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Gipr Gene Detail
Summary
  • Symbol
    Gipr
  • Name
    gastric inhibitory polypeptide receptor
  • Synonyms
    glucose-dependent insulinotropic polypeptide receptor, LOC232937, LOC381853
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352753
    NCBI Gene: 381853
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:19156061-19166127 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10067 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.46 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GIPR, gastric inhibitory polypeptide receptor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GIPR, gastric inhibitory polypeptide receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PGQTL2
  • Links
    NCBI Gene ID: 2696
    neXtProt AC: NX_P48546
    UniProt: P48546

  • Chr Location
    19q13.32; chr19:45668187-45683724 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in mild glucose intolerance due to impaired glucose-stimulated insulin secretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000058589 VEGA Gene Model | MGI Sequence Detail 10067 C57BL/6J ±  kb
    transcript OTTMUST00000143869 VEGA | MGI Sequence Detail 2856 Not Applicable  
    polypeptide OTTMUSP00000074998 VEGA | MGI Sequence Detail 460 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      137 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007988 gastric inhibitory polypeptide receptor
    • InterPro Domains
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR001749 GPCR, family 2, gastric inhibitory polypeptide receptor
      IPR017981 GPCR, family 2-like
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 10
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2685006, MGI:2685927
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 44
    • Earliest
      J:59087 Miyawaki K, et al., Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14843-7
    • Latest
      J:262188 Maekawa R, et al., Glucose-dependent insulinotropic polypeptide is required for moderate high-fat diet- but not high-carbohydrate diet-induced weight gain. Am J Physiol Endocrinol Metab. 2018 Jun 1;314(6):E572-E583

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory