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Gipr
Gene Detail
Symbol

Name
ID
Gipr
gastric inhibitory polypeptide receptor
MGI:1352753
Synonyms
glucose-dependent insulinotropic polypeptide receptor, LOC232937, LOC381853
Feature Type
protein coding gene
Genetic Map
Chromosome 7
9.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:19157125-19166127 bp, - strand
From Ensembl annotation of GRCm38

  9003 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20081  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: GIPR
Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Gipr

Human
homologs
GIPR, gastric inhibitory polypeptide receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2696
neXtProt AC: NX_P48546

Human Synonyms: PGQTL2

Human Chr (Location): 19q13.3; chr19:45668193-45682504 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GIPR

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from APF , CvDC )
 
Homozygous inactivation of this gene results in mild glucose intolerance due to impaired glucose-stimulated insulin secretion.
 
Interactions
Gipr interacts with 55 markers (Mir150, Mir185, Mir187, ...)
Expression
Literature Summary: (2 records)
Data Summary: Results (21)    Tissues (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RT-PCR 13
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gipr    NEW 
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000030406 (Evidence)
Entrez Gene 381853 (Evidence)
UniGene 333633
DFCI TC1655215
DoTS DT.91288988, DT.101354716
NIA Mouse Gene Index U028216
Consensus CDS Project CCDS39795.1
International Mouse Phenotyping Consortium Status Gipr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030406 Ensembl Gene Model | MGI Sequence Detail 9003 C57BL/6J ±  kb
transcript ENSMUST00000094790 Ensembl | MGI Sequence Detail 1792 Not Applicable 
polypeptide ENSMUSP00000092384 Ensembl | MGI Sequence Detail 460 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(18) UniProt(1)
Polymorphisms
SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR001749 GPCR, family 2, gastric inhibitory polypeptide receptor
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000007988 gastric inhibitory polypeptide receptor
References
(Earliest) J:59087 Miyawaki K, et al., Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14843-7
(Latest) J:220741 Malmgren S, et al., DPP-4 inhibition contributes to the prevention of hypoglycaemia through a GIP-glucagon counterregulatory axis in mice. Diabetologia. 2015 May;58(5):1091-9
All references(64)
Other
accession IDs
MGI:2685006, MGI:2685927

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory