About   Help   FAQ
Take the Alliance for Genomic Resources User Survey
Slc39a1 Gene Detail
Summary
  • Symbol
    Slc39a1
  • Name
    solute carrier family 39 (zinc transporter), member 1
  • Synonyms
    zip1, Zirtl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353474
    NCBI Gene: 30791
  • Gene Overview
    MyGene.info: SLC39A1
Location & Maps
more
  • Sequence Map
    Chr3:90248172-90253612 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      5441 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.21 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC39A1, solute carrier family 39 member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SLC39A1, solute carrier family 39 member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ZIP1, ZIRTL
  • Links
    NCBI Gene ID: 27173
    neXtProt AC: NX_Q9NY26

  • Chr Location
    1q21; chr1:153959099-153968184 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Gene trapped
    13
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Slc39a1
On a zinc-adequate diet, homozygous null mutant mice exhibit normal fertility and normal embryonic and postnatal development. E14 embryos of dams fed a zinc-deficient diet from day E8 have <3.3-fold the incidence of abnormalities seen in wild-type embryos of zinc-deprived wild-type mothers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    304
  • Tissues
    120
  • cDNA Data
    39
  • Literature Summary
    8
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029569 VEGA Gene Model | MGI Sequence Detail 5441 C57BL/6J ±  kb
transcript OTTMUST00000073332 VEGA | MGI Sequence Detail 2364 Not Applicable  
polypeptide OTTMUSP00000037932 VEGA | MGI Sequence Detail 324 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    2 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000015123 zinc transporter ZIP1
  • InterPro Domains
    IPR003689 Zinc/iron permease
Molecular
Reagents
less
  • All nucleic 44
    Genomic 1
    cDNA 40
    Primer pair 3

    Microarray probesets 4
References
more
  • Summaries
    All 39
    Developmental Gene Expression 8
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:57132 Lioumi M, et al., Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex. Genomics. 1999 Dec 1;62(2):272-80
  • Latest
    J:227247 Brommage R, et al., High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res. 2014;2:14034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory