About   Help   FAQ
Gulo
Gene Detail
 Symbol
Name
ID
Gulo
gulonolactone (L-) oxidase
MGI:1353434
Synonyms L-gulono-gamma-lactone oxidase, MGC:29968, MGC:37793, MGC:37880, sfx
Feature Type protein coding gene
Genetic Map
Chromosome 14
34.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:65986787-66009210 bp, - strand
From NCBI annotation of GRCm38

  22424 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6566  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: L-gulonolactone/D-arabinono-1,4-lactone oxidase
Gene Tree: Gulo

Alleles
and
phenotypes
All alleles(3) : Spontaneous(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for spontaneous mutations exhibit impaired growth and mobility, decreased spleen and thymus weights, reduced serum calcium, phosphate, alkaline phosphatase, IGF1, and osteocalcin levels, and small, fragile and histologically abnormal bones.
 
Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process biosynthetic process, L-ascorbic acid biosynthetic process, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function catalytic activity, D-arabinono-1,4-lactone oxidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (120)    Tissues (97)    Images (28)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 120
cDNA source data(69)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(70) cDNA(69) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000034450 (Evidence)
Entrez Gene268756 (Evidence)
UniGene26207
DFCITC1578269
DoTSDT.101370812, DT.491451
NIA Mouse Gene IndexU035698
EC1.1.3.8
Consensus CDS ProjectCCDS36958.1
International Mouse Knockout Project StatusGulo
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 268756 NCBI Gene Model | MGI Sequence Detail 22424 C57BL/6J ±  kb
transcript NM_178747 RefSeq | MGI Sequence Detail 2265 C57BL/6 
polypeptide P58710 UniProt | EBI | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(5) UniProt(3)
Polymorphisms SNPs within 2kb(139 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
InterPro IPR007173 D-arabinono-1,4-lactone oxidase
InterPro IPR016166 FAD-binding, type 2
InterPro IPR016167 FAD-binding, type 2, subdomain 1
InterPro IPR006094 FAD linked oxidase, N-terminal
InterPro IPR010032 FAD-linked oxidoreductase
InterPro IPR023595 L-gulonolactone/D-arabinono-1,4-lactone oxidase
InterPro IPR006093 Oxygen oxidoreductase covalent FAD-binding site
InterPro IPR010031 Sugar 1,4-lactone oxidase
Protein Ontology PR:000008398 L-gulonolactone oxidase
Graphical View of Protein Domain Structure
References (Earliest) J:59931 Maeda N, et al., Aortic wall damage in mice unable to synthesize ascorbic acid. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):841-6
(Latest) J:205309 Kim H, et al., Vitamin C prevents stress-induced damage on the heart caused by the death of cardiomyocytes, through down-regulation of the excessive production of catecholamine, TNF-alpha, and ROS production in Gulo(-/-)Vit C-Insufficient mice. Free Radic Biol Med. 2013 Dec;65:573-83
All references(52)
Other
accession IDs
MGI:1890379, MGI:2145730, MGI:2679273

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory