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Arhgef1 Gene Detail
Summary
  • Symbol
    Arhgef1
  • Name
    Rho guanine nucleotide exchange factor (GEF) 1
  • Synonyms
    Lbcl2, Lsc
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353510
    NCBI Gene: 16801
  • Gene Overview
    MyGene.info: ARHGEF1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:24902912-24926594 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23683 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.52 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ARHGEF1, Rho guanine nucleotide exchange factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ARHGEF1, Rho guanine nucleotide exchange factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5
  • Links
    NCBI Gene ID: 9138
    neXtProt AC: NX_Q92888
    UniProt: Q92888

  • Chr Location
    19q13.2; chr19:41883200-41907454 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 5 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired humeral immunity, reduced numbers of marginal zone B (MZB) cells, decreased basal T cell proliferation, and reduced basal motility of lymphocytes but enhanced migration of MZB cells after serum activation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000029276 VEGA Gene Model | MGI Sequence Detail 23683 C57BL/6J ±  kb
    transcript OTTMUST00000072538 VEGA | MGI Sequence Detail 3375 Not Applicable  
    polypeptide OTTMUSP00000037378 VEGA | MGI Sequence Detail 979 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      57 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 152
      Genomic 1
      cDNA 151

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37468, MGI:108425
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:34523 Whitehead IP, et al., Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors. J Biol Chem. 1996 Aug 2;271(31):18643-50
    • Latest
      J:241446 Xiang X, et al., Arhgef1 is expressed in cortical neural progenitor cells and regulates neurite outgrowth of newly differentiated neurons. Neurosci Lett. 2017 Jan 18;638:27-34

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory