Slc39a1
Gene Detail

Symbol Name ID

Slc39a1 solute carrier family 39 (zinc transporter), member 1 MGI:1353474

Synonyms

zip1, Zirtl

Feature Type

protein coding gene

Genetic Map

Chromosome 3

39.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:90248172-90253612 bp, + strand From VEGA annotation of GRCm38   5441 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40906  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Slc39a1

Human homologs

Human Homolog		SLC39A1, solute carrier family 39 (zinc transporter), member 1
NCBI Gene ID		27173
neXtProt AC		NX_Q9NY26
Human Synonyms		ZIP1, ZIRTL
Human Chr (Location)		1q21; chr1:153959099-153968184 (-)  GRCh38

Alleles and phenotypes

All alleles(15) : Gene trapped(13) Targeted(2)
 

On a zinc-adequate diet, homozygous null mutant mice exhibit normal fertility and normal embryonic and postnatal development. E14 embryos of dams fed a zinc-deficient diet from day E8 have <3.3-fold the incidence of abnormalities seen in wild-type embryos of zinc-deprived wild-type mothers.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	divalent inorganic cation transport, ion transport, ...
Component	integral component of membrane, membrane, ...
Function	metal ion transmembrane transporter activity, receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)

Data Summary: Results (298)    Tissues (119)    Images (53)
Theiler Stages: 1, 21, 22, 23, 28

Assay Type	Results
RNA in situ	271
In situ reporter (knock in)	15
Northern blot	6
Western blot	6

cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) Genomic(1) cDNA(40) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000029569 (Evidence)
Ensembl Gene Model	ENSMUSG00000052310 (Evidence)
Entrez Gene	30791 (Evidence)
UniGene	294709
DoTS	DT.101346161, DT.491828
NIA Mouse Gene Index	U003488, U118581
Consensus CDS Project	CCDS17525.1
International Mouse Knockout Project Status	Slc39a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029569	VEGA Gene Model | MGI Sequence Detail	5441	C57BL/6J
transcript	OTTMUST00000073332	VEGA | MGI Sequence Detail	2364	Not Applicable
polypeptide	OTTMUSP00000037932	VEGA | MGI Sequence Detail	324	Not Applicable

All sequences(29) RefSeq(4) UniProt(4)

Polymorphisms

SNPs within 2kb(2 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR003689	Zinc/iron permease
Protein Ontology	PR:000015123	zinc transporter ZIP1

References

(Earliest) J:57132 Lioumi M, et al., Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex. Genomics. 1999 Dec 1;62(2):272-80
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(41)