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Gulo Gene Detail
Summary
  • Symbol
    Gulo
  • Name
    gulonolactone (L-) oxidase
  • Synonyms
    L-gulono-gamma-lactone oxidase, MGC:29968, MGC:37793, MGC:37880, sfx
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353434
    NCBI Gene: 268756
  • Gene Overview
    MyGene.info: GULOP
Location & Maps
more
  • Sequence Map
    Chr14:65986787-66009210 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22424 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 34.36 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GULOP, gulonolactone (L-) oxidase, pseudogene
  • Vertebrate Orthologs
    6
  • Human Ortholog
    GULOP, gulonolactone (L-) oxidase, pseudogene
    Orthology source: HGNC
  • Synonyms
    GULO, SCURVY
  • Links
    NCBI Gene ID: 2989

  • Chr Location
    8p21.1; chr8:27577611-27589073 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GULOP associations

Human Disease Mouse Models
       Hypoascorbemia   OMIM: 240400
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 3 alleles in 4 genetic backgrounds
    4 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Spontaneous
    2
  • Targeted
    1
  • Genomic Mutations
    2 involving Gulo
  • Incidental Mutations
Homozygotes for spontaneous mutations exhibit impaired growth and mobility, decreased spleen and thymus weights, reduced serum calcium, phosphate, alkaline phosphatase, IGF1, and osteocalcin levels, and small, fragile and histologically abnormal bones.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034450 Ensembl Gene Model | MGI Sequence Detail 22424 C57BL/6J ±  kb
transcript ENSMUST00000059970 Ensembl | MGI Sequence Detail 2265 Not Applicable  
polypeptide ENSMUSP00000060912 Ensembl | MGI Sequence Detail 440 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    137 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008398 L-gulonolactone oxidase
  • EC
  • InterPro Domains
    IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
    IPR007173 D-arabinono-1,4-lactone oxidase
    IPR016166 FAD-binding, type 2
    IPR016167 FAD-binding, type 2, subdomain 1
    IPR006094 FAD linked oxidase, N-terminal
    IPR010031 L-gulonolactone/D-arabinono-1,4-lactone oxidase
    IPR006093 Oxygen oxidoreductase covalent FAD-binding site
    IPR030654 Sugar 1,4-lactone oxidase
Molecular
Reagents
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  • All nucleic 70
    cDNA 69
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGI:1890379, MGI:2145730, MGI:2679273
References
more
  • Summaries
    All 47
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 24
  • Earliest
    J:59931 Maeda N, et al., Aortic wall damage in mice unable to synthesize ascorbic acid. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):841-6
  • Latest
    J:211508 Kim JH, et al., Chronic vitamin C insufficiency aggravated thioacetamide-induced liver fibrosis in gulo-knockout mice. Free Radic Biol Med. 2014 Feb;67:81-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory