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Cabp2 Gene Detail
Summary
  • Symbol
    Cabp2
  • Name
    calcium binding protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352749
    NCBI Gene: 29866
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4081578-4087340 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 3.79 cM, cytoband A
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352749
protein coding gene Chr19:4081469-4087340 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024644
protein coding gene Chr19:911624-917386 (+)
A/J MGP_AJ_G0024610
protein coding gene Chr19:882751-888513 (+)
AKR/J MGP_AKRJ_G0024583
protein coding gene Chr19:901608-907370 (+)
BALB/cJ MGP_BALBcJ_G0024610
protein coding gene Chr19:871617-877379 (+)
C3H/HeJ MGP_C3HHeJ_G0024378
protein coding gene Chr19:899136-904898 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025058
protein coding gene Chr19:945854-951616 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022487
protein coding gene Chr19:824397-830137 (+)
CAST/EiJ MGP_CASTEiJ_G0023850
protein coding gene Chr19:907134-912908 (+)
CBA/J MGP_CBAJ_G0024349
protein coding gene Chr19:1008617-1014379 (+)
DBA/2J MGP_DBA2J_G0024477
protein coding gene Chr19:842312-848074 (+)
FVB/NJ MGP_FVBNJ_G0024444
protein coding gene Chr19:850379-856141 (+)
LP/J MGP_LPJ_G0024563
protein coding gene Chr19:904679-910441 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024474
protein coding gene Chr19:957365-963127 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025105
protein coding gene Chr19:902107-907869 (+)
PWK/PhJ MGP_PWKPhJ_G0023596
protein coding gene Chr19:893379-899137 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023401
protein coding gene Chr19:885189-890924 (+)
WSB/EiJ MGP_WSBEiJ_G0023912
protein coding gene Chr19:885223-890986 (+)



Homology
more
  • Human Ortholog
    CABP2, calcium binding protein 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CABP2, calcium binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNB93
  • Links
    NCBI Gene ID: 51475
    neXtProt AC: NX_Q9NPB3
    UniProt: Q9NPB3

  • Chr Location
    11q13.2; chr11:67518947-67523428 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8487
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CABP2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Cabp2 mouse models; 1 with human CABP2 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout affects calcium channels in cochlear inner hair cell synapses, resulting in hearing impairment. It also affects transmission of responses to light through the retinal circuits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024857 Ensembl Gene Model | MGI Sequence Detail 5763 C57BL/6J ±  kb
transcript ENSMUST00000162908 Ensembl | MGI Sequence Detail 911 Not Applicable  
polypeptide ENSMUSP00000125255 Ensembl | MGI Sequence Detail 221 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 4
References
more
  • Summaries
    All 28
    Diseases 1
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:59389 Haeseleer F, et al., Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem. 2000 Jan 14;275(2):1247-60
  • Latest
    J:272704 Yang T, et al., Functions of CaBP1 and CaBP2 in the peripheral auditory system. Hear Res. 2018 Jul;364:48-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory