Nkx6-2 MGI Mouse Gene Detail - MGI:1352738

Symbol

Nkx6-2
Name

NK6 homeobox 2
Synonyms

Gtx, Nkx6.2

Feature Type

protein coding gene
IDs

MGI:1352738
NCBI Gene: 14912
Alliance

genome feature page
Transcription Start Sites

1 TSS
Regulated by

Rr169751 (1 regulatory region)

Sequence Map

Chr7:139159292-139162713 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 84.57 cM
Mapping Data

2 experiments

SNPs within 2kb

123 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352738	protein coding gene	Chr7:139159292-139162726 (-)
129S1/SvImJ	ENSMUSG00200041596	protein coding gene	Chr7:125721560-125724980 (-)
A/J	ENSMUSG00195033481	protein coding gene	Chr7:130198321-130201741 (-)
AKR/J	ENSMUSG00220026758	protein coding gene	Chr7:123681800-123685216 (-)
BALB/cJ	ENSMUSG00180037505	protein coding gene	Chr7:126896137-126899557 (-)
C3H/HeJ	ENSMUSG00175031409	protein coding gene	Chr7:127624438-127627858 (-)
C57BL/6NJ	ENSMUSG00215045518	protein coding gene	Chr7:126892755-126896176 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030618	protein coding gene	Chr7:141656551-141659989 (-)
CAST/EiJ	ENSTCUG00005050312	protein coding gene	Chr7:130179765-130183191 (-)
CBA/J	ENSMUSG00210026335	protein coding gene	Chr7:127357017-127360437 (-)
DBA/2J	ENSMUSG00185014455	protein coding gene	Chr7:131660777-131664197 (-)
FVB/NJ	ENSMUSG00205032416	protein coding gene	Chr7:127347661-127351081 (-)
JF1/MsJ	ENSUMUG00000040622	protein coding gene	Chr7:136744320-136747736 (-)
LP/J	ENSMUSG00230041766	protein coding gene	Chr7:137824586-137828006 (-)
NOD/ShiLtJ	ENSMUSG00190027664	protein coding gene	Chr7:127489947-127493367 (-)
NZO/HlLtJ	ENSMUSG00225050575	protein coding gene	Chr7:136035651-136039072 (-)
PWK/PhJ	ENSLUMG00010035683	protein coding gene	Chr7:125891352-125894768 (-)
SPRET/EiJ	ENSMSPG00010041695	protein coding gene	Chr7:127247939-127249871 (-)
WSB/EiJ	ENSIUOG00005029018	protein coding gene	Chr7:128177873-128181293 (-)

Human Ortholog

NKX6-2, NK6 homeobox 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NKX6-2, NK6 homeobox 2
Synonyms

GTX, NKX6.2, NKX6B, SPAX8
Links

HGNC:19321

NCBI Gene ID: 84504

UniProt: Q9C056
Chr Location

10q26.3; chr10:132783179-132786147 (-) GRCh38

MGI Vertebrate Homology

Nkx6-2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NKX6-2
Gene Tree

Nkx6-2

Diseases

1 with human NKX6-2 associations

				Human Disease	Mouse Models
				spastic ataxia 8 IDs spastic ataxia 8 DOID:0080252 OMIM:617560

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 4 alleles in 4 genetic backgrounds
7 phenotypes from multigenic genotypes
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

4
Radiation induced

1
Targeted

7
Genomic Mutations

1 involving Nkx6-2
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired coordination at 6 weeks of age and axon degeneration in the optic nerve at 7 months of age.

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All GO Annotations

34
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

878
Tissues

137
cDNA Data

9
Literature Summary

76

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NKX6-2

Xenbase nkx6-2

ZFIN nkx6-2

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All Sequences

40
RefSeq

7
UniProt

2
CCDS

CCDS40170.1

Ensembl

ENSMUSG00000041309 (Evidence)
NCBI Gene

14912

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041309	Ensembl Gene Model \| MGI Sequence Detail	3422	C57BL/6J	± kb
transcript	ENSMUST00000097974	Ensembl \| MGI Sequence Detail	1907	Not Applicable
polypeptide	ENSMUSP00000095588	Ensembl \| MGI Sequence Detail	277	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR000047 Helix-turn-helix motif

IPR017970 Homeobox, conserved site

IPR050394 Homeobox NK-like transcription regulators

IPR001356 Homeodomain

IPR009057 Homeodomain-like superfamily

IPR020479 Homeodomain, metazoa

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All nucleic 20

Genomic 2

cDNA 10

Primer pair 3

Other 5

Antibodies 4

Microarray probesets 4

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MGD-MRK-10330, MGI:95870

Summaries

All 127

Developmental Gene Expression 76

Gene Ontology 15

Phenotypes 31
Earliest

J:4385 Komuro I, et al., Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter. EMBO J. 1993 Apr;12(4):1387-401
Latest

J:370467 Gauberg J, et al., Spinal motor neuron development and metabolism are transcriptionally regulated by nuclear factor IA. Sci Adv. 2025 Aug;11(31):eadu3346

Nkx6-2 expression regulated by:

Feature	Feature Type	Location	Reference
Rr169751, regulatory region 169751	enhancer	Chr7:139107202-139111599	J:316612

TSS for Nkx6-2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75444	Chr7:139162708-139162724 (-)	-3 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24