Baz1b
Gene Detail

Symbol Name ID

Baz1b bromodomain adjacent to zinc finger domain, 1B MGI:1353499

Synonyms

Wbscr9, WSTF

Feature Type

protein coding gene

Genetic Map

Chromosome 5

75.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr5:135187264-135246129 bp, + strand From VEGA annotation of GRCm38   58866 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22651  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Baz1b

Human homologs

Human Homolog		BAZ1B, bromodomain adjacent to zinc finger domain, 1B
NCBI Gene ID		9031
neXtProt AC		NX_Q9UIG0
Human Synonyms		WBSCR10, WBSCR9, WSTF
Human Chr (Location)		7q11.23; chr7:72854728-72936615 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(28) : Targeted(4) Gene trapped(23) Chemically induced(1)
 

Mice homozygous for a null allele exhibit postnatal lethality by P2, small size at birth, impaired double strand DNA repair, and heart defects. Mice heterozygous for a null allele exhibit hypercalcemia and heart defects. Mice homozygous for an ENU mutation exhibit craniofacial and skeletal defects.

 
Human Diseases Modeled Using Mouse Baz1b (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	ATP-dependent chromatin remodeling, chromatin assembly or disassembly, ...
Component	centromeric heterochromatin, condensed chromosome, ...
Function	ATP binding, chromatin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (212)    Tissues (188)    Images (19)
Theiler Stages: 2, 3, 4, 5, 10, 17, 18, 19, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	185
Northern blot	12
RT-PCR	15

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(5) cDNA(18) Primer pair(3)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000017117 (Evidence)
Ensembl Gene Model	ENSMUSG00000002748 (Evidence)
Entrez Gene	22385 (Evidence)
DFCI	TC1577249, TC1598179
DoTS	DT.110649704, DT.60102924
NIA Mouse Gene Index	U006282
EC	2.7.10.2
Consensus CDS Project	CCDS19736.1
International Mouse Knockout Project Status	Baz1b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017117	VEGA Gene Model | MGI Sequence Detail	58866	C57BL/6J
transcript	OTTMUST00000041455	VEGA | MGI Sequence Detail	6492	Not Applicable
polypeptide	OTTMUSP00000018605	VEGA | MGI Sequence Detail	1479	Not Applicable

All sequences(40) RefSeq(2) UniProt(1)

Polymorphisms

PCR(1) : SNPs(105 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001487	Bromodomain
InterPro	IPR018359	Bromodomain, conserved site
InterPro	IPR018500	DDT domain, subgroup
InterPro	IPR018501	DDT domain superfamily
InterPro	IPR013136	WSTF/Acf1/Cbp146
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR019787	Zinc finger, PHD-finger
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR019786	Zinc finger, PHD-type, conserved site
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
Protein Ontology	PR:000004658	bromodomain adjacent to zinc finger domain protein 1B

References

(Earliest) J:51602 Peoples RJ, et al., Identification of the WBSCR9 gene, encoding a novel transcriptional regulator, in the Williams-Beuren syndrome deletion at 7q11.23. Cytogenet Cell Genet. 1998;82(3-4):238-46
(Latest) J:186535 Herriges JC, et al., Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
All references(58)

Other accession IDs

MGI:1329032, MGI:2141344