About   Help   FAQ
Iqgap1
Gene Detail
 Symbol
Name
ID
Iqgap1
IQ motif containing GTPase activating protein 1
MGI:1352757
Synonyms D7Ertd237e, D7Ertd257e, mKIAA0051
Feature Type protein coding gene
Genetic Map
Chromosome 7
45.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:80711583-80803331 bp, - strand
From NCBI annotation of GRCm38

  91749 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74514  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Iqgap1

Human
homologs
Human Homolog IQGAP1, IQ motif containing GTPase activating protein 1
NCBI Gene ID 8826
neXtProt AC  NX_P46940
Human Synonyms  HUMORFA01, p195, SAR1
Human Chr (Location)  15q26.1; chr15:90388241-90502243 (+)  GRCh38
Alleles
and
phenotypes
All alleles(111) : Gene trapped(108) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null allele exhibit a late-onset gastric hyperplasia.
 
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process cellular response to calcium ion, cellular response to epidermal growth factor stimulus, ...
Component cell-cell junction, cell junction, ...
Function calmodulin binding, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (122)    Tissues (28)    Images (32)
Theiler Stages: 2, 3, 4, 5, 23, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 100
RT-PCR 12
cDNA source data(306)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(313) cDNA(310) Primer pair(3)
Microarray probesets(9)
Other database
links
Ensembl Gene ModelENSMUSG00000030536 (Evidence)
Entrez Gene29875 (Evidence)
UniGene207619
DFCITC1572480, TC1589506, TC1602695, TC1678852, TC1710607, TC1781162
DoTSDT.101175674, DT.101306010, DT.101382698, DT.101382700, DT.536796, DT.55132571, DT.94232708
NIA Mouse Gene IndexU028769
Consensus CDS ProjectCCDS40001.1
International Mouse Knockout Project StatusIqgap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 29875 NCBI Gene Model | MGI Sequence Detail 91749 C57BL/6J ±  kb
transcript NM_016721 RefSeq | MGI Sequence Detail 7377 C57BL/6 
polypeptide Q9JKF1 UniProt | EBI | MGI Sequence Detail 1657 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(7) UniProt(12)
Polymorphisms SNPs within 2kb(805 from dbSNP Build 137)    SNPs within 2kb including multiple locations(809)
Protein-related
information
ResourceIDDescription
InterPro IPR001715 Calponin homology domain
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000593 RasGAP protein, C-terminal
InterPro IPR001936 Ras GTPase-activating protein
InterPro IPR023152 Ras GTPase-activating protein, conserved site
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001202 WW domain
Protein Ontology PR:000009095 ras GTPase-activating-like protein IQGAP1
Graphical View of Protein Domain Structure
References (Earliest) J:59215 Li S, et al., Gastric hyperplasia in mice lacking the putative cdc42 effector IQGAP1. Mol Cell Biol. 2000 Jan;20(2):697-701
(Latest) J:210123 Kohno T, et al., IQGAP1 links PDGF receptor-beta signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury. Am J Physiol Cell Physiol. 2013 Sep 15;305(6):C591-600
All references(66)
Other
accession IDs
MGI:1098558, MGI:1098580, MGI:2141849

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory