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Ulk2
Gene Detail
 Symbol
Name
ID
Ulk2
unc-51 like kinase 2
MGI:1352758
Synonyms A830085I22Rik, mKIAA0623, Unc51.2
Feature Type protein coding gene
Genetic Map
Chromosome 11
37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:61775649-61855073 bp, - strand
From VEGA annotation of GRCm38

  79425 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5891  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serine/threonine-protein kinase, ULK1/2 types
Gene Tree: Ulk2

Human
homologs
Human Homolog ULK2, unc-51 like autophagy activating kinase 2
NCBI Gene ID 9706
neXtProt AC  NX_Q8IYT8
Human Synonyms  ATG1B, Unc51.2
Human Chr (Location)  17p11.2; chr17:19770830-19867926 (-)  GRCh38
Alleles
and
phenotypes
All alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in an increased anxiety-like response in males.
 
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process autophagic vacuole assembly, autophagy, ...
Component Atg1p signaling complex, cytoplasmic vesicle, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (7)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000005846 (Evidence)
Ensembl Gene ModelENSMUSG00000004798 (Evidence)
Entrez Gene29869 (Evidence)
DFCITC1575105, TC1599131, TC1643884, TC1657235, TC1737475
DoTSDT.101736489, DT.485956, DT.60100261
NIA Mouse Gene IndexU032895
EC2.7.11.1
Consensus CDS ProjectCCDS24820.1
International Mouse Knockout Project StatusUlk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005846 VEGA Gene Model | MGI Sequence Detail 79425 C57BL/6J ±  kb
transcript OTTMUST00000013001 VEGA | MGI Sequence Detail 5743 Not Applicable 
polypeptide OTTMUSP00000006044 VEGA | MGI Sequence Detail 1037 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(279 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR022708 Serine/threonine-protein kinase, C-terminal
InterPro IPR016237 Serine/threonine-protein kinase, Ulk1/Ulk2
Protein Ontology PR:000017078 serine/threonine-protein kinase ULK2
References (Earliest) J:47612 Yan J, et al., Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Biochem Biophys Res Commun. 1998 May 8;246(1):222-7
(Latest) J:183836 Gammoh N, et al., Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6561-5
All references(45)
Other
accession IDs
MGI:2144370, MGI:2444180

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory