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Baz1b Gene Detail
Summary
  • Symbol
    Baz1b
  • Name
    bromodomain adjacent to zinc finger domain, 1B
  • Synonyms
    Wbscr9, WSTF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353499
    NCBI Gene: 22385
  • Gene Overview
    MyGene.info: BAZ1B
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135187323-135246131 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 75.05 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353499
protein coding gene Chr5:135187264-135246131 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030177
protein coding gene Chr5:139690221-139753114 (+)
A/J MGP_AJ_G0030145
protein coding gene Chr5:133715655-133777652 (+)
AKR/J MGP_AKRJ_G0030078
protein coding gene Chr5:138060864-138124014 (+)
BALB/cJ MGP_BALBcJ_G0030155
protein coding gene Chr5:135072621-135132768 (+)
C3H/HeJ MGP_C3HHeJ_G0029871
protein coding gene Chr5:138622998-138684005 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030608
protein coding gene Chr5:144919142-144981721 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027831
protein coding gene Chr5:128013024-128078180 (+)
CAST/EiJ MGP_CASTEiJ_G0029280
protein coding gene Chr5:138039392-138103953 (+)
CBA/J MGP_CBAJ_G0029841
protein coding gene Chr5:150591565-150659166 (+)
DBA/2J MGP_DBA2J_G0029992
protein coding gene Chr5:133616610-133675610 (+)
FVB/NJ MGP_FVBNJ_G0029947
protein coding gene Chr5:132751306-132809546 (+)
LP/J MGP_LPJ_G0030080
protein coding gene Chr5:140135770-140197638 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029979
protein coding gene Chr5:153602472-153665609 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030648
protein coding gene Chr5:137807932-137870461 (+)
PWK/PhJ MGP_PWKPhJ_G0028995
protein coding gene Chr5:132658913-132719975 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028830
protein coding gene Chr5:135372517-135437979 (+)
WSB/EiJ MGP_WSBEiJ_G0029354
protein coding gene Chr5:138558280-138617495 (+)



Homology
more
  • Human Ortholog
    BAZ1B, bromodomain adjacent to zinc finger domain 1B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BAZ1B, bromodomain adjacent to zinc finger domain 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    WBSCR10, WBSCR9, WSTF
  • Links
    NCBI Gene ID: 9031
    neXtProt AC: NX_Q9UIG0
    UniProt: Q9UIG0

  • Chr Location
    7q11.23; chr7:73440398-73522298 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 22651
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BAZ1B
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Baz1b mouse models

Human Disease Mouse Models
      
IDs
View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal lethality by P2, small size at birth, impaired double strand DNA repair, and heart defects. Mice heterozygous for a null allele exhibit hypercalcemia and heart defects. Mice homozygous for an ENU mutation exhibit craniofacial and skeletal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22385 NCBI Gene Model | MGI Sequence Detail 58809 C57BL/6J ±  kb
    transcript NM_011714 RefSeq | MGI Sequence Detail 6446 C57BL/6  
    polypeptide Q9Z277 UniProt | EBI | MGI Sequence Detail 1479 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 148
      Genomic 5
      cDNA 140
      Primer pair 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1329032, MGI:2141344
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 12
      Diseases 4
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:51602 Peoples RJ, et al., Identification of the WBSCR9 gene, encoding a novel transcriptional regulator, in the Williams-Beuren syndrome deletion at 7q11.23. Cytogenet Cell Genet. 1998;82(3-4):238-46
    • Latest
      J:231744 Sun H, et al., BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli. J Neurosci. 2016 Apr 6;36(14):3954-61

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory