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Rnf17 Gene Detail
Summary
  • Symbol
    Rnf17
  • Name
    ring finger protein 17
  • Synonyms
    MMIP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353419
    NCBI Gene: 30054
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:56402634-56525032 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      122399 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.21 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RNF17, ring finger protein 17
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RNF17, ring finger protein 17
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Mmip-2, SPATA23, TDRD4
  • Links
    NCBI Gene ID: 56163
    neXtProt AC: NX_Q9BXT8
    UniProt: Q9BXT8

  • Chr Location
    13q12.12; chr13:24747641-24888816 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 23727
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RNF17
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display male infertility, azoospermia, arrest of spermatogenesis, and small testis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30054 NCBI Gene Model | MGI Sequence Detail 122399 C57BL/6J ±  kb
    transcript NM_001033043 RefSeq | MGI Sequence Detail 5148 Not Specified  
    polypeptide Q99MV7 UniProt | EBI | MGI Sequence Detail 1640 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      442 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 4
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:46395 Gupta K, et al., Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc. Oncogene. 1998 Mar 5;16(9):1149-59
    • Latest
      J:225723 Wasik KA, et al., RNF17 blocks promiscuous activity of PIWI proteins in mouse testes. Genes Dev. 2015 Jul 1;29(13):1403-15

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory