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Dnajc12 Gene Detail
Summary
  • Symbol
    Dnajc12
  • Name
    DnaJ heat shock protein family (Hsp40) member C12
  • Synonyms
    J domain protein 1, Jdp1, mJDP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353428
    NCBI Gene: 30045
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:63218222-63244619 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.57 cM, cytoband B4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    756 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353428
 protein coding gene Chr10:63218222-63246355 (+)
129S1/SvImJ ENSMUSG00200028318
 protein coding gene Chr10:59891033-59919174 (+)
A/J ENSMUSG00195027055
 protein coding gene Chr10:60198464-60226597 (+)
AKR/J ENSMUSG00220037989
 protein coding gene Chr10:59891795-59919935 (+)
BALB/cJ ENSMUSG00180022796
 protein coding gene Chr10:60240818-60268955 (+)
C3H/HeJ ENSMUSG00175024281
 protein coding gene Chr10:60098189-60126326 (+)
C57BL/6NJ ENSMUSG00215025300
 protein coding gene Chr10:59838832-59866970 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015402
 protein coding gene Chr10:57864719-57880704 (+)
CAST/EiJ ENSTCUG00005027559
 protein coding gene Chr10:59888338-59910988 (+)
CBA/J ENSMUSG00210032360
 protein coding gene Chr10:59976510-60009280 (+)
DBA/2J ENSMUSG00185040883
 protein coding gene Chr10:60318125-60346260 (+)
FVB/NJ ENSMUSG00205033992
 protein coding gene Chr10:59992120-60020260 (+)
JF1/MsJ ENSUMUG00000020236
 protein coding gene Chr10:61559707-61582501 (+)
LP/J ENSMUSG00230015737
 protein coding gene Chr10:62123579-62146381 (+)
NOD/ShiLtJ ENSMUSG00190030481
 protein coding gene Chr10:60303778-60331915 (+)
NZO/HlLtJ ENSMUSG00225044254
 protein coding gene Chr10:66402001-66430134 (+)
PWK/PhJ ENSLUMG00010022243
 protein coding gene Chr10:59948376-59971297 (+)
SPRET/EiJ ENSMSPG00010021700
 protein coding gene Chr10:61482564-61507607 (+)
WSB/EiJ ENSIUOG00005041213
 protein coding gene Chr10:59882671-59910848 (+)



Homology
more
  • Human Ortholog
    DNAJC12, DnaJ heat shock protein family (Hsp40) member C12
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAJC12, DnaJ heat shock protein family (Hsp40) member C12
  • Synonyms
    HPANBH4, JDP1
  • Links
    NCBI Gene ID: 56521
    UniProt: Q9UKB3

  • Chr Location
    10q21.3; chr10:67796668-67838188 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display hypoactivity and reduced striatal dopamine and serotonin levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    628
  • Tissues
    9
  • cDNA Data
    44
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30045 NCBI Gene Model | MGI Sequence Detail 26398 C57BL/6J ±  kb
    transcript NM_013888 RefSeq | MGI Sequence Detail 1305 C57BL/6  
    polypeptide Q9R022 UniProt | EBI | MGI Sequence Detail 198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 45
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:376259 Deng IB, et al., Central biogenic amine deficiency with concomitant exploratory behavioral deficits in Dnajc12 knock-out mice. NPJ Parkinsons Dis. 2025 May 30;11(1):143
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory