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Adamts8
Gene Detail
 Symbol
Name
ID
Adamts8
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8
MGI:1353468
Synonyms METH2, METH-2
Feature Type protein coding gene
Genetic Map
Chromosome 9
16.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:30942562-30963838 bp, + strand
From VEGA annotation of GRCm38

  21277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5108  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Adamts8

Human
homologs
Human Homolog ADAMTS8, ADAM metallopeptidase with thrombospondin type 1 motif, 8
NCBI Gene ID 11095
neXtProt AC  NX_Q9UP79
Human Synonyms  ADAM-TS8, METH2
Human Chr (Location)  11q25; chr11:130404923-130428952 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Adamts8 interacts with 335 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process proteolysis
Component extracellular matrix, extracellular region, ...
Function heparin binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (35)    Tissues (7)    Images (19)
Theiler Stages: 11, 23
Assay TypeResults
RNA in situ 34
RT-PCR 1
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000034192 (Evidence)
Ensembl Gene ModelENSMUSG00000031994 (Evidence)
Entrez Gene30806 (Evidence)
UniGene100582
DFCITC1585710, TC1723651
DoTSDT.40148902, DT.94269463, DT.97341318
EC3.4.24.-
Consensus CDS ProjectCCDS22946.1
International Mouse Knockout Project StatusAdamts8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034192 VEGA Gene Model | MGI Sequence Detail 21277 C57BL/6J ±  kb
transcript OTTMUST00000086712 VEGA | MGI Sequence Detail 3631 Not Applicable 
polypeptide OTTMUSP00000046965 VEGA | MGI Sequence Detail 905 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(121 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010294 ADAM-TS Spacer 1
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR013273 Peptidase M12B, ADAM-TS
InterPro IPR013277 Peptidase M12B, ADAM-TS8
InterPro IPR002870 Peptidase M12B, propeptide
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000003736 A disintegrin and metalloproteinase with thrombospondin motifs 8
References (Earliest) J:56487 Georgiadis KE, et al., ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. Genomics. 1999 Dec 1;62(2):312-5
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory