About   Help   FAQ
Slc25a4 Gene Detail
Summary
  • Symbol
    Slc25a4
  • Name
    solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
  • Synonyms
    adenine nucleotide translocase-1, Ant1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353495
    NCBI Gene: 11739
  • Gene Overview
    MyGene.info: SLC25A4
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:46207339-46211009 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 26.22 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353495
protein coding gene Chr8:46206797-46211284 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033586
protein coding gene Chr8:45302685-45307172 (-)
A/J MGP_AJ_G0033568
protein coding gene Chr8:43541852-43546339 (-)
AKR/J MGP_AKRJ_G0033493
protein coding gene Chr8:44826605-44831092 (-)
BALB/cJ MGP_BALBcJ_G0033565
protein coding gene Chr8:43726965-43731452 (-)
C3H/HeJ MGP_C3HHeJ_G0033274
protein coding gene Chr8:45362973-45367460 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034081
protein coding gene Chr8:47005541-47010028 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031030
protein coding gene Chr8:39815228-39819867 (-)
CAST/EiJ MGP_CASTEiJ_G0032600
protein coding gene Chr8:44802718-44807031 (-)
CBA/J MGP_CBAJ_G0033253
protein coding gene Chr8:48910377-48914864 (-)
DBA/2J MGP_DBA2J_G0033406
protein coding gene Chr8:43355506-43359993 (-)
FVB/NJ MGP_FVBNJ_G0033347
protein coding gene Chr8:42847310-42851797 (-)
LP/J MGP_LPJ_G0033494
protein coding gene Chr8:45306589-45311076 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033392
protein coding gene Chr8:48976531-48981018 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034099
protein coding gene Chr8:44990894-44995381 (-)
PWK/PhJ MGP_PWKPhJ_G0032308
protein coding gene Chr8:42881208-42885724 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032144
protein coding gene Chr8:44147838-44152336 (-)
WSB/EiJ MGP_WSBEiJ_G0032716
protein coding gene Chr8:45246605-45251090 (-)



Homology
more
  • Human Ortholog
    SLC25A4, solute carrier family 25 member 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC25A4, solute carrier family 25 member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAC1, ANT, ANT1, ANT 1, MTDPS12, MTDPS12A, PEO2, PEO3, PEOA2, T1
  • Links
    NCBI Gene ID: 291
    neXtProt AC: NX_P12235
    UniProt: P12235

  • Chr Location
    4q35.1; chr4:185143263-185150384 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human SLC25A4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a defect in mitochondrial energy metabolism and develop mitochondrial myopathy and hypertrophic cardiomyopathy, metabolic acidosis, and a severe exercise intolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11739 NCBI Gene Model | MGI Sequence Detail 3671 C57BL/6J ±  kb
    transcript NM_007450 RefSeq | MGI Sequence Detail 1332 C57BL/6  
    polypeptide P48962 UniProt | EBI | MGI Sequence Detail 298 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 536
      Genomic 2
      cDNA 527
      Primer pair 6
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16246, MGI:2142690, MGI:99472
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 15
    • Earliest
      J:41737 Cozens AL, et al., DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase. J Mol Biol. 1989 20;206(2):261-80
    • Latest
      J:241649 Morrow RM, et al., Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity. Proc Natl Acad Sci U S A. 2017 Mar 07;114(10):2705-2710

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory