip1 Gene Detail
Summary
  • Symbol
    Schip1
  • Name
    schwannomin interacting protein 1
  • Synonyms
    SCHIP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353557
    NCBI Gene: 30953
Location & Maps
more
  • Sequence Map
    Chr3:68064802-68626481 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      561680 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 31.44 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SCHIP1, schwannomin interacting protein 1
  • Vertebrate Orthologs
    4
  • Human Ortholog
    SCHIP1, schwannomin interacting protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SCHIP-1
  • Links
    NCBI Gene ID: 29970
    neXtProt AC: NX_Q9P0W5

  • Chr Location
    3q25.32-q25.33; chr3:159273247-159897366 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    15 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Schip1
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for a gene trapped allele exhibit postnatal lethality, skeletal and craniofacial defects and defective cell mirgration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    249
  • Tissues
    42
  • cDNA Data
    36
  • Literature Summary
    5
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043622 VEGA Gene Model | MGI Sequence Detail 561680 C57BL/6J ±  kb
transcript OTTMUST00000114566 VEGA | MGI Sequence Detail 2201 Not Applicable  
polypeptide OTTMUSP00000063936 VEGA | MGI Sequence Detail 484 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3794 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014514 schwannomin-interacting protein 1
Molecular
Reagents
less
  • All nucleic 38
    cDNA 37
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 25
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:60244 Goutebroze L, et al., Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins. Mol Cell Biol. 2000 Mar;20(5):1699-712
  • Latest
    J:221642 Klingler E, et al., The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development. Development. 2015 Jun 1;142(11):2026-36
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory