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Iqgap1 Gene Detail
Summary
  • Symbol
    Iqgap1
  • Name
    IQ motif containing GTPase activating protein 1
  • Synonyms
    D7Ertd237e, D7Ertd257e, mKIAA0051
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352757
    NCBI Gene: 29875
  • Gene Overview
    MyGene.info: IQGAP1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:80711583-80825974 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      114392 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.68 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IQGAP1, IQ motif containing GTPase activating protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IQGAP1, IQ motif containing GTPase activating protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HUMORFA01, p195, SAR1
  • Links
    NCBI Gene ID: 8826
    neXtProt AC: NX_P46940
    UniProt: P46940

  • Chr Location
    15q26.1; chr15:90388241-90502243 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null allele exhibit a late-onset gastric hyperplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000058690 VEGA Gene Model | MGI Sequence Detail 114392 C57BL/6J ±  kb
    transcript OTTMUST00000144162 VEGA | MGI Sequence Detail 7444 Not Applicable  
    polypeptide OTTMUSP00000075167 VEGA | MGI Sequence Detail 1657 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      925 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 316
      cDNA 312
      Primer pair 4

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1098558, MGI:1098580, MGI:2141849
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 8
      Gene Ontology 12
      Phenotypes 35
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:253300 Shen X, et al., HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures. Cell Commun Signal. 2017 Jan 5;15(1):2

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory