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Opn4
Gene Detail
 Symbol
Name
ID
Opn4
opsin 4 (melanopsin)
MGI:1353425
Synonyms 1110007J02Rik
Feature Type protein coding gene
Genetic Map
Chromosome 14
20.83 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:34590618-34600142 bp, - strand
From NCBI annotation of GRCm38

  9525 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69152  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: animal opsin
Gene Tree: Opn4

Human
homologs
Human Homolog OPN4, opsin 4
NCBI Gene ID 94233
neXtProt AC  NX_Q9UHM6
Human Synonyms  MOP
Human Chr (Location)  10q22; chr10:86654557-86666460 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene results in absent intrinsic inner retinal photosensitivity, abnormal pupillary reflex, and abnormal circadian rhythms.
 
Interactions
Opn4 interacts with 123 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process detection of visible light, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function 11-cis retinal binding, G-protein coupled photoreceptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (17)    Tissues (7)   
Theiler Stages: 17, 19, 20, 21, 22, 23, 28
Assay TypeResults
RT-PCR 17
cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(5) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000021799 (Evidence)
Entrez Gene30044 (Evidence)
UniGene272060
DFCITC1591660, TC1613638
DoTSDT.40151610, DT.55202745
NIA Mouse Gene IndexU035415, U035416
Consensus CDS ProjectCCDS26943.1, CCDS49446.1
International Mouse Knockout Project StatusOpn4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 30044 NCBI Gene Model | MGI Sequence Detail 9525 C57BL/6J ±  kb
transcript NM_001128599 RefSeq | MGI Sequence Detail 2259 Not Specified 
polypeptide Q9QXZ9 UniProt | EBI | MGI Sequence Detail 521 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(130 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001760 Opsin
InterPro IPR027430 Visual pigments (opsins) retinal binding site
Protein Ontology PR:000001243 melanopsin
Graphical View of Protein Domain Structure
References (Earliest) J:59329 Provencio I, et al., A novel human opsin in the inner retina. J Neurosci. 2000 Jan 15;20(2):600-5
(Latest) J:211359 Buhr ED, et al., Local photic entrainment of the retinal circadian oscillator in the absence of rods, cones, and melanopsin. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8625-30
All references(94)
Other
accession IDs
MGI:2685379

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory