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Slc39a1
Gene Detail
 Symbol
Name
ID
Slc39a1
solute carrier family 39 (zinc transporter), member 1
MGI:1353474
Synonyms zip1, Zirtl
Feature Type protein coding gene
Genetic Map
Chromosome 3
39.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:90248172-90253612 bp, + strand
From VEGA annotation of GRCm38

  5441 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40906  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Slc39a1

Human
homologs
Human Homolog SLC39A1, solute carrier family 39 (zinc transporter), member 1
NCBI Gene ID 27173
neXtProt AC  NX_Q9NY26
Human Synonyms  ZIP1, ZIRTL
Human Chr (Location)  1q21; chr1:153959099-153968184 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(13) Targeted(2)
 
On a zinc-adequate diet, homozygous null mutant mice exhibit normal fertility and normal embryonic and postnatal development. E14 embryos of dams fed a zinc-deficient diet from day E8 have <3.3-fold the incidence of abnormalities seen in wild-type embryos of zinc-deprived wild-type mothers.
 
Interactions
Slc39a1 interacts with 185 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process divalent inorganic cation transport, ion transport, ...
Component integral component of membrane, membrane, ...
Function metal ion transmembrane transporter activity, receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (298)    Tissues (119)    Images (53)
Theiler Stages: 1, 21, 22, 23, 28
Assay TypeResults
RNA in situ 271
In situ reporter (knock in) 15
Northern blot 6
Western blot 6
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(1) cDNA(40) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000029569 (Evidence)
Ensembl Gene ModelENSMUSG00000052310 (Evidence)
Entrez Gene30791 (Evidence)
UniGene294709
DoTSDT.101346161, DT.491828
NIA Mouse Gene IndexU003488, U118581
Consensus CDS ProjectCCDS17525.1
International Mouse Knockout Project StatusSlc39a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029569 VEGA Gene Model | MGI Sequence Detail 5441 C57BL/6J ±  kb
transcript OTTMUST00000073332 VEGA | MGI Sequence Detail 2364 Not Applicable 
polypeptide OTTMUSP00000037932 VEGA | MGI Sequence Detail 324 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003689 Zinc/iron permease
Protein Ontology PR:000015123 zinc transporter ZIP1
References (Earliest) J:57132 Lioumi M, et al., Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex. Genomics. 1999 Dec 1;62(2):272-80
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory