Schip1 MGI Mouse Gene Detail - MGI:1353557 - schwannomin interacting protein 1

Symbol

Schip1
Name

schwannomin interacting protein 1
Synonyms

SCHIP-1

Feature Type

protein coding gene
IDs

MGI:1353557
NCBI Gene: 30953
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr3:68064802-68626481 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 31.44 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

3794 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353557	protein coding gene	Chr3:68064802-68626482 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027286	protein coding gene	Chr3:67245213-67850826 (+)
A/J	MGP_AJ_G0027248	protein coding gene	Chr3:65257455-65837670 (+)
AKR/J	MGP_AKRJ_G0027216	protein coding gene	Chr3:66663479-67237727 (+)
BALB/cJ	MGP_BALBcJ_G0027259	protein coding gene	Chr3:65127677-65712781 (+)
C3H/HeJ	MGP_C3HHeJ_G0027003	protein coding gene	Chr3:66909516-67507203 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027705	protein coding gene	Chr3:69757724-70363893 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025058	protein coding gene	Chr3:61554916-62110886 (+)
CAST/EiJ	MGP_CASTEiJ_G0026450	protein coding gene	Chr3:66864161-67435450 (+)
CBA/J	MGP_CBAJ_G0026978	protein coding gene	Chr3:71930622-72562954 (+)
DBA/2J	MGP_DBA2J_G0027114	protein coding gene	Chr3:64772962-65338200 (+)
FVB/NJ	MGP_FVBNJ_G0027082	protein coding gene	Chr3:63388345-63954177 (+)
LP/J	MGP_LPJ_G0027222	protein coding gene	Chr3:68178457-68782539 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027101	protein coding gene	Chr3:76589619-77189523 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027763	protein coding gene	Chr3:66528440-67117108 (+)
PWK/PhJ	MGP_PWKPhJ_G0026184	protein coding gene	Chr3:64495274-65064879 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026000	protein coding gene	Chr3:65665188-66237690 (+)
WSB/EiJ	MGP_WSBEiJ_G0026528	protein coding gene	Chr3:66665266-67254108 (+)

Human Ortholog

SCHIP1, schwannomin interacting protein 1

Vertebrate Orthologs

4

Human Ortholog

SCHIP1, schwannomin interacting protein 1
Orthology source: HomoloGene, HGNC
Synonyms

SCHIP-1
Links

HGNC:15678

NCBI Gene ID: 29970

neXtProt AC: NX_P0DPB3

UniProt: P0DPB3
Chr Location

3q25.32-q25.33; chr3:159273247-159897366 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 130673
1 human;1 mouse;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SCHIP1
Gene Tree

Schip1

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References

1 with disease annotations

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
15 phenotypes from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Schip1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit postnatal lethality, skeletal and craniofacial defects and defective cell mirgration.

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All GO Annotations

19
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

880
Tissues

42
cDNA Data

38
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase schip1

ZFIN schip1

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Schip1 interacts with 202 markers (Mir1b, Mir7-1, Mir10a, ...) View All

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All Sequences

69
RefSeq

10
UniProt

5
CCDS

CCDS50926.1, CCDS50927.1, CCDS50929.1, CCDS71249.1
UniGene

331064

Ensembl

ENSMUSG00000027777 (Evidence)
NCBI Gene

30953

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027777	Ensembl Gene Model \| MGI Sequence Detail	561680	C57BL/6J	± kb
transcript	ENSMUST00000029346	Ensembl \| MGI Sequence Detail	2201	Not Applicable
polypeptide	ENSMUSP00000029346	Ensembl \| MGI Sequence Detail	484	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014514 schwannomin-interacting protein 1

(term hierarchy)
InterPro Domains

IPR039045 Schwannomin interacting protein 1

IPR015649 Schwannomin interacting protein 1, C-terminal

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All nucleic 40

cDNA 39

Other 1

Microarray probesets 3

Summaries

All 36

Developmental Gene Expression 6

Diseases 1

Gene Ontology 5

Phenotypes 7
Earliest

J:60244 Goutebroze L, et al., Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins. Mol Cell Biol. 2000 Mar;20(5):1699-712
Latest

J:240720 Martin PM, et al., Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier. J Biol Chem. 2017 Feb 10;292(6):2441-2456

TSS for Schip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29453	Chr3:68064398-68064407 (+)	-399 bp
Tssr29455	Chr3:68468162-68468209 (+)	403,384 bp
Tssr29457	Chr3:68493245-68493270 (+)	428,456 bp
Tssr898	Chr3:68494203-68494232 (+)	429,416 bp
Tssr29458	Chr3:68494232-68494268 (+)	429,448 bp
Tssr29459	Chr3:68494283-68494295 (+)	429,487 bp
Tssr29462	Chr3:68572381-68572392 (+)	507,585 bp
Tssr29463	Chr3:68572394-68572420 (+)	507,605 bp
Tssr29464	Chr3:68572426-68572437 (+)	507,630 bp
Tssr29465	Chr3:68572464-68572475 (+)	507,668 bp
Tssr29466	Chr3:68572508-68572515 (+)	507,710 bp
Tssr29467	Chr3:68572535-68572540 (+)	507,736 bp
Tssr29468	Chr3:68584103-68584125 (+)	519,312 bp
Tssr899	Chr3:68584132-68584141 (+)	519,335 bp
Tssr29469	Chr3:68584154-68584181 (+)	519,366 bp
Tssr29470	Chr3:68584184-68584207 (+)	519,394 bp
Tssr29471	Chr3:68584212-68584292 (+)	519,450 bp
Tssr29472	Chr3:68584310-68584313 (+)	519,510 bp
Tssr29473	Chr3:68584336-68584343 (+)	519,538 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/23/2021 MGI 6.16