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Adamts8 Gene Detail
Summary
  • Symbol
    Adamts8
  • Name
    ADAM metallopeptidase with thrombospondin type 1 motif 8
  • Synonyms
    METH2, METH-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353468
    NCBI Gene: 30806
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:30853858-30875134 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 16.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353468
 protein coding gene Chr9:30853858-30875134 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034514
 protein coding gene Chr9:28583956-28608854 (+)
A/J MGP_AJ_G0034492
 protein coding gene Chr9:27900437-27921779 (+)
AKR/J MGP_AKRJ_G0034418
 protein coding gene Chr9:28461688-28483006 (+)
BALB/cJ MGP_BALBcJ_G0034483
 protein coding gene Chr9:27772669-27794087 (+)
C3H/HeJ MGP_C3HHeJ_G0034195
 protein coding gene Chr9:28822676-28844678 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035004
 protein coding gene Chr9:29576023-29597190 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031934
 protein coding gene Chr9:26727386-26748430 (+)
CAST/EiJ MGP_CASTEiJ_G0033518
 protein coding gene Chr9:28674146-28696192 (+)
CBA/J MGP_CBAJ_G0034169
 protein coding gene Chr9:30546824-30572168 (+)
DBA/2J MGP_DBA2J_G0034326
 protein coding gene Chr9:27911486-27932644 (+)
FVB/NJ MGP_FVBNJ_G0034269
 protein coding gene Chr9:27319314-27340741 (+)
LP/J MGP_LPJ_G0034412
 protein coding gene Chr9:28787221-28811770 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034313
 protein coding gene Chr9:32222373-32244959 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035024
 protein coding gene Chr9:28462213-28483371 (+)
PWK/PhJ MGP_PWKPhJ_G0033223
 protein coding gene Chr9:27844714-27866070 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033057
 protein coding gene Chr9:28552806-28573792 (+)
WSB/EiJ MGP_WSBEiJ_G0033633
 protein coding gene Chr9:28200421-28222391 (+)



Homology
more
  • Human Ortholog
    ADAMTS8, ADAM metallopeptidase with thrombospondin type 1 motif 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTS8, ADAM metallopeptidase with thrombospondin type 1 motif 8
  • Synonyms
    ADAM-TS8, METH2
  • Links
    NCBI Gene ID: 11095
    neXtProt AC: NX_Q9UP79
    UniProt: Q9UP79

  • Chr Location
    11q24.3; chr11:130404923-130428609 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    14
  • cDNA Data
    11
  • Literature Summary
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 30806 NCBI Gene Model | MGI Sequence Detail 21277 C57BL/6J ±  kb
transcript NM_013906 RefSeq | MGI Sequence Detail 4613 ZRU/MplStud  
polypeptide P57110 UniProt | EBI | MGI Sequence Detail 905 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 32
    Developmental Gene Expression 8
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:56487 Georgiadis KE, et al., ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. Genomics. 1999 Dec 1;62(2):312-5
  • Latest
    J:332240 Feng W, et al., Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages. Nat Commun. 2022 Dec 27;13(1):7960
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory