Mfi2
Gene Detail

Symbol Name ID

Mfi2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 MGI:1353421

Synonyms

CD228, melanotransferrin, MTf

Feature Type

protein coding gene

Genetic Map

Chromosome 16

22.40 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:31878810-31899020 bp, + strand From NCBI annotation of GRCm38   20211 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4335  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transferrin
Gene Tree: Mfi2

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Mice homozygous for a knock-out allele are viable and fertile, exhibit no physical defects, and develop normally with no detectable alterations in iron metabolism.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	cellular iron ion homeostasis, ion transport, ...
Component	anchored to membrane, extracellular region, ...
Function	ferric iron binding, metal ion binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (58)    Tissues (24)    Images (18)
Theiler Stages: 13, 15, 20, 23, 26, 28

Assay Type	Results
RNA in situ	26
Northern blot	8
RT-PCR	24

cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(37) cDNA(36) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022780 (Evidence)
Entrez Gene	30060 (Evidence)
UniGene	30988
DFCI	TC1581562
DoTS	DT.491545
NIA Mouse Gene Index	U017004
Consensus CDS Project	CCDS28108.1
International Mouse Knockout Project Status	Mfi2

Sequences

Length	Strain/Species
genomic	30060	NCBI Gene Model | MGI Sequence Detail	20211	C57BL/6J
transcript	NM_013900	RefSeq | MGI Sequence Detail	4133	C57BL/6
polypeptide	Q9R0R1	UniProt | EBI | MGI Sequence Detail	738	Not Applicable

All sequences(15) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(162 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016357	Transferrin
InterPro	IPR001156	Transferrin family
InterPro	IPR018195	Transferrin family, iron binding site
Protein Ontology	PR:000001887	melanotransferrin

Graphical View of Protein Domain Structure

References

(Earliest) J:58252 Nakamasu K, et al., Membrane-bound transferrin-like protein (MTf): structure, evolution and selective expression during chondrogenic differentiation of mouse embryonic cells. Biochim Biophys Acta. 1999 Oct 28;1447(2-3):258-64
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)