About   Help   FAQ
Nkx6-2
Gene Detail
Symbol

Name
ID
Nkx6-2
NK6 homeobox 2
MGI:1352738
Synonyms
Gtx, Nkx6.2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
84.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:139579376-139582797 bp, - strand
From VEGA annotation of GRCm38

  3422 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18580  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nkx6-2

Human
homologs
Human Homolog NKX6-2, NK6 homeobox 2
NCBI Gene ID 84504
neXtProt AC  NX_Q9C056
Human Synonyms  GTX, NKX6.2, NKX6B
Human Chr (Location)  10q26; chr10:132784816-132786033 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Mice homozygous for a knock-out allele exhibit impaired coordination at 6 weeks of age and axon degeneration in the optic nerve at 7 months of age.
 
Interactions
Nkx6-2 interacts with 79 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (49 records)
Data Summary: Results (158)    Tissues (86)    Images (70)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 117
RT-PCR 36
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(8) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024503 (Evidence)
Ensembl Gene ModelENSMUSG00000041309 (Evidence)
Entrez Gene14912 (Evidence)
NIA Mouse Gene IndexU029411
Consensus CDS ProjectCCDS40170.1
International Mouse Knockout Project StatusNkx6-2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024503 VEGA Gene Model | MGI Sequence Detail 3422 C57BL/6J ±  kb
transcript OTTMUST00000060125 VEGA | MGI Sequence Detail 1907 Not Applicable 
polypeptide OTTMUSP00000029318 VEGA | MGI Sequence Detail 277 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(3) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000011251 homeobox protein Nkx-6.2
References
(Earliest) J:4385 Komuro I, et al., Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter. EMBO J. 1993 Apr;12(4):1387-401
(Latest) J:196218 Wang B, et al., Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants. J Comp Neurol. 2013 May 1;521(7):1561-84
All references(78)
Other
accession IDs
MGD-MRK-10330, MGI:95870

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory