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Cspg5 Gene Detail
Summary
  • Symbol
    Cspg5
  • Name
    chondroitin sulfate proteoglycan 5
  • Synonyms
    CALEB, neuroglycan C, NGC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352747
    NCBI Gene: 29873
  • Gene Overview
    MyGene.info: CSPG5
Location & Maps
more
  • Sequence Map
    Chr9:110243783-110262576 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18794 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CSPG5, chondroitin sulfate proteoglycan 5
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CSPG5, chondroitin sulfate proteoglycan 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NGC
  • Links
    NCBI Gene ID: 10675
    neXtProt AC: NX_O95196

  • Chr Location
    3p21.3; chr3:47562238-47580240 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased spontaneous postsynaptic currents, increased paired-pulse ratios, and reduced long term depression during early postnatal developmental stages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051478 VEGA Gene Model | MGI Sequence Detail 18794 C57BL/6J ±  kb
transcript OTTMUST00000130512 VEGA | MGI Sequence Detail 7868 Not Applicable  
polypeptide OTTMUSP00000069928 VEGA | MGI Sequence Detail 569 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    78 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005954 chondroitin sulfate proteoglycan 5
  • InterPro Domains
    IPR010555 Chondroitin sulphate attachment
    IPR000742 EGF-like domain
    IPR009505 Neural chondroitin sulphate proteoglycan cytoplasmic
Molecular
Reagents
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  • All nucleic 25
    cDNA 25

    Microarray probesets 4
Other
Accession IDs
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MGI:2143104
References
more
  • Summaries
    All 33
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:59346 Aono S, et al., Genomic organization and expression pattern of mouse neuroglycan C in the cerebellar development. J Biol Chem. 2000 Jan 7;275(1):337-42
  • Latest
    J:227884 Juttner R, et al., Impaired presynaptic function and elimination of synapses at premature stages during postnatal development of the cerebellum in the absence of CALEB (CSPG5/neuroglycan C). Eur J Neurosci. 2013 Nov;38(9):3270-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory