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Aldh3a2 Gene Detail
Summary
  • Symbol
    Aldh3a2
  • Name
    aldehyde dehydrogenase family 3, subfamily A2
  • Synonyms
    Ahd3, Ahd-3, Ahd-3r, Ahd3-r, Aldh4, Aldh4-r, FALDH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353452
    NCBI Gene: 11671
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:61223417-61267464 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      44048 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    ALDH3A2, aldehyde dehydrogenase 3 family member A2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ALDH3A2, aldehyde dehydrogenase 3 family member A2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALDH10, FALDH, SLS
  • Links
    NCBI Gene ID: 224
    neXtProt AC: NX_P51648
    UniProt: P51648

  • Chr Location
    17p11.2; chr17:19648136-19677596 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ALDH3A2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit impaired long-chain base metabolism, hyperproliferation of keratinocytes, widened intercellular spaces in the basal layer of the epidermis, and delayed barrier recovery after stratum corneum perturbation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005829 VEGA Gene Model | MGI Sequence Detail 44048 C57BL/6J ±  kb
    transcript OTTMUST00000012932 VEGA | MGI Sequence Detail 2892 Not Applicable  
    polypeptide OTTMUSP00000006017 VEGA | MGI Sequence Detail 532 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      426 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
    • InterPro Domains
      IPR016163 Aldehyde dehydrogenase, C-terminal
      IPR016160 Aldehyde dehydrogenase, cysteine active site
      IPR015590 Aldehyde dehydrogenase domain
      IPR029510 Aldehyde dehydrogenase, glutamic acid active site
      IPR012394 Aldehyde dehydrogenase NAD(P)-dependent
      IPR016162 Aldehyde dehydrogenase, N-terminal
      IPR016161 Aldehyde/histidinol dehydrogenase
    Molecular
    Reagents
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    • All nucleic 117
      cDNA 115
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1207, MGD-MRK-1208, MGD-MRK-1214, MGD-MRK-1215, MGD-MRK-16379, MGD-MRK-16380, MGI:2144079, MGI:99597, MGI:99598
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 8
      Phenotypes 22
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory