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Schip1 Gene Detail
Summary
  • Symbol
    Schip1
  • Name
    schwannomin interacting protein 1
  • Synonyms
    SCHIP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353557
    NCBI Gene: 30953
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:68064802-68626481 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 31.44 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3794 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353557
 protein coding gene Chr3:68064802-68626482 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027286
 protein coding gene Chr3:67245213-67850826 (+)
A/J MGP_AJ_G0027248
 protein coding gene Chr3:65257455-65837670 (+)
AKR/J MGP_AKRJ_G0027216
 protein coding gene Chr3:66663479-67237727 (+)
BALB/cJ MGP_BALBcJ_G0027259
 protein coding gene Chr3:65127677-65712781 (+)
C3H/HeJ MGP_C3HHeJ_G0027003
 protein coding gene Chr3:66909516-67507203 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027705
 protein coding gene Chr3:69757724-70363893 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025058
 protein coding gene Chr3:61554916-62110886 (+)
CAST/EiJ MGP_CASTEiJ_G0026450
 protein coding gene Chr3:66864161-67435450 (+)
CBA/J MGP_CBAJ_G0026978
 protein coding gene Chr3:71930622-72562954 (+)
DBA/2J MGP_DBA2J_G0027114
 protein coding gene Chr3:64772962-65338200 (+)
FVB/NJ MGP_FVBNJ_G0027082
 protein coding gene Chr3:63388345-63954177 (+)
LP/J MGP_LPJ_G0027222
 protein coding gene Chr3:68178457-68782539 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027101
 protein coding gene Chr3:76589619-77189523 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027763
 protein coding gene Chr3:66528440-67117108 (+)
PWK/PhJ MGP_PWKPhJ_G0026184
 protein coding gene Chr3:64495274-65064879 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026000
 protein coding gene Chr3:65665188-66237690 (+)
WSB/EiJ MGP_WSBEiJ_G0026528
 protein coding gene Chr3:66665266-67254108 (+)



Homology
more
  • Human Ortholog
    SCHIP1, schwannomin interacting protein 1
  • Vertebrate Orthologs
    4
  • Human Ortholog
    SCHIP1, schwannomin interacting protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SCHIP-1
  • Links
    NCBI Gene ID: 29970
    neXtProt AC: NX_P0DPB3
    UniProt: P0DPB3

  • Chr Location
    3q25.32-q25.33; chr3:159273247-159897366 (+)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    15 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit postnatal lethality, skeletal and craniofacial defects and defective cell mirgration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    249
  • Tissues
    42
  • cDNA Data
    38
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027777 Ensembl Gene Model | MGI Sequence Detail 561680 C57BL/6J ±  kb
    transcript ENSMUST00000029346 Ensembl | MGI Sequence Detail 2201 Not Applicable  
    polypeptide ENSMUSP00000029346 Ensembl | MGI Sequence Detail 484 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR039045 Schwannomin interacting protein 1
      IPR015649 Schwannomin interacting protein 1, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 39
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:60244 Goutebroze L, et al., Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins. Mol Cell Biol. 2000 Mar;20(5):1699-712
    • Latest
      J:240720 Martin PM, et al., Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier. J Biol Chem. 2017 Feb 10;292(6):2441-2456
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    06/04/2019
    MGI 6.14     		The Jackson Laboratory