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Slc25a4
Gene Detail
 Symbol
Name
ID
Slc25a4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
MGI:1353495
Synonyms adenine nucleotide translocase-1, Ant1
Feature Type protein coding gene
Genetic Map
Chromosome 8
26.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr8:46206797-46211284 bp, - strand
From VEGA annotation of GRCm38

  4488 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36058  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Slc25a4

Human
homologs
Human Homolog SLC25A4, solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
NCBI Gene ID 291
neXtProt AC  NX_P12235
Human Synonyms  1, AAC1, ANT, ANT1, ANT 1, MTDPS12, PEO2, PEO3, T1
Human Chr (Location)  4q35; chr4:185143263-185150384 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human SLC25A4
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Homozygous null mice exhibit a defect in mitochondrial energy metabolism and develop mitochondrial myopathy and hypertrophic cardiomyopathy, metabolic acidosis, and a severe exercise intolerance.
 
Interactions
Slc25a4 interacts with 113 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process ADP transport, apoptotic mitochondrial changes, ...
Component integral component of membrane, membrane, ...
Function ATP:ADP antiporter activity, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23
Assay TypeResults
RNA in situ 1
cDNA source data(525)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(535) Genomic(2) cDNA(526) Primer pair(6) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016487 (Evidence)
Ensembl Gene ModelENSMUSG00000031633 (Evidence)
Entrez Gene11739 (Evidence)
UniGene16228
DFCITC1573777, TC1596336, TC1655221
DoTSDT.101167992, DT.101250935, DT.101738489, DT.102545603, DT.537407, DT.97390088
NIA Mouse Gene IndexU029786
Consensus CDS ProjectCCDS40333.1
International Mouse Knockout Project StatusSlc25a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016487 VEGA Gene Model | MGI Sequence Detail 4488 C57BL/6J ±  kb
transcript OTTMUST00000039783 VEGA | MGI Sequence Detail 1925 Not Applicable 
polypeptide OTTMUSP00000017747 VEGA | MGI Sequence Detail 298 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(3) UniProt(2)
Polymorphisms All PCR and RFLP(5) : PCR(3) RFLP(2) SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002113 Adenine nucleotide translocator 1
InterPro IPR023395 Mitochondrial carrier domain
InterPro IPR002067 Mitochondrial carrier protein
InterPro IPR018108 Mitochondrial substrate/solute carrier
Protein Ontology PR:000015032 ADP/ATP translocase 1
References (Earliest) J:41737 Cozens AL, et al., DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase. J Mol Biol. 1989 20;206(2):261-80
(Latest) J:195325 Strauss KA, et al., Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3453-8
All references(62)
Other
accession IDs
MGD-MRK-16246, MGI:2142690, MGI:99472

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory