About   Help   FAQ
Gipr
Gene Detail
 Symbol
Name
ID
Gipr
gastric inhibitory polypeptide receptor
MGI:1352753
Synonyms glucose-dependent insulinotropic polypeptide receptor, LOC232937, LOC381853
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:19157125-19166127 bp, - strand
From NCBI annotation of GRCm38

  9003 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20081  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Gipr

Human
homologs
Human Homolog GIPR, gastric inhibitory polypeptide receptor
NCBI Gene ID 2696
neXtProt AC  NX_P48546
Human Synonyms  PGQTL2
Human Chr (Location)  19q13.3; chr19:45668244-45682459 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GIPR
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Gene trapped(1)
 
Homozygous inactivation of this gene results in mild glucose intolerance due to impaired glucose-stimulated insulin secretion.
 
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell surface receptor signaling pathway, desensitization of G-protein coupled receptor protein signaling pathway, ...
Component integral component of membrane, membrane, ...
Function gastric inhibitory peptide receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (21)    Tissues (9)   
Theiler Stages: 15, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 8
RT-PCR 13
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000030406 (Evidence)
Entrez Gene381853 (Evidence)
UniGene333633
DFCITC1655215
DoTSDT.101354716, DT.91288988
NIA Mouse Gene IndexU028216
Consensus CDS ProjectCCDS39795.1
International Mouse Knockout Project StatusGipr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 381853 NCBI Gene Model | MGI Sequence Detail 9003 C57BL/6J ±  kb
transcript NM_001080815 RefSeq | MGI Sequence Detail 1792 Not Specified 
polypeptide Q0P543 UniProt | EBI | MGI Sequence Detail 460 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(22) UniProt(1)
Polymorphisms SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR001749 GPCR, family 2, gastric inhibitory polypeptide receptor
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000007988 gastric inhibitory polypeptide receptor
Graphical View of Protein Domain Structure
References (Earliest) J:59087 Miyawaki K, et al., Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14843-7
(Latest) J:203708 Mieczkowska A, et al., Glucose-dependent insulinotropic polypeptide (GIP) receptor deletion leads to reduced bone strength and quality. Bone. 2013 Oct;56(2):337-42
All references(59)
Other
accession IDs
MGI:2685006, MGI:2685927

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory