Slc25a4
Gene Detail

Symbol Name ID

Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 MGI:1353495

Synonyms

adenine nucleotide translocase-1, Ant1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

26.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr8:46206797-46211284 bp, - strand From VEGA annotation of GRCm38   4488 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36058  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc25a4

Human homologs

Human Homolog		SLC25A4, solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
NCBI Gene ID		291
neXtProt AC		NX_P12235
Human Synonyms		AAC1, ANT, ANT1, PEO2, PEO3, T1
Human Chr (Location)		4q35; chr4:186064417-186071538 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SLC25A4

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous null mice exhibit a defect in mitochondrial energy metabolism and develop mitochondrial myopathy and hypertrophic cardiomyopathy, metabolic acidosis, and a severe exercise intolerance.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	ADP transport, apoptotic mitochondrial changes, ...
Component	integral to membrane, membrane, ...
Function	ATP:ADP antiporter activity, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23

Assay Type	Results
RNA in situ	1

cDNA source data(514)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(524) Genomic(2) cDNA(515) Primer pair(6) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000016487 (Evidence)
Ensembl Gene Model	ENSMUSG00000031633 (Evidence)
Entrez Gene	11739 (Evidence)
UniGene	16228
DFCI	TC1573777, TC1596336, TC1655221
DoTS	DT.101167992, DT.101250935, DT.101738489, DT.102545603, DT.537407, DT.97390088
NIA Mouse Gene Index	U029786
Consensus CDS Project	CCDS40333.1
International Mouse Knockout Project Status	Slc25a4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016487	VEGA Gene Model | MGI Sequence Detail	4488	C57BL/6J
transcript	OTTMUST00000039783	VEGA | MGI Sequence Detail	1925	Not Applicable
polypeptide	OTTMUSP00000017747	VEGA | MGI Sequence Detail	298	Not Applicable

All sequences(40) RefSeq(3) UniProt(2)

Polymorphisms

All PCR and RFLP(5) : PCR(3) RFLP(2) SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002113	Adenine nucleotide translocator 1
InterPro	IPR023395	Mitochondrial carrier domain
InterPro	IPR002067	Mitochondrial carrier protein
InterPro	IPR018108	Mitochondrial substrate/solute carrier
Protein Ontology	PR:000015032	ADP/ATP translocase 1

References

(Earliest) J:41737 Cozens AL, et al., DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase. J Mol Biol. 1989 20;206(2):261-80
(Latest) J:183237 Loers G, et al., The interaction between cell adhesion molecule L1, matrix metalloproteinase 14, and adenine nucleotide translocator at the plasma membrane regulates L1-mediated neurite outgrowth of murine cerebellar neurons. J Neurosci. 2012 Mar 14;32(11):3917-30
All references(60)

Other accession IDs

MGD-MRK-16246, MGI:2142690, MGI:99472