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Fkbp3 Gene Detail
Summary
  • Symbol
    Fkbp3
  • Name
    FK506 binding protein 3
  • Synonyms
    25kDa, FKBP25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353460
    NCBI Gene: 30795
  • Gene Overview
    MyGene.info: FKBP3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:65062432-65073938 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 27.21 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353460
protein coding gene Chr12:65062424-65074007 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019779
protein coding gene Chr12:64541791-64557581 (-)
A/J MGP_AJ_G0019738
protein coding gene Chr12:62160472-62172166 (-)
AKR/J MGP_AKRJ_G0019713
protein coding gene Chr12:64139830-64151357 (-)
BALB/cJ MGP_BALBcJ_G0019718
protein coding gene Chr12:62601888-62613474 (-)
C3H/HeJ MGP_C3HHeJ_G0019523
protein coding gene Chr12:64485935-64497425 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020170
protein coding gene Chr12:66579015-66595045 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017790
protein coding gene Chr12:59976842-59988212 (-)
CAST/EiJ MGP_CASTEiJ_G0019075
protein coding gene Chr12:59192640-59204152 (-)
CBA/J MGP_CBAJ_G0019492
protein coding gene Chr12:69005235-69016827 (-)
DBA/2J MGP_DBA2J_G0019608
protein coding gene Chr12:62088578-62100005 (-)
FVB/NJ MGP_FVBNJ_G0019596
protein coding gene Chr12:61115050-61126225 (-)
LP/J MGP_LPJ_G0019680
protein coding gene Chr12:64563170-64575833 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019634
protein coding gene Chr12:71872339-71883793 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020204
protein coding gene Chr12:63527185-63538638 (-)
PWK/PhJ MGP_PWKPhJ_G0018841
protein coding gene Chr12:56355213-56373639 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018635
protein coding gene Chr12:57850048-57861605 (-)
WSB/EiJ MGP_WSBEiJ_G0019126
protein coding gene Chr12:64058665-64070143 (-)



Homology
more
  • Human Ortholog
    FKBP3, FK506 binding protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FKBP3, FK506 binding protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKBP25, FKBP-25, FKBP-3, PPIase
  • Links
    NCBI Gene ID: 2287
    neXtProt AC: NX_Q00688
    UniProt: Q00688

  • Chr Location
    14q21.2; chr14:45115599-45134529 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 30795 NCBI Gene Model | MGI Sequence Detail 11507 C57BL/6J ±  kb
transcript NM_013902 RefSeq | MGI Sequence Detail 945 C57BL/6  
polypeptide Q62446 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 123
    cDNA 119
    Primer pair 3
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 46
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:62503 Murphy M, et al., Wild-type p53 negatively regulates the expression of a microtubule-associated protein. Genes Dev. 1996 Dec 1;10(23):2971-80
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory