Slc22a4
Gene Detail

Symbol Name ID

Slc22a4 solute carrier family 22 (organic cation transporter), member 4 MGI:1353479

Synonyms

Octn1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

32.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:53983123-54028090 bp, - strand From VEGA annotation of GRCm38   44968 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:81701  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc22a4

Human homologs

Human Homolog		SLC22A4, solute carrier family 22 (organic cation/ergothioneine transporter), member 4
NCBI Gene ID		6583
neXtProt AC		NX_Q9H015
Human Synonyms		OCTN1
Human Chr (Location)		5q31.1; chr5:131630145-131679899 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC22A4

Alleles and phenotypes

All alleles(1) : Targeted(1)

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	carnitine metabolic process, carnitine transport, ...
Component	apical plasma membrane, integral to membrane, ...
Function	ATP binding, carnitine transmembrane transporter activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (337)    Tissues (135)    Images (75)
Theiler Stages: 10, 18, 22, 23, 25, 28

Assay Type	Results
RNA in situ	316
Western blot	7
RT-PCR	14

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(3) cDNA(21) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005654 (Evidence)
Ensembl Gene Model	ENSMUSG00000020334 (Evidence)
Entrez Gene	30805 (Evidence)
UniGene	274590
DFCI	TC1582427
DoTS	DT.101164461, DT.101338651, DT.528353
NIA Mouse Gene Index	U032773
Consensus CDS Project	CCDS24689.1
International Mouse Knockout Project Status	Slc22a4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005654	VEGA Gene Model | MGI Sequence Detail	44968	C57BL/6J
transcript	OTTMUST00000012580	VEGA | MGI Sequence Detail	2263	Not Applicable
polypeptide	OTTMUSP00000005826	VEGA | MGI Sequence Detail	553	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(411 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005828	General substrate transporter
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
InterPro	IPR004749	Organic cation transport protein
InterPro	IPR005829	Sugar transporter, conserved site
Protein Ontology	PR:000014991	solute carrier family 22 member 4

References

(Earliest) J:60187 Zhu Y, et al., Genomic interval engineering of mice identifies a novel modulator of triglyceride production. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1137-42
(Latest) J:185731 Cui JY, et al., RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development. Toxicol Sci. 2012 Jun;127(2):592-608
All references(35)