About   Help   FAQ
Rnf17 Gene Detail
Summary
  • Symbol
    Rnf17
  • Name
    ring finger protein 17
  • Synonyms
    MMIP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353419
    NCBI Gene: 30054
Location & Maps
more
  • Sequence Map
    Chr14:56402697-56525032 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      122336 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.21 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RNF17, ring finger protein 17
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RNF17, ring finger protein 17
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Mmip-2, SPATA23, TDRD4
  • Links
    NCBI Gene ID: 56163
    neXtProt AC: NX_Q9BXT8

  • Chr Location
    13q12.12; chr13:24747672-24889262 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 23727
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: RNF17
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Targeted
    3
  • Genomic Mutations
    1 involving Rnf17
  • Incidental Mutations
Homozygous null mice display male infertility, azoospermia, arrest of spermatogenesis, and small testis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
  • Other Vertebrate Links
    Xenbase rnf17
    ZFIN rnf17
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000365 Ensembl Gene Model | MGI Sequence Detail 122336 C57BL/6J ±  kb
transcript ENSMUST00000095793 Ensembl | MGI Sequence Detail 5148 Not Applicable  
polypeptide ENSMUSP00000093469 Ensembl | MGI Sequence Detail 1640 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    442 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014103 RING finger protein 17
  • InterPro Domains
    IPR016071 Staphylococcal nuclease (SNase-like), OB-fold
    IPR002999 Tudor domain
    IPR001841 Zinc finger, RING-type
    IPR017907 Zinc finger, RING-type, conserved site
Molecular
Reagents
less
  • All nucleic 29
    cDNA 28
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 31
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:46395 Gupta K, et al., Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc. Oncogene. 1998 Mar 5;16(9):1149-59
  • Latest
    J:225723 Wasik KA, et al., RNF17 blocks promiscuous activity of PIWI proteins in mouse testes. Genes Dev. 2015 Jul 1;29(13):1403-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory