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Dtx1 Gene Detail
Summary
  • Symbol
    Dtx1
  • Name
    deltex 1, E3 ubiquitin ligase
  • Synonyms
    Fxit1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352744
    NCBI Gene: 14357
  • Gene Overview
    MyGene.info: DTX1
Location & Maps
more
  • Sequence Map
    Chr5:120680202-120711927 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      31726 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.64 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    DTX1, deltex E3 ubiquitin ligase 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DTX1, deltex E3 ubiquitin ligase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hDx-1
  • Links
    NCBI Gene ID: 1840
    neXtProt AC: NX_Q86Y01

  • Chr Location
    12q24.13; chr12:113056714-113098028 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 4 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Radiation induced
    1
  • Targeted
    8
  • Transgenic
    2
  • Genomic Mutations
    2 involving Dtx1
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Homozygous mutant mice are viable and fertile with normal B and T cell devlepment and function and no gross abnormalities in any of the major organs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    264
  • Tissues
    180
  • cDNA Data
    58
  • Literature Summary
    6
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025278 VEGA Gene Model | MGI Sequence Detail 31726 C57BL/6J ±  kb
transcript OTTMUST00000062218 VEGA | MGI Sequence Detail 4035 Not Applicable  
polypeptide OTTMUSP00000030640 VEGA | MGI Sequence Detail 627 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 68
    Genomic 7
    cDNA 58
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-36518, MGI:107938
References
more
  • Summaries
    All 48
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 18
  • Earliest
    J:35307 Pampeno CL, et al., A novel cDNA transcript expressed in fractionated X-irradiation-induced murine thymomas. Cell Growth Differ. 1996 Aug;7(8):1113-23
  • Latest
    J:221795 Hsiao HW, et al., Deltex1 antagonizes HIF-1alpha and sustains the stability of regulatory T cells in vivo. Nat Commun. 2015;6:6353
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory