About   Help   FAQ
Eif2ak1 Gene Detail
Summary
  • Symbol
    Eif2ak1
  • Name
    eukaryotic translation initiation factor 2 alpha kinase 1
  • Synonyms
    Hri
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353448
    NCBI Gene: 15467
  • Gene Overview
    MyGene.info: EIF2AK1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:143817788-143904251 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      86464 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 82.67 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EIF2AK1, eukaryotic translation initiation factor 2 alpha kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF2AK1, eukaryotic translation initiation factor 2 alpha kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HCR, HRI
  • Links
    NCBI Gene ID: 27102
    neXtProt AC: NX_Q9BQI3
    UniProt: Q9BQI3

  • Chr Location
    7p22.1; chr7:6022247-6059229 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit enlarged heart size and abnormal red blood cell development, morphology, and physiology with macrocytic anemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000025503 VEGA Gene Model | MGI Sequence Detail 86464 C57BL/6J ±  kb
    transcript OTTMUST00000062772 VEGA | MGI Sequence Detail 4325 Not Applicable  
    polypeptide OTTMUSP00000031009 VEGA | MGI Sequence Detail 619 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      234 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1333789
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 12
    • Earliest
      J:51221 Berlanga JJ, et al., Characterization of the hemin-sensitive eukaryotic initiation factor 2alpha kinase from mouse nonerythroid cells. J Biol Chem. 1998 Nov 27;273(48):32340-6
    • Latest
      J:243727 Nguyen AT, et al., UBE2O remodels the proteome during terminal erythroid differentiation. Science. 2017 Aug 04;357(6350)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory