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Ulk2 Gene Detail
Summary
  • Symbol
    Ulk2
  • Name
    unc-51 like kinase 2
  • Synonyms
    A830085I22Rik, mKIAA0623, Unc51.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352758
    NCBI Gene: 29869
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61666475-61745899 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    276 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352758
protein coding gene Chr11:61666424-61750754 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018447
protein coding gene Chr11:61752446-61840573 (-)
A/J MGP_AJ_G0018416
protein coding gene Chr11:59480650-59574429 (-)
AKR/J MGP_AKRJ_G0018386
protein coding gene Chr11:61317302-61400836 (-)
BALB/cJ MGP_BALBcJ_G0018387
protein coding gene Chr11:59779410-59859268 (-)
C3H/HeJ MGP_C3HHeJ_G0018200
protein coding gene Chr11:61306425-61392293 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018839
protein coding gene Chr11:63712741-63807464 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016485
protein coding gene Chr11:56592182-56678034 (-)
CAST/EiJ MGP_CASTEiJ_G0017757
protein coding gene Chr11:61409991-61504509 (-)
CBA/J MGP_CBAJ_G0018174
protein coding gene Chr11:66482741-66579554 (-)
DBA/2J MGP_DBA2J_G0018283
protein coding gene Chr11:59044799-59126359 (-)
FVB/NJ MGP_FVBNJ_G0018274
protein coding gene Chr11:58729963-58810674 (-)
LP/J MGP_LPJ_G0018356
protein coding gene Chr11:62324851-62406047 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018298
protein coding gene Chr11:67467880-67580131 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018880
protein coding gene Chr11:61465178-61545684 (-)
PWK/PhJ MGP_PWKPhJ_G0017530
protein coding gene Chr11:59652515-59734461 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017320
protein coding gene Chr11:61286983-61370695 (-)
WSB/EiJ MGP_WSBEiJ_G0017809
protein coding gene Chr11:61065409-61151469 (-)



Homology
more
  • Human Ortholog
    ULK2, unc-51 like autophagy activating kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ULK2, unc-51 like autophagy activating kinase 2
  • Synonyms
    ATG1B, Unc51.2
  • Links
    NCBI Gene ID: 9706
    neXtProt AC: NX_Q8IYT8
    UniProt: Q8IYT8

  • Chr Location
    17p11.2; chr17:19770829-19867936 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in an increased anxiety-like response in males.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004798 Ensembl Gene Model | MGI Sequence Detail 79425 C57BL/6J ±  kb
transcript ENSMUST00000004920 Ensembl | MGI Sequence Detail 5743 Not Applicable  
polypeptide ENSMUSP00000004920 Ensembl | MGI Sequence Detail 1037 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2144370, MGI:2444180
References
more
  • Summaries
    All 60
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 23
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345168 Kremer LS, et al., A role for BCL2L13 and autophagy in germline purifying selection of mtDNA. PLoS Genet. 2023 Jan;19(1):e1010573

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory