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Clic4 Gene Detail
Summary
  • Symbol
    Clic4
  • Name
    chloride intracellular channel 4 (mitochondrial)
  • Synonyms
    D0Jmb3, mc3s5, mtCLIC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352754
    NCBI Gene: 29876
  • Gene Overview
    MyGene.info: CLIC4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:135213969-135272814 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58846 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 67.19 cM, cytoband D3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CLIC4, chloride intracellular channel 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLIC4, chloride intracellular channel 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLIC4L, H1, huH1, MTCLIC, p64H1
  • Links
    NCBI Gene ID: 25932
    neXtProt AC: NX_Q9Y696
    UniProt: Q9Y696

  • Chr Location
    1p36.11; chr1:24745269-24844324 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 4 alleles in 5 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations may display decreased survival, body weight and female fertility, impaired angiogenesis, increased suscpetibility to Listeria infection, increased resistance to LPS treatment, skin erosions and/or delayed wound healing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000009685 VEGA Gene Model | MGI Sequence Detail 58846 C57BL/6J ±  kb
    transcript OTTMUST00000022374 VEGA | MGI Sequence Detail 4119 Not Applicable  
    polypeptide OTTMUSP00000010203 VEGA | MGI Sequence Detail 253 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      709 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005577 chloride intracellular channel protein 4
    • InterPro Domains
      IPR030257 Chloride intracellular channel protein 4
      IPR036282 Glutathione S-transferase, C-terminal domain superfamily
      IPR010987 Glutathione S-transferase, C-terminal-like
      IPR002946 Intracellular chloride channel
      IPR036249 Thioredoxin-like superfamily
    Molecular
    Reagents
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    • All nucleic 407
      cDNA 406
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1206574
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 22
    • Earliest
      J:25193 Gordon HM, et al., Tumor necrosis factor induces genes involved in inflammation, cellular and tissue repair, and metabolism in murine fibroblasts. J Immunol. 1992 Jun 15;148(12):4021-7
    • Latest
      J:250729 Tang T, et al., CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Nat Commun. 2017 Aug 04;8(1):202

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory