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Adamts8 Gene Detail
Summary
  • Symbol
    Adamts8
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8
  • Synonyms
    METH2, METH-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353468
    NCBI Gene: 30806
Location & Maps
more
  • Sequence Map
    Chr9:30942562-30963838 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21277 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ADAMTS8, ADAM metallopeptidase with thrombospondin type 1 motif 8
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ADAMTS8, ADAM metallopeptidase with thrombospondin type 1 motif 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADAM-TS8, METH2
  • Links
    NCBI Gene ID: 11095
    neXtProt AC: NX_Q9UP79

  • Chr Location
    11q25; chr11:130404923-130428644 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034192 VEGA Gene Model | MGI Sequence Detail 21277 C57BL/6J ±  kb
transcript OTTMUST00000086712 VEGA | MGI Sequence Detail 3631 Not Applicable  
polypeptide OTTMUSP00000046965 VEGA | MGI Sequence Detail 905 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    121 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 6
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:56487 Georgiadis KE, et al., ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. Genomics. 1999 Dec 1;62(2):312-5
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory