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Iqgap1
Gene Detail
Symbol

Name
ID
Iqgap1
IQ motif containing GTPase activating protein 1
MGI:1352757
Synonyms
D7Ertd237e, D7Ertd257e, mKIAA0051
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:80711583-80803331 bp, - strand
From Ensembl annotation of GRCm38

  91749 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74514  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IQGAP1
Gene Tree: Iqgap1

Human
homologs
IQGAP1, IQ motif containing GTPase activating protein 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8826
neXtProt AC: NX_P46940

Human Synonyms: HUMORFA01, p195, SAR1

Human Chr (Location): 15q26.1; chr15:90388241-90502243 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(111) : Gene trapped(108) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null allele exhibit a late-onset gastric hyperplasia.
 
Interactions
Iqgap1 interacts with 330 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process activation of protein kinase activity, cellular response to calcium ion, ...
Component actin cytoskeleton, axon, ...
Function calmodulin binding, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (116)    Tissues (25)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 100
RT-PCR 6
cDNA source data(306)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA IQGAP1 ; Xenbase iqgap1    NEW 
Molecular
reagents
All nucleic(313) cDNA(310) Primer pair(3)
Microarray probesets(9)
Other database
links
Ensembl Gene Model ENSMUSG00000030536 (Evidence)
Entrez Gene 29875 (Evidence)
UniGene 207619
DFCI TC1710607, TC1572480, TC1678852, TC1602695, TC1589506, TC1781162
DoTS DT.55132571, DT.536796, DT.101175674, DT.101382700, DT.101382698, DT.101306010, DT.94232708
NIA Mouse Gene Index U028769
Consensus CDS Project CCDS40001.1
International Mouse Phenotyping Consortium Status Iqgap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030536 Ensembl Gene Model | MGI Sequence Detail 91749 C57BL/6J ±  kb
transcript ENSMUST00000167377 Ensembl | MGI Sequence Detail 7359 Not Applicable 
polypeptide ENSMUSP00000128278 Ensembl | MGI Sequence Detail 1657 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(5) UniProt(12)
Polymorphisms
SNPs within 2kb(805 from dbSNP Build 137)    SNPs within 2kb including multiple locations(809)
Protein-related
information
ResourceIDDescription
InterPro IPR001715 Calponin homology domain
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000593 RasGAP protein, C-terminal
InterPro IPR001936 Ras GTPase-activating protein
InterPro IPR023152 Ras GTPase-activating protein, conserved site
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001202 WW domain
Protein Ontology PR:000009095 ras GTPase-activating-like protein IQGAP1
References
(Earliest) J:59215 Li S, et al., Gastric hyperplasia in mice lacking the putative cdc42 effector IQGAP1. Mol Cell Biol. 2000 Jan;20(2):697-701
(Latest) J:217611 Bhattacharya M, et al., IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. J Clin Invest. 2014 Nov;124(11):4895-8
All references(68)
Other
accession IDs
MGI:1098558, MGI:1098580, MGI:2141849

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory