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Opn4
Gene Detail
Symbol

Name
ID
Opn4
opsin 4 (melanopsin)
MGI:1353425
Synonyms
1110007J02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 14
20.83 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:34590618-34600142 bp, - strand
From NCBI annotation of GRCm38

  9525 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69152  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: OPN4
Protein SuperFamily: animal opsin
Gene Tree: Opn4

Human
homologs
OPN4, opsin 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 94233
neXtProt AC: NX_Q9UHM6

Human Synonyms: MOP

Human Chr (Location): 10q22; chr10:86654557-86666460 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene results in absent intrinsic inner retinal photosensitivity, abnormal pupillary reflex, and abnormal circadian rhythms.
 
Interactions
Opn4 interacts with 123 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (17)    Tissues (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 17
cDNA source data(5)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA OPN4 ; Xenbase LOC100491785 ; ZFIN opn4a, opn4b    NEW 
Molecular
reagents
All nucleic(7) cDNA(5) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000021799 (Evidence)
Entrez Gene 30044 (Evidence)
UniGene 272060
DFCI TC1613638, TC1591660
DoTS DT.55202745, DT.40151610
NIA Mouse Gene Index U035415, U035416
Consensus CDS Project CCDS26943.1, CCDS49446.1
International Mouse Phenotyping Consortium Status Opn4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 30044 NCBI Gene Model | MGI Sequence Detail 9525 C57BL/6J ±  kb
transcript NM_001128599 RefSeq | MGI Sequence Detail 2259 Not Specified 
polypeptide Q9QXZ9 UniProt | EBI | MGI Sequence Detail 521 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(130 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001760 Opsin
InterPro IPR027430 Visual pigments (opsins) retinal binding site
Protein Ontology PR:000001243 melanopsin
Graphical View of Protein Domain Structure
References
(Earliest) J:59329 Provencio I, et al., A novel human opsin in the inner retina. J Neurosci. 2000 Jan 15;20(2):600-5
(Latest) J:220735 Wu F, et al., Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1559-68
All references(101)
Other
accession IDs
MGI:2685379

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory