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Opn4 Gene Detail
Summary
  • Symbol
    Opn4
  • Name
    opsin 4 (melanopsin)
  • Synonyms
    1110007J02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353425
    NCBI Gene: 30044
  • Gene Overview
    MyGene.info: OPN4
Location & Maps
more
  • Sequence Map
    Chr14:34590618-34600142 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9525 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 20.83 cM, cytoband B
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    OPN4, opsin 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OPN4, opsin 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MOP
  • Links
    NCBI Gene ID: 94233
    neXtProt AC: NX_Q9UHM6

  • Chr Location
    10q22; chr10:86654557-86666460 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 5 alleles in 5 genetic backgrounds
    15 phenotypes from multigenic genotypes
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in absent intrinsic inner retinal photosensitivity, abnormal pupillary reflex, and abnormal circadian rhythms.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 30044 NCBI Gene Model | MGI Sequence Detail 9525 C57BL/6J ±  kb
transcript NM_001128599 RefSeq | MGI Sequence Detail 2259 Not Specified  
polypeptide Q9QXZ9 UniProt | EBI | MGI Sequence Detail 521 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    130 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 7
    cDNA 5
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2685379
References
more
  • Summaries
    All 112
    Developmental Gene Expression 9
    Gene Ontology 8
    Phenotypes 75
  • Earliest
    J:59329 Provencio I, et al., A novel human opsin in the inner retina. J Neurosci. 2000 Jan 15;20(2):600-5
  • Latest
    J:230434 Li S, et al., Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1937-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory