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Gipr Gene Detail
Summary
  • Symbol
    Gipr
  • Name
    gastric inhibitory polypeptide receptor
  • Synonyms
    glucose-dependent insulinotropic polypeptide receptor, LOC232937, LOC381853
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352753
    NCBI Gene: 381853
Location & Maps
more
  • Sequence Map
    Chr7:19156061-19166127 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10067 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.46 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GIPR, gastric inhibitory polypeptide receptor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GIPR, gastric inhibitory polypeptide receptor
    Orthology source: HomoloGene
  • Synonyms
    PGQTL2
  • Links
    NCBI Gene ID: 2696
    neXtProt AC: NX_P48546

  • Chr Location
    19q13.3; chr19:45668193-45682504 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GIPR associations

Human Disease Mouse Models
       Gastric Inhibitory Polypeptide Receptor; GIPR   OMIM: 137241
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    1
  • Targeted
    4
  • Incidental Mutations
    APF , CvDC
Homozygous inactivation of this gene results in mild glucose intolerance due to impaired glucose-stimulated insulin secretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058589 VEGA Gene Model | MGI Sequence Detail 10067 C57BL/6J ±  kb
transcript OTTMUST00000143869 VEGA | MGI Sequence Detail 2856 Not Applicable  
polypeptide OTTMUSP00000074998 VEGA | MGI Sequence Detail 460 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    137 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007988 gastric inhibitory polypeptide receptor
  • InterPro Domains
    IPR001879 GPCR, family 2, extracellular hormone receptor domain
    IPR001749 GPCR, family 2, gastric inhibitory polypeptide receptor
    IPR017981 GPCR, family 2-like
    IPR000832 GPCR, family 2, secretin-like
    IPR017983 GPCR, family 2, secretin-like, conserved site
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGI:2685006, MGI:2685927
References
more
  • Summaries
    All 65
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 37
  • Earliest
    J:59087 Miyawaki K, et al., Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14843-7
  • Latest
    J:230560 Moffett RC, et al., Functional GIP receptors play a major role in islet compensatory response to high fat feeding in mice. Biochim Biophys Acta. 2015 Jun;1850(6):1206-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory