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Clic4 Gene Detail
Summary
  • Symbol
    Clic4
  • Name
    chloride intracellular channel 4 (mitochondrial)
  • Synonyms
    D0Jmb3, mc3s5, mtCLIC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352754
    NCBI Gene: 29876
  • Gene Overview
    MyGene.info: CLIC4
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:135213969-135272760 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 67.19 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    708 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352754
protein coding gene Chr4:135213969-135272814 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028940
protein coding gene Chr4:137631001-137692955 (-)
A/J MGP_AJ_G0028899
protein coding gene Chr4:131822965-131885265 (-)
AKR/J MGP_AKRJ_G0028851
protein coding gene Chr4:135611658-135680227 (-)
BALB/cJ MGP_BALBcJ_G0028923
protein coding gene Chr4:132477960-132537549 (-)
C3H/HeJ MGP_C3HHeJ_G0028637
protein coding gene Chr4:135875672-135939077 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029364
protein coding gene Chr4:142558561-142626134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026635
protein coding gene Chr4:124876182-124936910 (-)
CAST/EiJ MGP_CASTEiJ_G0028069
protein coding gene Chr4:133997539-134068034 (-)
CBA/J MGP_CBAJ_G0028602
protein coding gene Chr4:146352036-146507190 (-)
DBA/2J MGP_DBA2J_G0028751
protein coding gene Chr4:132244232-132303451 (-)
FVB/NJ MGP_FVBNJ_G0028718
protein coding gene Chr4:131160249-131219194 (-)
LP/J MGP_LPJ_G0028850
protein coding gene Chr4:137738779-137799574 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028744
protein coding gene Chr4:150770670-150833728 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029402
protein coding gene Chr4:136061982-136126831 (-)
PWK/PhJ MGP_PWKPhJ_G0027789
protein coding gene Chr4:129007403-129070219 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027615
protein coding gene Chr4:131892412-131952240 (-)
WSB/EiJ MGP_WSBEiJ_G0028147
protein coding gene Chr4:136237419-136298569 (-)



Homology
more
  • Human Ortholog
    CLIC4, chloride intracellular channel 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLIC4, chloride intracellular channel 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CLIC4L, H1, huH1, MTCLIC, p64H1
  • Links
    NCBI Gene ID: 25932
    neXtProt AC: NX_Q9Y696
    UniProt: Q9Y696

  • Chr Location
    1p36.11; chr1:24745269-24844324 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 4 alleles in 5 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations may display decreased survival, body weight and female fertility, impaired angiogenesis, increased suscpetibility to Listeria infection, increased resistance to LPS treatment, skin erosions and/or delayed wound healing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 29876 NCBI Gene Model | MGI Sequence Detail 58792 C57BL/6J ±  kb
    transcript NM_013885 RefSeq | MGI Sequence Detail 4065 C57BL/6  
    polypeptide Q9QYB1 UniProt | EBI | MGI Sequence Detail 253 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005577 chloride intracellular channel protein 4
    • InterPro Domains
      IPR030257 Chloride intracellular channel protein 4
      IPR036282 Glutathione S-transferase, C-terminal domain superfamily
      IPR010987 Glutathione S-transferase, C-terminal-like
      IPR040079 Glutathione Transferase family
      IPR002946 Intracellular chloride channel
      IPR036249 Thioredoxin-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 406
      cDNA 405
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1206574
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 22
    • Earliest
      J:25193 Gordon HM, et al., Tumor necrosis factor induces genes involved in inflammation, cellular and tissue repair, and metabolism in murine fibroblasts. J Immunol. 1992 Jun 15;148(12):4021-7
    • Latest
      J:250729 Tang T, et al., CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Nat Commun. 2017 Aug 04;8(1):202

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory