About   Help   FAQ
Ulk2
Gene Detail
Symbol

Name
ID
Ulk2
unc-51 like kinase 2
MGI:1352758
Synonyms
A830085I22Rik, mKIAA0623, Unc51.2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:61775649-61855073 bp, - strand
From VEGA annotation of GRCm38

  79425 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5891  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ULK2
Protein SuperFamily: serine/threonine-protein kinase, ULK1/2 types
Gene Tree: Ulk2

Human
homologs
ULK2, unc-51 like autophagy activating kinase 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9706
neXtProt AC: NX_Q8IYT8

Human Synonyms: ATG1B, Unc51.2

Human Chr (Location): 17p11.2; chr17:19770828-19867926 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in an increased anxiety-like response in males.
 
Interactions
Ulk2 interacts with 375 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process autophagic vacuole assembly, autophagy, ...
Component ATG1/UKL1 signaling complex, cytoplasmic vesicle, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ulk2 ; ZFIN ulk2    NEW 
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000005846 (Evidence)
Ensembl Gene Model ENSMUSG00000004798 (Evidence)
Entrez Gene 29869 (Evidence)
DFCI TC1643884, TC1599131, TC1575105, TC1737475, TC1657235
DoTS DT.101736489, DT.60100261, DT.485956
NIA Mouse Gene Index U032895
EC 2.7.11.1
Consensus CDS Project CCDS24820.1
International Mouse Phenotyping Consortium Status Ulk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005846 VEGA Gene Model | MGI Sequence Detail 79425 C57BL/6J ±  kb
transcript OTTMUST00000013001 VEGA | MGI Sequence Detail 5743 Not Applicable 
polypeptide OTTMUSP00000006044 VEGA | MGI Sequence Detail 1037 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(279 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR022708 Serine/threonine-protein kinase, C-terminal
InterPro IPR016237 Serine/threonine-protein kinase, Ulk1/Ulk2
Protein Ontology PR:000017078 serine/threonine-protein kinase ULK2
References
(Earliest) J:47612 Yan J, et al., Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Biochem Biophys Res Commun. 1998 May 8;246(1):222-7
(Latest) J:183836 Gammoh N, et al., Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6561-5
All references(43)
Other
accession IDs
MGI:2144370, MGI:2444180

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory