Pdlim4 MGI Mouse Gene Detail - MGI:1353470

Symbol

Pdlim4
Name

PDZ and LIM domain 4
Synonyms

Ril

Feature Type

protein coding gene
IDs

MGI:1353470
NCBI Gene: 30794
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:53945754-53959814 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 32.13 cM
Mapping Data

2 experiments

SNPs within 2kb

404 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353470	protein coding gene	Chr11:53945754-53959840 (-)
129S1/SvImJ	ENSMUSG00200039027	protein coding gene	Chr11:50941840-50955927 (-)
A/J	ENSMUSG00195033515	protein coding gene	Chr11:50879159-50893247 (-)
AKR/J	ENSMUSG00220035761	protein coding gene	Chr11:51068047-51082135 (-)
BALB/cJ	ENSMUSG00180029276	protein coding gene	Chr11:50944250-50958339 (-)
C3H/HeJ	ENSMUSG00175032918	protein coding gene	Chr11:50910415-50924501 (-)
C57BL/6NJ	ENSMUSG00215021817	protein coding gene	Chr11:50733200-50747287 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016352	protein coding gene	Chr11:48982508-48996706 (-)
CAST/EiJ	ENSTCUG00005042199	protein coding gene	Chr11:50509232-50523408 (-)
CBA/J	ENSMUSG00210028384	protein coding gene	Chr11:50766291-50780375 (-)
DBA/2J	ENSMUSG00185027620	protein coding gene	Chr11:50983405-50997523 (-)
FVB/NJ	ENSMUSG00205020234	protein coding gene	Chr11:50808726-50822814 (-)
JF1/MsJ	ENSUMUG00000032153	protein coding gene	Chr11:51357119-51371242 (-)
LP/J	ENSMUSG00230047488	protein coding gene	Chr11:52159462-52173548 (-)
NOD/ShiLtJ	ENSMUSG00190034471	protein coding gene	Chr11:51034685-51048782 (-)
NZO/HlLtJ	ENSMUSG00225030416	protein coding gene	Chr11:54209875-54223998 (-)
PWK/PhJ	ENSLUMG00010026554	protein coding gene	Chr11:50805732-50819834 (-)
SPRET/EiJ	ENSMSPG00010016737	protein coding gene	Chr11:51486867-51500878 (-)
WSB/EiJ	ENSIUOG00005037883	protein coding gene	Chr11:50817740-50831907 (-)

Human Ortholog

PDLIM4, PDZ and LIM domain 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDLIM4, PDZ and LIM domain 4
Synonyms

RIL
Links

HGNC:16501

NCBI Gene ID: 8572

UniProt: P50479
Chr Location

5q31.1; chr5:132257644-132273454 (+) GRCh38

MGI Vertebrate Homology

Pdlim4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PDLIM4
Gene Tree

Pdlim4

Diseases

1 with human PDLIM4 associations

				Human Disease	Mouse Models
				osteoporosis IDs osteoporosis DOID:11476 EFO:0003882 ICD10CM:M81.0 ICD9CM:733.0 ICD9CM:733.00 MESH:D010024 NCI:C3298 OMIM:166710 UMLS_CUI:C0029456

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

4
Genomic Mutations

2 involving Pdlim4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

70
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

927
Tissues

118
cDNA Data

41
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PDLIM4

Xenbase pdlim4

ZFIN pdlim4

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All Sequences

50
RefSeq

12
UniProt

3
CCDS

CCDS24690.1

Ensembl

ENSMUSG00000020388 (Evidence)
NCBI Gene

30794

			Length	Strain/Species	Flank
genomic	30794	NCBI Gene Model \| MGI Sequence Detail	14061	C57BL/6J	± kb
transcript	NM_019417	RefSeq \| MGI Sequence Detail	1156	C57BL/6
polypeptide	P70271	UniProt \| EBI \| MGI Sequence Detail	330	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029668 PDZ and LIM domain protein 4

(term hierarchy)
InterPro Domains

IPR050604 PDZ and LIM domain-containing

IPR031847 PDZ and LIM domain protein 1-4/Zasp-like, middle domain

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR001781 Zinc finger, LIM-type

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All nucleic 44

Genomic 2

cDNA 41

Primer pair 1

Microarray probesets 4

Summaries

All 58

Developmental Gene Expression 15

Gene Ontology 8

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pdlim4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr107977	Chr11:53960039-53960082 (-)	-247 bp
Tssr107976	Chr11:53959776-53959843 (-)	4 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24