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Arhgef1 Gene Detail
Summary
  • Symbol
    Arhgef1
  • Name
    Rho guanine nucleotide exchange factor 1
  • Synonyms
    Lbcl2, Lsc
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353510
    NCBI Gene: 16801
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24602337-24626019 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353510
 protein coding gene Chr7:24601762-24626019 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031848
 protein coding gene Chr7:23312990-23337704 (+)
A/J MGP_AJ_G0031827
 protein coding gene Chr7:22740898-22764996 (+)
AKR/J MGP_AKRJ_G0031756
 protein coding gene Chr7:23273521-23295001 (+)
BALB/cJ MGP_BALBcJ_G0031835
 protein coding gene Chr7:22945504-22967682 (+)
C3H/HeJ MGP_C3HHeJ_G0031553
 protein coding gene Chr7:23687237-23709729 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032296
 protein coding gene Chr7:24087094-24124486 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029351
 protein coding gene Chr7:24173612-24193915 (+)
CAST/EiJ MGP_CASTEiJ_G0030893
 protein coding gene Chr7:17165471-17186771 (+)
CBA/J MGP_CBAJ_G0031518
 protein coding gene Chr7:24974946-24999770 (+)
DBA/2J MGP_DBA2J_G0031672
 protein coding gene Chr7:22645955-22667625 (+)
FVB/NJ MGP_FVBNJ_G0031625
 protein coding gene Chr7:22624846-22648361 (+)
LP/J MGP_LPJ_G0031751
 protein coding gene Chr7:23625533-23647989 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031662
 protein coding gene Chr7:24710324-24733999 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032328
 protein coding gene Chr7:22971128-22992036 (+)
PWK/PhJ MGP_PWKPhJ_G0030617
 protein coding gene Chr7:17573751-17595718 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030448
 protein coding gene Chr7:14284524-14305659 (+)
WSB/EiJ MGP_WSBEiJ_G0030997
 protein coding gene Chr7:23134284-23156214 (+)



Homology
more
  • Human Ortholog
    ARHGEF1, Rho guanine nucleotide exchange factor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF1, Rho guanine nucleotide exchange factor 1
  • Synonyms
    GEF1, IMD62, LBCL2, LSC, P115-RHOGEF, SUB1.5
  • Links
    NCBI Gene ID: 9138
    neXtProt AC: NX_Q92888
    UniProt: Q92888

  • Chr Location
    19q13.2; chr19:41883173-41930150 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ARHGEF1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 5 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired humeral immunity, reduced numbers of marginal zone B (MZB) cells, decreased basal T cell proliferation, and reduced basal motility of lymphocytes but enhanced migration of MZB cells after serum activation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    22
  • cDNA Data
    150
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040940 Ensembl Gene Model | MGI Sequence Detail 23683 C57BL/6J ±  kb
    transcript ENSMUST00000098683 Ensembl | MGI Sequence Detail 3375 Not Applicable  
    polypeptide ENSMUSP00000096280 Ensembl | MGI Sequence Detail 979 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 152
      Genomic 1
      cDNA 151

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37468, MGI:108425
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 28
    • Earliest
      J:34523 Whitehead IP, et al., Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors. J Biol Chem. 1996 Aug 2;271(31):18643-50
    • Latest
      J:324874 Liu D, et al., CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells. Science. 2022 Feb 11;375(6581):eabi5965
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory