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Aldh3a2 Gene Detail
Summary
  • Symbol
    Aldh3a2
  • Name
    aldehyde dehydrogenase family 3, subfamily A2
  • Synonyms
    Ahd3, Ahd-3, Ahd-3r, Ahd3-r, Aldh4, Aldh4-r, FALDH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353452
    NCBI Gene: 11671
Location & Maps
more
  • Sequence Map
    Chr11:61223417-61267464 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      44048 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    ALDH3A2, aldehyde dehydrogenase 3 family member A2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ALDH3A2, aldehyde dehydrogenase 3 family member A2
    Orthology source: HomoloGene
  • Synonyms
    ALDH10, FALDH, SLS
  • Links
    NCBI Gene ID: 224
    neXtProt AC: NX_P51648

  • Chr Location
    17p11.2; chr17:19648136-19677596 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ALDH3A2 associations

Human Disease Mouse Models
       Sjogren-Larsson Syndrome; SLS   OMIM: 270200
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Targeted
    8
  • Genomic Mutations
    3 involving Aldh3a2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005829 VEGA Gene Model | MGI Sequence Detail 44048 C57BL/6J ±  kb
transcript OTTMUST00000012932 VEGA | MGI Sequence Detail 2892 Not Applicable  
polypeptide OTTMUSP00000006017 VEGA | MGI Sequence Detail 532 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    426 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000003927 fatty aldehyde dehydrogenase
  • EC
  • InterPro Domains
    IPR016163 Aldehyde dehydrogenase, C-terminal
    IPR016160 Aldehyde dehydrogenase, cysteine active site
    IPR015590 Aldehyde dehydrogenase domain
    IPR029510 Aldehyde dehydrogenase, glutamic acid active site
    IPR012394 Aldehyde dehydrogenase NAD(P)-dependent
    IPR016162 Aldehyde dehydrogenase N-terminal domain
    IPR016161 Aldehyde/histidinol dehydrogenase
Molecular
Reagents
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  • All nucleic 117
    cDNA 115
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1207, MGD-MRK-1208, MGD-MRK-1214, MGD-MRK-1215, MGD-MRK-16379, MGD-MRK-16380, MGI:2144079, MGI:99597, MGI:99598
References
more
  • Summaries
    All 58
    Developmental Gene Expression 6
    Diseases 2
    Gene Ontology 9
    Phenotypes 21
  • Earliest
    J:6570 Timms GP, et al., Genetics of aldehyde dehydrogenase isozymes in the mouse: evidence for multiple loci and localization of Ahd-2 on chromosome 19. Genetics. 1981 Feb;97(2):327-36
  • Latest
    J:228662 Nishiyama M, et al., FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. Stem Cells. 2015 Nov;33(11):3327-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory