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Fbxw2 Gene Detail
Summary
  • Symbol
    Fbxw2
  • Name
    F-box and WD-40 domain protein 2
  • Synonyms
    FBW2, Fwd2, MD6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353435
    NCBI Gene: 30050
  • Gene Overview
    MyGene.info: FBXW2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:34804514-34826311 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21798 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.96 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FBXW2, F-box and WD repeat domain containing 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FBXW2, F-box and WD repeat domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBW2, Fwd2, Md6
  • Links
    NCBI Gene ID: 26190
    neXtProt AC: NX_Q9UKT8
    UniProt: Q9UKT8

  • Chr Location
    9q33.2; chr9:120756976-120793471 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8131
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FBXW2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012022 VEGA Gene Model | MGI Sequence Detail 21798 C57BL/6J ±  kb
transcript OTTMUST00000028539 VEGA | MGI Sequence Detail 2030 Not Applicable  
polypeptide OTTMUSP00000012913 VEGA | MGI Sequence Detail 454 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    62 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 10
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:53625 Duff K, et al., Secondary structure analysis identifies a putative mouse protein demonstrating similarity to the repeat units found in CDC4, the G protein beta subunits and related proteins. DNA Seq. 1992;3(4):213-20
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory