Schip1 MGI Mouse Gene Detail - MGI:1353557 - schwannomin interacting protein 1

Schip1 Gene Detail

Symbol

Schip1
Name

schwannomin interacting protein 1
Synonyms

SCHIP-1

Feature Type

protein coding gene
IDs

MGI:1353557
NCBI Gene: 30953

Sequence Map

Chr3:68064802-68626481 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

561680 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 31.44 cM, cytoband E2
Mapping Data

2 experiments

Human Ortholog

SCHIP1, schwannomin interacting protein 1

Vertebrate Orthologs

4

Human Ortholog

SCHIP1, schwannomin interacting protein 1
Orthology source: HomoloGene, HGNC
Synonyms

SCHIP-1
Links

HGNC:15678

NCBI Gene ID: 29970

neXtProt AC: NX_Q9P0W5

UniProt: Q9P0W5
Chr Location

3q25.32-q25.33; chr3:159273247-159897366 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 130673
1 human;1 mouse;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SCHIP1
Gene Tree

Schip1

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References

1 with disease annotations

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
15 phenotypes from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Schip1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available

Mice homozygous for a gene trapped allele exhibit postnatal lethality, skeletal and craniofacial defects and defective cell mirgration.

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All GO Annotations

16
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

249
Tissues

42
cDNA Data

36
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase schip1

ZFIN schip1

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Schip1 interacts with 202 markers (Mir1b, Mir7-1, Mir10a, ...) View All

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All Sequences

64
RefSeq

10
UniProt

1
CCDS

CCDS50926.1, CCDS50927.1, CCDS50929.1, CCDS71249.1
UniGene

331064

			Length	Strain/Species	Flank
genomic	OTTMUSG00000043622	VEGA Gene Model \| MGI Sequence Detail	561680	C57BL/6J	± kb
transcript	OTTMUST00000114566	VEGA \| MGI Sequence Detail	2201	Not Applicable
polypeptide	OTTMUSP00000063936	VEGA \| MGI Sequence Detail	484	Not Applicable

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SNPs within 2kb

3794 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000014514 schwannomin-interacting protein 1

(term hierarchy)

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All nucleic 38

cDNA 37

Other 1

Microarray probesets 3

Summaries

All 30

Developmental Gene Expression 5

Diseases 1

Gene Ontology 4

Phenotypes 7
Earliest

J:60244 Goutebroze L, et al., Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins. Mol Cell Biol. 2000 Mar;20(5):1699-712
Latest

J:240720 Martin PM, et al., Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier. J Biol Chem. 2017 Feb 10;292(6):2441-2456

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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