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Slc22a4
Gene Detail
Symbol

Name
ID
Slc22a4
solute carrier family 22 (organic cation transporter), member 4
MGI:1353479
Synonyms
Octn1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
32.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:53983123-54028090 bp, - strand
From VEGA annotation of GRCm38

  44968 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81701  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: SLC22A4
Gene Tree: Slc22a4

Human
homologs
SLC22A4, solute carrier family 22 (organic cation/zwitterion transporter), member 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6583
neXtProt AC: NX_Q9H015

Human Synonyms: OCTN1

Human Chr (Location): 5q31.1; chr5:132294384-132344206 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC22A4

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Genomic Mutations involving Slc22a4 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit complete loss of ergothioneine with reduced absorption and increased excretion and increased susceptibility of small intestine to inflammation following ischemia and reperfusion.
 
Interactions
Slc22a4 interacts with 121 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (337)    Tissues (135)    Images (75)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 316
Western blot 7
RT-PCR 14
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc22a4 ; ZFIN slc22a4    NEW 
Molecular
reagents
All nucleic(26) Genomic(3) cDNA(20) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005654 (Evidence)
Ensembl Gene Model ENSMUSG00000020334 (Evidence)
Entrez Gene 30805 (Evidence)
UniGene 274590
DFCI TC1582427
DoTS DT.101164461, DT.528353, DT.101338651
NIA Mouse Gene Index U032773
Consensus CDS Project CCDS24689.1
International Mouse Phenotyping Consortium Status Slc22a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005654 VEGA Gene Model | MGI Sequence Detail 44968 C57BL/6J ±  kb
transcript OTTMUST00000012580 VEGA | MGI Sequence Detail 2263 Not Applicable 
polypeptide OTTMUSP00000005826 VEGA | MGI Sequence Detail 553 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(456 from dbSNP Build 137)    SNPs within 2kb including multiple locations(462)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR004749 Organic cation transport protein
InterPro IPR005829 Sugar transporter, conserved site
Protein Ontology PR:000014991 solute carrier family 22 member 4
References
(Earliest) J:60187 Zhu Y, et al., Genomic interval engineering of mice identifies a novel modulator of triglyceride production. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1137-42
(Latest) J:206909 Shitara Y, et al., Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria. Toxicol Sci. 2013 Mar;132(1):32-42
All references(38)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory