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Nkx6-2
Gene Detail
Symbol

Name
ID
Nkx6-2
NK6 homeobox 2
MGI:1352738
Synonyms
Gtx, Nkx6.2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
84.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:139579376-139582797 bp, - strand
From VEGA annotation of GRCm38

  3422 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18580  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NKX6-2
Gene Tree: Nkx6-2

Human
homologs
NKX6-2, NK6 homeobox 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 84504
neXtProt AC: NX_Q9C056

Human Synonyms: GTX, NKX6.2, NKX6B

Human Chr (Location): 10q26; chr10:132784816-132786033 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Mice homozygous for a knock-out allele exhibit impaired coordination at 6 weeks of age and axon degeneration in the optic nerve at 7 months of age.
 
Interactions
Nkx6-2 interacts with 79 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (51 records)
Data Summary: Results (160)    Tissues (87)    Images (70)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 119
RT-PCR 36
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA NKX6-2 ; Xenbase nkx6-2 ; ZFIN nkx6.2    NEW 
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(8) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000024503 (Evidence)
Ensembl Gene Model ENSMUSG00000041309 (Evidence)
Entrez Gene 14912 (Evidence)
NIA Mouse Gene Index U029411
Consensus CDS Project CCDS40170.1
International Mouse Phenotyping Consortium Status Nkx6-2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024503 VEGA Gene Model | MGI Sequence Detail 3422 C57BL/6J ±  kb
transcript OTTMUST00000060125 VEGA | MGI Sequence Detail 1907 Not Applicable 
polypeptide OTTMUSP00000029318 VEGA | MGI Sequence Detail 277 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(3) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000011251 homeobox protein Nkx-6.2
References
(Earliest) J:4385 Komuro I, et al., Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter. EMBO J. 1993 Apr;12(4):1387-401
(Latest) J:220860 Magnani D, et al., The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon. Hum Mol Genet. 2015 May 1;24(9):2578-93
All references(80)
Other
accession IDs
MGD-MRK-10330, MGI:95870

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory