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Mfi2
Gene Detail
Symbol

Name
ID
Mfi2
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MGI:1353421
Synonyms
CD228, melanotransferrin, MTf
Feature Type
protein coding gene
Genetic Map
Chromosome 16
22.40 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:31878810-31899020 bp, + strand
From Ensembl annotation of GRCm38

  20211 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4335  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transferrin
Gene Tree: Mfi2

Human
homologs
Human Homolog MFI2, antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
NCBI Gene ID 4241
neXtProt AC  NX_P08582
Human Synonyms  CD228, MAP97, MTF1
Human Chr (Location)  3q28-q29; chr3:196988621-197029816 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and fertile, exhibit no physical defects, and develop normally with no detectable alterations in iron metabolism.
 
Interactions
Mfi2 interacts with 190 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process ion transport, iron ion homeostasis, ...
Component anchored component of membrane, anchored component of plasma membrane, ...
Function ferric iron binding, iron ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (58)    Tissues (24)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
Northern blot 8
RT-PCR 24
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(36) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022780 (Evidence)
Entrez Gene30060 (Evidence)
UniGene30988
DFCITC1581562
DoTSDT.491545
NIA Mouse Gene IndexU017004
Consensus CDS ProjectCCDS28108.1
International Mouse Knockout Project StatusMfi2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022780 Ensembl Gene Model | MGI Sequence Detail 20211 C57BL/6J ±  kb
transcript ENSMUST00000023464 Ensembl | MGI Sequence Detail 4133 Not Applicable 
polypeptide ENSMUSP00000023464 Ensembl | MGI Sequence Detail 738 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(184 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016357 Transferrin
InterPro IPR001156 Transferrin family
InterPro IPR018195 Transferrin family, iron binding site
Protein Ontology PR:000001887 melanotransferrin
References
(Earliest) J:58252 Nakamasu K, et al., Membrane-bound transferrin-like protein (MTf): structure, evolution and selective expression during chondrogenic differentiation of mouse embryonic cells. Biochim Biophys Acta. 1999 Oct 28;1447(2-3):258-64
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory