Ulk2
Gene Detail

Symbol Name ID

Ulk2 unc-51 like kinase 2 MGI:1352758

Synonyms

A830085I22Rik, mKIAA0623, Unc51.2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:61775649-61855073 bp, - strand From VEGA annotation of GRCm38   79425 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ulk2 ± 2 cM)

Protein SuperFamily: serine/threonine-protein kinase, ULK1/2 types
Gene Tree: Ulk2

Human ortholog

ULK2 unc-51-like kinase 2 (C. elegans) NCBI Gene ID 9706
Human Synonyms: ATG1B, Unc51.2
Human Chr17:19674143-19771239 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(10) : Targeted(5) Gene trapped(5)
 

Homozygous mutation of this gene results in an increased anxiety-like response in males.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	autophagy, axon extension, ...
Component	cytoplasmic vesicle, membrane, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (7)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000005846 (Evidence)
Ensembl Gene Model	ENSMUSG00000004798 (Evidence)
Entrez Gene	29869 (Evidence)
DFCI	TC1575105, TC1599131, TC1643884, TC1657235, TC1737475
DoTS	DT.101736489, DT.485956, DT.60100261
NIA Mouse Gene Index	U032895
EC	2.7.11.1
Consensus CDS Project	CCDS24820.1
International Mouse Knockout Project Status	Ulk2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005846	VEGA Gene Model | MGI Sequence Detail	79425	C57BL/6J
transcript	OTTMUST00000013001	VEGA | MGI Sequence Detail	5743	Not Applicable
polypeptide	OTTMUSP00000006044	VEGA | MGI Sequence Detail	1037	Not Applicable

All sequences(49) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(92 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
InterPro	IPR022708	Serine/threonine-protein kinase, C-terminal
InterPro	IPR016237	Serine/threonine-protein kinase, Ulk1/Ulk2
Protein Ontology	PR:000017078	serine/threonine-protein kinase ULK2

References

(Earliest) J:47612 Yan J, et al., Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Biochem Biophys Res Commun. 1998 May 8;246(1):222-7
(Latest) J:183836 Gammoh N, et al., Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6561-5
All references(44)

Other accession IDs

MGI:2144370, MGI:2444180