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Arhgef1
Gene Detail
Symbol

Name
ID
Arhgef1
Rho guanine nucleotide exchange factor (GEF) 1
MGI:1353510
Synonyms
Lbcl2, Lsc
Feature Type
protein coding gene
Genetic Map
Chromosome 7
13.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:24902912-24926592 bp, + strand
From VEGA annotation of GRCm38

  23681 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3454  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 2 dog; 1 western clawed frog

HCOP human homology predictions: ARHGEF1
Protein SuperFamily: Rho guanine nucleotide exchange factor 1
Gene Tree: Arhgef1

Human
homologs
ARHGEF1, Rho guanine nucleotide exchange factor (GEF) 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9138
neXtProt AC: NX_Q92888

Human Synonyms: GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5

Human Chr (Location): 19q13.13; chr19:41883173-41907454 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(18) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in impaired humeral immunity, reduced numbers of marginal zone B (MZB) cells, decreased basal T cell proliferation, and reduced basal motility of lymphocytes but enhanced migration of MZB cells after serum activation.
 
Interactions
Arhgef1 interacts with 83 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(149)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase arhgef1 ; ZFIN arhgef1a, arhgef1b    NEW 
Molecular
reagents
All nucleic(151) Genomic(1) cDNA(150)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000029276 (Evidence)
Ensembl Gene Model ENSMUSG00000040940 (Evidence)
Entrez Gene 16801 (Evidence)
UniGene 3181
DFCI TC1726059, TC1601471, TC1573435, TC1694409, TC1748846, TC1775199, TC1621084, TC1671383
DoTS DT.97385598, DT.97334038, DT.101710762, DT.97357378, DT.101327302, DT.486450, DT.101379215, DT.101322612, DT.101254386
NIA Mouse Gene Index U007812
Consensus CDS Project CCDS52140.1, CCDS52141.1, CCDS52142.1
International Mouse Phenotyping Consortium Status Arhgef1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029276 VEGA Gene Model | MGI Sequence Detail 23681 C57BL/6J ±  kb
transcript OTTMUST00000072538 VEGA | MGI Sequence Detail 3375 Not Applicable 
polypeptide OTTMUSP00000037378 VEGA | MGI Sequence Detail 979 Not Applicable 

For the selected sequences
All sequences(110) RefSeq(15) UniProt(6)
Polymorphisms
SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR015212 Regulator of G protein signalling-like fold
InterPro IPR016137 Regulator of G protein signalling superfamily
InterPro IPR015721 Rho GTP exchange factor
Protein Ontology PR:000004245 rho guanine nucleotide exchange factor 1
References
(Earliest) J:34523 Whitehead IP, et al., Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors. J Biol Chem. 1996 Aug 2;271(31):18643-50
(Latest) J:217491 Muppidi JR, et al., Loss of signalling via Galpha13 in germinal centre B-cell-derived lymphoma. Nature. 2014 Dec 11;516(7530):254-8
All references(53)
Other
accession IDs
MGD-MRK-37468, MGI:108425

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory