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Gene Detail
Rho guanine nucleotide exchange factor (GEF) 1
Synonyms Lbcl2, Lsc
Feature Type protein coding gene
Genetic Map
Chromosome 7
13.52 cM
Detailed Genetic Map ± 1 cM

Mapping data(1)
Sequence Map
Chr7:24902912-24926592 bp, + strand
From VEGA annotation of GRCm38

  23681 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:3454  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 2 dog; 1 western clawed frog

Protein SuperFamily: Rho guanine nucleotide exchange factor 1
Gene Tree: Arhgef1

Human Homolog ARHGEF1, Rho guanine nucleotide exchange factor (GEF) 1
NCBI Gene ID 9138
neXtProt AC  NX_Q92888
Human Synonyms  GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5
Human Chr (Location)  19q13.13; chr19:41883173-41907452 (+)  GRCh38
alleles, and
All mutations/alleles(23) : Gene trapped(18) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Homozygous mutation of this gene results in impaired humeral immunity, reduced numbers of marginal zone B (MZB) cells, decreased basal T cell proliferation, and reduced basal motility of lymphocytes but enhanced migration of MZB cells after serum activation.
Arhgef1 interacts with 83 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
All GO classifications: (12 annotations)
Process negative regulation of cell death, regulation of Rho protein signal transduction, ...
Component cytoplasm, membrane, ...
Function GTPase activator activity, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)   
Theiler Stages: 22, 24
Assay TypeResults
RNA in situ 2
cDNA source data(149)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(151) Genomic(1) cDNA(150)
Microarray probesets(4)
Other database
VEGA Gene ModelOTTMUSG00000029276 (Evidence)
Ensembl Gene ModelENSMUSG00000040940 (Evidence)
Entrez Gene16801 (Evidence)
DFCITC1573435, TC1601471, TC1621084, TC1671383, TC1694409, TC1726059, TC1748846, TC1775199
DoTSDT.101254386, DT.101322612, DT.101327302, DT.101379215, DT.101710762, DT.486450, DT.97334038, DT.97357378, DT.97385598
NIA Mouse Gene IndexU007812
Consensus CDS ProjectCCDS52140.1, CCDS52141.1, CCDS52142.1
International Mouse Knockout Project StatusArhgef1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029276 VEGA Gene Model | MGI Sequence Detail 23681 C57BL/6J ±  kb
transcript OTTMUST00000072538 VEGA | MGI Sequence Detail 3375 Not Applicable 
polypeptide OTTMUSP00000037378 VEGA | MGI Sequence Detail 979 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(15) UniProt(6)
Polymorphisms SNPs within 2kb(57 from dbSNP Build 137)
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR015212 Regulator of G protein signalling-like fold
InterPro IPR016137 Regulator of G protein signalling superfamily
InterPro IPR015721 Rho GTP exchange factor
Protein Ontology PR:000004245 rho guanine nucleotide exchange factor 1
References (Earliest) J:34523 Whitehead IP, et al., Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors. J Biol Chem. 1996 Aug 2;271(31):18643-50
(Latest) J:174313 Green JA, et al., The sphingosine 1-phosphate receptor S1P maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol. 2011;12(7):672-80
All references(54)
accession IDs
MGD-MRK-37468, MGI:108425

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory