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Adamts8 Gene Detail
Summary
  • Symbol
    Adamts8
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8
  • Synonyms
    METH2, METH-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353468
    NCBI Gene: 30806
  • Gene Overview
    MyGene.info: ADAMTS8
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:30942562-30963838 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 16.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353468
protein coding gene Chr9:30942562-30963838 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034514
protein coding gene Chr9:28583956-28608854 (+)
A/J MGP_AJ_G0034492
protein coding gene Chr9:27900437-27921779 (+)
AKR/J MGP_AKRJ_G0034418
protein coding gene Chr9:28461688-28483006 (+)
BALB/cJ MGP_BALBcJ_G0034483
protein coding gene Chr9:27772669-27794087 (+)
C3H/HeJ MGP_C3HHeJ_G0034195
protein coding gene Chr9:28822676-28844678 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035004
protein coding gene Chr9:29576023-29597190 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031934
protein coding gene Chr9:26727386-26748430 (+)
CAST/EiJ MGP_CASTEiJ_G0033518
protein coding gene Chr9:28674146-28696192 (+)
CBA/J MGP_CBAJ_G0034169
protein coding gene Chr9:30546824-30572168 (+)
DBA/2J MGP_DBA2J_G0034326
protein coding gene Chr9:27911486-27932644 (+)
FVB/NJ MGP_FVBNJ_G0034269
protein coding gene Chr9:27319314-27340741 (+)
LP/J MGP_LPJ_G0034412
protein coding gene Chr9:28787221-28811770 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034313
protein coding gene Chr9:32222373-32244959 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035024
protein coding gene Chr9:28462213-28483371 (+)
PWK/PhJ MGP_PWKPhJ_G0033223
protein coding gene Chr9:27844714-27866070 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033057
protein coding gene Chr9:28552806-28573792 (+)
WSB/EiJ MGP_WSBEiJ_G0033633
protein coding gene Chr9:28200421-28222391 (+)



Homology
more
  • Human Ortholog
    ADAMTS8, ADAM metallopeptidase with thrombospondin type 1 motif 8
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ADAMTS8, ADAM metallopeptidase with thrombospondin type 1 motif 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADAM-TS8, METH2
  • Links
    NCBI Gene ID: 11095
    neXtProt AC: NX_Q9UP79
    UniProt: Q9UP79

  • Chr Location
    11q24.3; chr11:130404923-130428993 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 30806 NCBI Gene Model | MGI Sequence Detail 21277 C57BL/6J ±  kb
transcript NM_013906 RefSeq | MGI Sequence Detail 4613 C57BL/6  
polypeptide P57110 UniProt | EBI | MGI Sequence Detail 905 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 7
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:56487 Georgiadis KE, et al., ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. Genomics. 1999 Dec 1;62(2):312-5
  • Latest
    J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory