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Fbxw2 Gene Detail
Summary
  • Symbol
    Fbxw2
  • Name
    F-box and WD-40 domain protein 2
  • Synonyms
    FBW2, Fwd2, MD6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353435
    NCBI Gene: 30050
  • Gene Overview
    MyGene.info: FBXW2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:34804514-34826311 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.96 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353435
protein coding gene Chr2:34804364-34826311 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025642
protein coding gene Chr2:33413188-33434792 (-)
A/J MGP_AJ_G0025619
protein coding gene Chr2:31993014-32014798 (-)
AKR/J MGP_AKRJ_G0025589
protein coding gene Chr2:33124123-33145856 (-)
BALB/cJ MGP_BALBcJ_G0025616
protein coding gene Chr2:32103280-32125009 (-)
C3H/HeJ MGP_C3HHeJ_G0025376
protein coding gene Chr2:33014862-33037338 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026060
protein coding gene Chr2:34381987-34404512 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023469
protein coding gene Chr2:30691604-30714280 (-)
CAST/EiJ MGP_CASTEiJ_G0024838
protein coding gene Chr2:33010296-33033509 (-)
CBA/J MGP_CBAJ_G0025354
protein coding gene Chr2:35711733-35735279 (-)
DBA/2J MGP_DBA2J_G0025487
protein coding gene Chr2:31765272-31786789 (-)
FVB/NJ MGP_FVBNJ_G0025449
protein coding gene Chr2:31658230-31679785 (-)
LP/J MGP_LPJ_G0025573
protein coding gene Chr2:33330575-33353978 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025480
protein coding gene Chr2:35229530-35252264 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026118
protein coding gene Chr2:33012064-33035372 (-)
PWK/PhJ MGP_PWKPhJ_G0024586
protein coding gene Chr2:31679557-31703206 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024386
protein coding gene Chr2:33172175-33195365 (-)
WSB/EiJ MGP_WSBEiJ_G0024907
protein coding gene Chr2:33188788-33214258 (-)



Homology
more
  • Human Ortholog
    FBXW2, F-box and WD repeat domain containing 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FBXW2, F-box and WD repeat domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBW2, Fwd2, Md6
  • Links
    NCBI Gene ID: 26190
    neXtProt AC: NX_Q9UKT8
    UniProt: Q9UKT8

  • Chr Location
    9q33.2; chr9:120756976-120793471 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8131
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FBXW2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035949 Ensembl Gene Model | MGI Sequence Detail 21798 C57BL/6J ±  kb
transcript ENSMUST00000028220 Ensembl | MGI Sequence Detail 2030 Not Applicable  
polypeptide ENSMUSP00000028220 Ensembl | MGI Sequence Detail 454 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 10
References
more
  • Summaries
    All 33
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:53625 Duff K, et al., Secondary structure analysis identifies a putative mouse protein demonstrating similarity to the repeat units found in CDC4, the G protein beta subunits and related proteins. DNA Seq. 1992;3(4):213-20
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory