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Sspn Gene Detail
Summary
  • Symbol
    Sspn
  • Name
    sarcospan
  • Synonyms
    Krag
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353511
    NCBI Gene: 16651
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:145877367-145910949 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 77.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    534 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353511
protein coding gene Chr6:145860423-145910951 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031484
protein coding gene Chr6:150963927-151001685 (+)
A/J MGP_AJ_G0031459
protein coding gene Chr6:144980287-145014480 (+)
AKR/J MGP_AKRJ_G0031387
protein coding gene Chr6:149291086-149324122 (+)
BALB/cJ MGP_BALBcJ_G0031467
protein coding gene Chr6:144730345-144763880 (+)
C3H/HeJ MGP_C3HHeJ_G0031188
protein coding gene Chr6:149336658-149369704 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031928
protein coding gene Chr6:155018552-155053911 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029052
protein coding gene Chr6:143713171-143746871 (+)
CAST/EiJ MGP_CASTEiJ_G0030556
protein coding gene Chr6:148974372-149007527 (+)
CBA/J MGP_CBAJ_G0031148
protein coding gene Chr6:160902029-160936625 (+)
DBA/2J MGP_DBA2J_G0031304
protein coding gene Chr6:143769239-143802519 (+)
FVB/NJ MGP_FVBNJ_G0031256
protein coding gene Chr6:142500643-142534340 (+)
LP/J MGP_LPJ_G0031389
protein coding gene Chr6:151061379-151101286 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031296
protein coding gene Chr6:164673951-164707876 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031961
protein coding gene Chr6:149124738-149157798 (+)
PWK/PhJ MGP_PWKPhJ_G0030283
protein coding gene Chr6:142274888-142308354 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030107
protein coding gene Chr6:147281050-147314290 (+)
WSB/EiJ MGP_WSBEiJ_G0030649
protein coding gene Chr6:149739443-149773662 (+)



Homology
more
  • Human Ortholog
    SSPN, sarcospan
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SSPN, sarcospan
  • Synonyms
    DAGA5, KRAG, NSPN, SPN1, SPN2
  • Links
    NCBI Gene ID: 8082
    neXtProt AC: NX_Q14714
    UniProt: Q14714

  • Chr Location
    12p12.1; chr12:26121991-26299290 (+)  GRCh38

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal muscle histology and physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030255 Ensembl Gene Model | MGI Sequence Detail 33583 C57BL/6J ±  kb
    transcript ENSMUST00000032383 Ensembl | MGI Sequence Detail 4431 Not Applicable  
    polypeptide ENSMUSP00000032383 Ensembl | MGI Sequence Detail 216 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 2
      cDNA 42
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16701, MGI:99905
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:12009 George DL, et al., Amplified DNA in Y1 mouse adrenal tumor cells: isolation of cDNAs complementary to an amplified c-Ki-ras gene and localization of homologous sequences to mouse chromosome 6. Nucleic Acids Res. 1984 Mar 26;12(6):2731-43
    • Latest
      J:340159 McCourt JL, et al., Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways. Skelet Muscle. 2023 Jan 6;13(1):1

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory