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Dtx1 Gene Detail
Summary
  • Symbol
    Dtx1
  • Name
    deltex 1, E3 ubiquitin ligase
  • Synonyms
    Fxit1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352744
    NCBI Gene: 14357
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:120818267-120849992 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.64 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    988 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352744
 protein coding gene Chr5:120818267-120850879 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030012
 protein coding gene Chr5:124080882-124115787 (-)
A/J MGP_AJ_G0029976
 protein coding gene Chr5:118926710-118959572 (-)
AKR/J MGP_AKRJ_G0029915
 protein coding gene Chr5:122766842-122800308 (-)
BALB/cJ MGP_BALBcJ_G0029987
 protein coding gene Chr5:120345200-120376991 (-)
C3H/HeJ MGP_C3HHeJ_G0029707
 protein coding gene Chr5:123308210-123339971 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030442
 protein coding gene Chr5:128722859-128756510 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027668
 protein coding gene Chr5:113635100-113665411 (-)
CAST/EiJ MGP_CASTEiJ_G0029116
 protein coding gene Chr5:122433938-122466203 (-)
CBA/J MGP_CBAJ_G0029675
 protein coding gene Chr5:133728489-133774678 (-)
DBA/2J MGP_DBA2J_G0029825
 protein coding gene Chr5:119012099-119043643 (-)
FVB/NJ MGP_FVBNJ_G0029781
 protein coding gene Chr5:117943503-117977689 (-)
LP/J MGP_LPJ_G0029913
 protein coding gene Chr5:124530079-124561817 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029812
 protein coding gene Chr5:137683684-137716141 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030483
 protein coding gene Chr5:122347824-122379549 (-)
PWK/PhJ MGP_PWKPhJ_G0028829
 protein coding gene Chr5:117774965-117806975 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028668
 protein coding gene Chr5:120008674-120040430 (-)
WSB/EiJ MGP_WSBEiJ_G0029191
 protein coding gene Chr5:122938467-122967918 (-)



Homology
more
  • Human Ortholog
    DTX1, deltex E3 ubiquitin ligase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DTX1, deltex E3 ubiquitin ligase 1
  • Synonyms
    hDx-1, RNF140
  • Links
    NCBI Gene ID: 1840
    UniProt: Q86Y01

  • Chr Location
    12q24.13; chr12:113056730-113098028 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 6 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable and fertile with normal B and T cell devlepment and function and no gross abnormalities in any of the major organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    998
  • Tissues
    190
  • cDNA Data
    59
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029603 Ensembl Gene Model | MGI Sequence Detail 31726 C57BL/6J ±  kb
    transcript ENSMUST00000031607 Ensembl | MGI Sequence Detail 4035 Not Applicable  
    polypeptide ENSMUSP00000031607 Ensembl | MGI Sequence Detail 627 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 7
      cDNA 59
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36518, MGI:107938
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 10
      Gene Ontology 14
      Phenotypes 23
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory