About   Help   FAQ
Clic4
Gene Detail
Symbol

Name
ID
Clic4
chloride intracellular channel 4 (mitochondrial)
MGI:1352754
Synonyms
D0Jmb3, mc3s5, mtCLIC
Feature Type
protein coding gene
Genetic Map
Chromosome 4
67.19 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:135213969-135272814 bp, - strand
From VEGA annotation of GRCm38

  58846 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: chloride intracellular channel protein
Gene Tree: Clic4

Human
homologs
Human Homolog CLIC4, chloride intracellular channel 4
NCBI Gene ID 25932
neXtProt AC  NX_Q9Y696
Human Synonyms  CLIC4L, H1, huH1, MTCLIC, p64H1
Human Chr (Location)  1p36.11; chr1:24745269-24844324 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(53) : Gene trapped(46) Targeted(7)
Incidental mutations (data from APF )
 
Mice homozygous for null mutations may display decreased survival, body weight and female fertility, impaired angiogenesis, increased suscpetibility to Listeria infection, increased resistance to LPS treatment, skin erosions and/or delayed wound healing.
 
Interactions
Clic4 interacts with 305 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process angiogenesis, branching morphogenesis of an epithelial tube, ...
Component apical part of cell, cell, ...
Function chloride channel activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(403)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(404) cDNA(404)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000009685 (Evidence)
Ensembl Gene ModelENSMUSG00000037242 (Evidence)
Entrez Gene29876 (Evidence)
UniGene257765
DFCITC1573258, TC1732083, TC1637083
DoTSDT.110823568, DT.91403172, DT.536684
NIA Mouse Gene IndexU165340, U025654, U379956, U375528, U061496
Consensus CDS ProjectCCDS18783.1
International Mouse Knockout Project StatusClic4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009685 VEGA Gene Model | MGI Sequence Detail 58846 C57BL/6J ±  kb
transcript OTTMUST00000022374 VEGA | MGI Sequence Detail 4119 Not Applicable 
polypeptide OTTMUSP00000010203 VEGA | MGI Sequence Detail 253 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(713 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010987 Glutathione S-transferase, C-terminal-like
InterPro IPR004045 Glutathione S-transferase, N-terminal
InterPro IPR002946 Intracellular chloride channel
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000005577 chloride intracellular channel protein 4
References
(Earliest) J:25193 Gordon HM, et al., Tumor necrosis factor induces genes involved in inflammation, cellular and tissue repair, and metabolism in murine fibroblasts. J Immunol. 1992 Jun 15;148(12):4021-7
(Latest) J:213573 Padmakumar V, et al., Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line. BMC Dev Biol. 2014;14:24
All references(50)
Other
accession IDs
MGI:1206574

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory